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Gene Review

DIO1  -  deiodinase, iodothyronine, type I

Homo sapiens

Synonyms: 5DI, DIOI, ITDI1, TXDI1, Type 1 DI, ...
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Disease relevance of DIO1


High impact information on DIO1

  • Consistent with these findings, reduction of SNF2H induces expression of an endogenous TR-regulated gene, dio1, in liver cells [2].
  • Likewise, the 5'-deiodinase (a thyroid basolateral membrane protein) encoded by the DIO1 gene was also distributed basolaterally in transfected MDCK cells [3].
  • A structural abnormality in the dio1 gene is not a likely explanation for this patient's D1-deficient phenotype [4].
  • Orchidectomy or estradiol treatment of ovariectomized females impacted stronger on renal than hepatic Dio1 expression [5].
  • In this study, we extend our analysis of the thyroid hormone response elements (TREs) in the 5' flanking region of the human dio1 gene [6].

Biological context of DIO1

  • Gene expression profiles reveal that DCN, DIO1, and DIO2 are underexpressed in benign and malignant thyroid tumors [1].
  • However, the retinoic acid response of the 716-bp dio1 5' flanking region is unaffected by elimination of TRE2 but is lost with mutations in TRE1 [6].
  • An SP1 binding site immediately 5' to TRE2 increases basal expression of a 430-bp dio1 promoter-chloramphenicol acetyltransferase construct in the presence of unliganded thyroid hormone receptor, thus decreasing T3 responsiveness, but does not do so when this complex is placed in its more 5' wild-type location [6].

Associations of DIO1 with chemical compounds


Analytical, diagnostic and therapeutic context of DIO1

  • This study prospectively compared the efficacy of single intravenous infusion of total dose iron (ITDI group) given in an outpatient setting with oral iron (oral group) for the treatment of anemia in PD patients [8].


  1. Gene expression profiles reveal that DCN, DIO1, and DIO2 are underexpressed in benign and malignant thyroid tumors. Arnaldi, L.A., Borra, R.C., Maciel, R.M., Cerutti, J.M. Thyroid (2005) [Pubmed]
  2. The N-CoR complex enables chromatin remodeler SNF2H to enhance repression by thyroid hormone receptor. Alenghat, T., Yu, J., Lazar, M.A. EMBO J. (2006) [Pubmed]
  3. Polarized targeting of epithelial cell proteins in thyrocytes and MDCK cells. Prabakaran, D., Ahima, R.S., Harney, J.W., Berry, M.J., Larsen, P.R., Arvan, P. J. Cell. Sci. (1999) [Pubmed]
  4. The structure of the coding and 5'-flanking region of the type 1 iodothyronine deiodinase (dio1) gene is normal in a patient with suspected congenital dio1 deficiency. Toyoda, N., Kleinhaus, N., Larsen, P.R. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  5. Selenium-dependent pre- and posttranscriptional mechanisms are responsible for sexual dimorphic expression of selenoproteins in murine tissues. Riese, C., Michaelis, M., Mentrup, B., G??tz, F., K??hrle, J., Schweizer, U., Schomburg, L. Endocrinology (2006) [Pubmed]
  6. Further characterization of thyroid hormone response elements in the human type 1 iodothyronine deiodinase gene. Zhang, C.Y., Kim, S., Harney, J.W., Larsen, P.R. Endocrinology (1998) [Pubmed]
  7. Differential control of type-I iodothyronine deiodinase expression by the activation of the cyclic AMP and phosphoinositol signalling pathways in cultured human thyrocytes. Beech, S.G., Walker, S.W., Arthur, J.R., Lee, D., Beckett, G.J. J. Mol. Endocrinol. (1995) [Pubmed]
  8. Intravenous infusion of total dose iron is superior to oral iron in treatment of anemia in peritoneal dialysis patients: a single center comparative study. Ahsan, N. J. Am. Soc. Nephrol. (1998) [Pubmed]
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