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Gene Review

ina-1  -  Protein INA-1

Caenorhabditis elegans

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Disease relevance of ina-1


High impact information on ina-1

  • Our analysis of C. elegans ina-1 alpha integrin mutants provides the first genetic evidence that migrating neurons require integrins [1].
  • In addition to these neuronal phenotypes, ina-1 mutants also display many morphogenetic defects [1].
  • At least nine protein bands with relative molecular weights in the range observed for known integrin alpha subunits coprecipitate with beta pat-3, and at least three of these bands migrate in SDS-PAGE with increased mobility when reduced [2].
  • A significant aggravation of this defect is observed when mig-15 activity is compromised in a weak ina-1 background [3].
  • Integrins are expressed by all multicellular animals, but their diversity varies widely among species; for example, in mammals, 19 alpha and 8 beta subunit genes encode polypeptides that combine to form 25 different receptors, whereas the Drosophila and Caenorhabditis genomes encode only five and two integrin alpha subunits respectively [4].


  1. Neuronal migrations and axon fasciculation are disrupted in ina-1 integrin mutants. Baum, P.D., Garriga, G. Neuron (1997) [Pubmed]
  2. Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans. Gettner, S.N., Kenyon, C., Reichardt, L.F. J. Cell Biol. (1995) [Pubmed]
  3. A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans. Poinat, P., De Arcangelis, A., Sookhareea, S., Zhu, X., Hedgecock, E.M., Labouesse, M., Georges-Labouesse, E. Curr. Biol. (2002) [Pubmed]
  4. Integrin structure. Humphries, M.J. Biochem. Soc. Trans. (2000) [Pubmed]
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