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Gene Review

unc-7  -  Protein UNC-7

Caenorhabditis elegans

 
 
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High impact information on unc-7

  • We show that a gene fusion of eat-5 to the green fluorescent protein is expressed in pharyngeal muscles. unc-7 and eat-5 are two of at least sixteen members of this family in C. elegans as determined by database searches and PCR-based screens [1].
  • The sensitivity of these pathways is further modulated by unc-7, unc-9, and the Dyf (dye filling defective) genes, which alter the structure of the nervous system [2].
  • Two-factor crosses, deficiency mapping and three-factor crosses located pag-3 to the right arm of the X chromosome between unc-3 and unc-7 [3].
  • Mutations in the Caenorhabditis elegans gene unc-7 confer an uncoordinated phenotype [4].
  • We have physically mapped the region flanking the sites of Tc1 insertion and identified DNA rearrangements corresponding to eight additional unc-7 alleles [4].
 

Biological context of unc-7

 

Anatomical context of unc-7

  • We predict from our analysis of unc-7 genetic mosaics that the unc-7 gene product is not required in muscle cells for wild-type coordination but is probably required in motor neurons (although a hypodermal role has not been excluded) [4].

References

  1. eat-5 and unc-7 represent a multigene family in Caenorhabditis elegans involved in cell-cell coupling. Starich, T.A., Lee, R.Y., Panzarella, C., Avery, L., Shaw, J.E. J. Cell Biol. (1996) [Pubmed]
  2. The genetics of ivermectin resistance in Caenorhabditis elegans. Dent, J.A., Smith, M.M., Vassilatis, D.K., Avery, L. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. pag-3, a Caenorhabditis elegans gene involved in touch neuron gene expression and coordinated movement. Jia, Y., Xie, G., Aamodt, E. Genetics (1996) [Pubmed]
  4. Molecular and genetic analysis of unc-7, a Caenorhabditis elegans gene required for coordinated locomotion. Starich, T.A., Herman, R.K., Shaw, J.E. Genetics (1993) [Pubmed]
 
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