Gene Review:
DCN - decorin
Homo sapiens
Synonyms:
Bone proteoglycan II, CSCD, DSPG2, Decorin, PG-S2, ...
Gonzalez-Cadavid,
Rajfer,
Yoshida,
Suzuki,
Honda,
Amemiya,
Nakatani,
Ebina,
Narumi,
Satoh,
Munakata,
Stokes,
Hudkins,
Zaharia,
Taneda,
Alpers,
Schaefer,
Gröne,
Raslik,
Robenek,
Ugorcakova,
Budny,
Schaefer,
Kresse,
Yamamoto,
Eckes,
Krieg,
Seo,
Hocking,
Höök,
McQuillan,
von Kaisenberg,
Prols,
Nicolaides,
Maass,
Meinhold-Heerlein,
Brand-Saberi,
Merle,
Malaval,
Lawler,
Delmas,
Clezardin,
Schönherr,
Broszat,
Brandan,
Bruckner,
Kresse,
- Decorin, versican, and biglycan gene expression by keloid and normal dermal fibroblasts: differential regulation by basic fibroblast growth factor. Tan, E.M., Hoffren, J., Rouda, S., Greenbaum, S., Fox, J.W., Moore, J.H., Dodge, G.R. Exp. Cell Res. (1993)
- Expression of decorin, biglycan, and collagen type I in human renal fibrosing disease. Stokes, M.B., Holler, S., Cui, Y., Hudkins, K.L., Eitner, F., Fogo, A., Alpers, C.E. Kidney Int. (2000)
- Small proteoglycans of normal adult human kidney: distinct expression patterns of decorin, biglycan, fibromodulin, and lumican. Schaefer, L., Gröne, H.J., Raslik, I., Robenek, H., Ugorcakova, J., Budny, S., Schaefer, R.M., Kresse, H. Kidney Int. (2000)
- Delayed appearance of decorin in healing burn scars. Sayani, K., Dodd, C.M., Nedelec, B., Shen, Y.J., Ghahary, A., Tredget, E.E., Scott, P.G. Histopathology (2000)
- Peripheral distribution of dermatan sulfate proteoglycans (decorin) in amyloid-containing plaques and their presence in neurofibrillary tangles of Alzheimer's disease. Snow, A.D., Mar, H., Nochlin, D., Kresse, H., Wight, T.N. J. Histochem. Cytochem. (1992)
- Mechanisms of Disease: new insights into the cellular and molecular pathology of Peyronie's disease. Gonzalez-Cadavid, N.F., Rajfer, J. Nature clinical practice. Urology. (2005)
- Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. Border, W.A., Noble, N.A., Yamamoto, T., Harper, J.R., Yamaguchi, Y., Pierschbacher, M.D., Ruoslahti, E. Nature (1992)
- Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Yamaguchi, Y., Mann, D.M., Ruoslahti, E. Nature (1990)
- Expression of human proteoglycan in Chinese hamster ovary cells inhibits cell proliferation. Yamaguchi, Y., Ruoslahti, E. Nature (1988)
- Localization of a binding site for the proteoglycan decorin on collagen XIV (undulin). Ehnis, T., Dieterich, W., Bauer, M., Kresse, H., Schuppan, D. J. Biol. Chem. (1997)
- Decorin core protein secretion is regulated by N-linked oligosaccharide and glycosaminoglycan additions. Seo, N.S., Hocking, A.M., Höök, M., McQuillan, D.J. J. Biol. Chem. (2005)
- Decorin gene transfer-mediated suppression of TGF-beta synthesis abrogates experimental malignant glioma growth in vivo. Ständer, M., Naumann, U., Dumitrescu, L., Heneka, M., Löschmann, P., Gulbins, E., Dichgans, J., Weller, M. Gene Ther. (1998)
- Fibroblasts from post-burn hypertrophic scar tissue synthesize less decorin than normal dermal fibroblasts. Scott, P.G., Dodd, C.M., Ghahary, A., Shen, Y.J., Tredget, E.E. Clin. Sci. (1998)
- Central role of TGF-beta in the pathogenesis of diabetic nephropathy and macrovascular complications: a hypothesis. Yokoyama, H., Deckert, T. Diabet. Med. (1996)
- Localization of PGI (biglycan, BGN) and PGII (decorin, DCN, PG-40) genes on human chromosomes Xq13-qter and 12q, respectively. McBride, O.W., Fisher, L.W., Young, M.F. Genomics (1990)
- Decorin inhibits cell attachment to thrombospondin-1 by binding to a KKTR-dependent cell adhesive site present within the N-terminal domain of thrombospondin-1. Merle, B., Malaval, L., Lawler, J., Delmas, P., Clezardin, P. J. Cell. Biochem. (1997)
- Decorin activates the epidermal growth factor receptor and elevates cytosolic Ca2+ in A431 carcinoma cells. Patel, S., Santra, M., McQuillan, D.J., Iozzo, R.V., Thomas, A.P. J. Biol. Chem. (1998)
- Glycosaminoglycans and proteoglycans in the skin of aneuploid fetuses with increased nuchal translucency. von Kaisenberg, C.S., Prols, F., Nicolaides, K.H., Maass, N., Meinhold-Heerlein, I., Brand-Saberi, B. Hum. Reprod. (2003)
- Interleukin (IL)-6 and IL-10 induce decorin mRNA in endothelial cells, but interaction with fibrillar collagen is essential for its translation. Strazynski, M., Eble, J.A., Kresse, H., Schönherr, E. J. Biol. Chem. (2004)
- Interaction of heparin cofactor II with biglycan and decorin. Whinna, H.C., Choi, H.U., Rosenberg, L.C., Church, F.C. J. Biol. Chem. (1993)
- Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-beta1 release. Imai, K., Hiramatsu, A., Fukushima, D., Pierschbacher, M.D., Okada, Y. Biochem. J. (1997)
- The effect of glucocorticoid on the synthesis of biglycan and decorin in human osteoblasts and bone marrow stromal cells. Kimoto, S., Cheng, S.L., Zhang, S.F., Avioli, L.V. Endocrinology (1994)
- Decorin core protein fragment Leu155-Val260 interacts with TGF-beta but does not compete for decorin binding to type I collagen. Schönherr, E., Broszat, M., Brandan, E., Bruckner, P., Kresse, H. Arch. Biochem. Biophys. (1998)
- Leucine-rich repeat region of decorin binds to filamin-A. Yoshida, K., Suzuki, Y., Honda, E., Amemiya, K., Nakatani, T., Ebina, M., Narumi, K., Satoh, K., Munakata, H. Biochimie (2002)
- Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis. Zhu, J.X., Goldoni, S., Bix, G., Owens, R.T., McQuillan, D.J., Reed, C.C., Iozzo, R.V. J. Biol. Chem. (2005)
- Effects of rhDecorin on TGF-beta1 induced human hepatic stellate cells LX-2 activation. Shi, Y.F., Zhang, Q., Cheung, P.Y., Shi, L., Fong, C.C., Zhang, Y., Tzang, C.H., Chan, B.P., Fong, W.F., Chun, J., Kung, H.F., Yang, M. Biochim. Biophys. Acta (2006)
- Isolation and characterization of fibroblasts derived from regenerating human periodontal defects. Ivanovski, S., Haase, H.R., Bartold, P.M. Arch. Oral Biol. (2001)
- Effect of interleukin-10 on the gene expression of type I collagen, fibronectin, and decorin in human skin fibroblasts: differential regulation by transforming growth factor-beta and monocyte chemoattractant protein-1. Yamamoto, T., Eckes, B., Krieg, T. Biochem. Biophys. Res. Commun. (2001)
- Beta ig-h3 interacts directly with biglycan and decorin, promotes collagen VI aggregation, and participates in ternary complexing with these macromolecules. Reinboth, B., Thomas, J., Hanssen, E., Gibson, M.A. J. Biol. Chem. (2006)
- Extracellular matrix stoichiometry in osteoblasts from patients with osteogenesis imperfecta. Fedarko, N.S., Robey, P.G., Vetter, U.K. J. Bone Miner. Res. (1995)
- Up-regulation of extracellular matrix proteoglycans and collagen type I in human crescentic glomerulonephritis. Stokes, M.B., Hudkins, K.L., Zaharia, V., Taneda, S., Alpers, C.E. Kidney Int. (2001)
- Differential regulation of extracellular matrix proteoglycan (PG) gene expression. Transforming growth factor-beta 1 up-regulates biglycan (PGI), and versican (large fibroblast PG) but down-regulates decorin (PGII) mRNA levels in human fibroblasts in culture. Kähäri, V.M., Larjava, H., Uitto, J. J. Biol. Chem. (1991)
- Expression of extracellular matrix molecules in human mesangial cells in response to prolonged hyperglycaemia. Wahab, N.A., Harper, K., Mason, R.M. Biochem. J. (1996)