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Gene Review

eat-5  -  Protein EAT-5

Caenorhabditis elegans

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High impact information on eat-5

  • Double mutants of mek-1 with an eat-5, eat-11 or eat-18 mutation, which are characterized by a limited feeding defect, showed distinct growth defects under normal conditions [1].
  • We show that a gene fusion of eat-5 to the green fluorescent protein is expressed in pharyngeal muscles. unc-7 and eat-5 are two of at least sixteen members of this family in C. elegans as determined by database searches and PCR-based screens [2].
  • We have isolated and characterized the C. elegans gene eat-5, which is required for synchronized pharyngeal muscle contractions, and find that it is a new member of this family [2].
  • Injection of carboxyfluorescein into muscles of the posterior pharynx demonstrates that all pharyngeal muscles are dye-coupled in wild-type animals; in eat-5 mutants, however, muscles of the anterior pharynx are no longer dye-coupled to posterior pharyngeal muscles [2].
  • In eat-5 mutants the motions of the different parts of the pharynx were poorly synchronized. eat-6 and eat-12 mutants failed to relax their pharyngeal muscles properly [3].

Biological context of eat-5


  1. A Caenorhabditis elegans MAP kinase kinase, MEK-1, is involved in stress responses. Koga, M., Zwaal, R., Guan, K.L., Avery, L., Ohshima, Y. EMBO J. (2000) [Pubmed]
  2. eat-5 and unc-7 represent a multigene family in Caenorhabditis elegans involved in cell-cell coupling. Starich, T.A., Lee, R.Y., Panzarella, C., Avery, L., Shaw, J.E. J. Cell Biol. (1996) [Pubmed]
  3. The genetics of feeding in Caenorhabditis elegans. Avery, L. Genetics (1993) [Pubmed]
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