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Gene Review

Itga6  -  integrin alpha 6

Mus musculus

Synonyms: 5033401O05Rik, AI115430, CD49 antigen-like family member F, Cd49f, Integrin alpha-6, ...
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Disease relevance of Itga6


High impact information on Itga6


Chemical compound and disease context of Itga6


Biological context of Itga6


Anatomical context of Itga6


Associations of Itga6 with chemical compounds

  • Another possibility is that the antibodies against integrin alpha 6 and beta 1 subunit cause abnormal signalling by the integrin [19].
  • Binding to laminin (or fragment E8), but not to kalinin was partially blocked by a monoclonal antibody specific for the integrin alpha 6 subunit, and only in the initial phase of adhesion [20].
  • Antibodies against the E8 domain of laminin and antibodies against the alpha 6 and beta 1 chains of platelet membrane glycoprotein very late activation antigen-6 (VLA-6), completely inhibited adhesion [21].
  • Calphostin C, a protein kinase C (PKC) inhibitor, markedly inhibited the enhancement of IFN-gamma mRNA expression in a dose-dependent manner, which suggested that PKC acted as a second messenger in the IFN-gamma mRNA expression mediated by the interaction of VLA-6 with LN in CTLL-2 cells [22].
  • Furthermore, the anti-alpha 6 mAb OG-1, which does not inhibit the interaction between integrin alpha 6 beta 1 and LN, had no effect on the progesterone production by GC cultured on LN [23].

Other interactions of Itga6


Analytical, diagnostic and therapeutic context of Itga6


  1. Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. Georges-Labouesse, E., Messaddeq, N., Yehia, G., Cadalbert, L., Dierich, A., Le Meur, M. Nat. Genet. (1996) [Pubmed]
  2. A splice variant of alpha 6 integrin is associated with malignant conversion in mouse skin tumorigenesis. Tennenbaum, T., Belanger, A.J., Glick, A.B., Tamura, R., Quaranta, V., Yuspa, S.H. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. Abnormal expression of integrin alpha 6 beta 4 in cervical intraepithelial neoplasia. Aplin, J.D., Dawson, S., Seif, M.W. Br. J. Cancer (1996) [Pubmed]
  4. Adhesion molecules in intestinal Schistosoma mansoni infection. Jacobs, W., Bogers, J.J., Timmermans, J.P., Deelder, A.M., Van Marck, E.A. Parasitol. Res. (1998) [Pubmed]
  5. An epitope on VLA-6 (alpha6beta1) integrin involved in migration but not adhesion is required for extravasation of murine melanoma B16F1 cells in liver. Hangan, D., Morris, V.L., Boeters, L., von Ballestrem, C., Uniyal, S., Chan, B.M. Cancer Res. (1997) [Pubmed]
  6. Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice. van der Neut, R., Krimpenfort, P., Calafat, J., Niessen, C.M., Sonnenberg, A. Nat. Genet. (1996) [Pubmed]
  7. Laminin receptor on platelets is the integrin VLA-6. Sonnenberg, A., Modderman, P.W., Hogervorst, F. Nature (1988) [Pubmed]
  8. Triggering through CD16 or phorbol esters enhances adhesion of NK cells to laminin via very late antigen 6. Gismondi, A., Mainiero, F., Morrone, S., Palmieri, G., Piccoli, M., Frati, L., Santoni, A. J. Exp. Med. (1992) [Pubmed]
  9. Antibodies against domain E3 of laminin-1 and integrin alpha 6 subunit perturb branching epithelial morphogenesis of submandibular gland, but by different modes. Kadoya, Y., Kadoya, K., Durbeej, M., Holmvall, K., Sorokin, L., Ekblom, P. J. Cell Biol. (1995) [Pubmed]
  10. Variants of the alpha 6 beta 1 laminin receptor in early murine development: distribution, molecular cloning and chromosomal localization of the mouse integrin alpha 6 subunit. Hierck, B.P., Thorsteinsdóttir, S., Niessen, C.M., Freund, E., Iperen, L.V., Feyen, A., Hogervorst, F., Poelmann, R.E., Mummery, C.L., Sonnenberg, A. Cell Adhes. Commun. (1993) [Pubmed]
  11. Integrin alpha 6A beta 1 induces CD81-dependent cell motility without engaging the extracellular matrix migration substrate. Domanico, S.Z., Pelletier, A.J., Havran, W.L., Quaranta, V. Mol. Biol. Cell (1997) [Pubmed]
  12. The alpha 6 beta 1 (VLA-6) and alpha 6 beta 4 protein complexes: tissue distribution and biochemical properties. Sonnenberg, A., Linders, C.J., Daams, J.H., Kennel, S.J. J. Cell. Sci. (1990) [Pubmed]
  13. Monoclonal antibodies to the murine VLA-6 alpha-chain trigger homotypic lymphocyte aggregation. Wuthrich, R.P. Immunology (1992) [Pubmed]
  14. Integrin VLA-6 (alpha 6 beta 1) mediates adhesion of mouse bone marrow-derived mast cells to laminin. Fehlner-Gardiner, C., Uniyal, S., von Ballestrem, C., Dougherty, G.J., Chan, B.M. Allergy (1996) [Pubmed]
  15. Integrin alpha 6 beta 4 forms a complex with the cytoskeletal protein HD1 and induces its redistribution in transfected COS-7 cells. Niessen, C.M., Hulsman, E.H., Rots, E.S., Sánchez-Aparicio, P., Sonnenberg, A. Mol. Biol. Cell (1997) [Pubmed]
  16. CD9 controls the formation of clusters that contain tetraspanins and the integrin alpha 6 beta 1, which are involved in human and mouse gamete fusion. Ziyyat, A., Rubinstein, E., Monier-Gavelle, F., Barraud, V., Kulski, O., Prenant, M., Boucheix, C., Bomsel, M., Wolf, J.P. J. Cell. Sci. (2006) [Pubmed]
  17. Identification and functional characterization of mouse CD29 with a mAb. Noto, K., Kato, K., Okumura, K., Yagita, H. Int. Immunol. (1995) [Pubmed]
  18. Integrin alpha 6 expression is required for early nervous system development in Xenopus laevis. Lallier, T.E., Whittaker, C.A., DeSimone, D.W. Development (1996) [Pubmed]
  19. Integrin alpha 6B beta 1 is involved in kidney tubulogenesis in vitro. Falk, M., Salmivirta, K., Durbeej, M., Larsson, E., Ekblom, M., Vestweber, D., Ekblom, P. J. Cell. Sci. (1996) [Pubmed]
  20. Formation of hemidesmosomes in cells of a transformed murine mammary tumor cell line and mechanisms involved in adherence of these cells to laminin and kalinin. Sonnenberg, A., de Melker, A.A., Martinez de Velasco, A.M., Janssen, H., Calafat, J., Niessen, C.M. J. Cell. Sci. (1993) [Pubmed]
  21. Platelet adhesion to laminin: role of Ca2+ and Mg2+ ions, shear rate, and platelet membrane glycoproteins. Hindriks, G., Ijsseldijk, M.J., Sonnenberg, A., Sixma, J.J., de Groot, P.G. Blood (1992) [Pubmed]
  22. Protein kinase C mediates the signal for interferon-gamma mRNA expression in cytotoxic T cells after their adhesion to laminin. Li, Y.Q., Kobayashi, M., Yuan, L., Wang, J., Matsushita, K., Hamada, J.I., Kimura, K., Yagita, H., Okumura, K., Hosokawa, M. Immunology (1998) [Pubmed]
  23. Laminin suppresses progesterone production by human luteinizing granulosa cells via interaction with integrin alpha 6 beta 1. Fujiwara, H., Honda, T., Ueda, M., Nakamura, K., Yamada, S., Maeda, M., Mori, T. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  24. Impaired migration of NOD mouse thymocytes: a fibronectin receptor-related defect. Cotta-de-Almeida, V., Villa-Verde, D.M., Lepault, F., Pléau, J.M., Dardenne, M., Savino, W. Eur. J. Immunol. (2004) [Pubmed]
  25. Interaction of merosin (laminin 2) with very late activation antigen-6 is necessary for the survival of CD4+ CD8+ immature thymocytes. Iwao, M., Fukada, S., Harada, T., Tsujikawa, K., Yagita, H., Hiramine, C., Miyagoe, Y., Takeda, S., Yamamoto, H. Immunology (2000) [Pubmed]
  26. Recognition of the laminin E8 cell-binding site by an integrin possessing the alpha 6 subunit is essential for epithelial polarization in developing kidney tubules. Sorokin, L., Sonnenberg, A., Aumailley, M., Timpl, R., Ekblom, P. J. Cell Biol. (1990) [Pubmed]
  27. Characterization of a liver metastatic variant of murine K1735M2 melanoma cells. Ikeda, T., Murakami, K., Sakukaw, R., Hayakawa, Y., Saiki, I. In Vivo (2000) [Pubmed]
  28. Analysis of integrin receptors for laminin and type IV collagen on metastatic B16 melanoma cells. Ramos, D.M., Berston, E.D., Kramer, R.H. Cancer Res. (1990) [Pubmed]
  29. Integrin alpha 6 is a differentiation antigen of human granulosa cells. Honda, T., Fujiwara, H., Ueda, M., Maeda, M., Mori, T. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  30. Defects of basement membrane and hemidesmosome structure correlate with malignant phenotype and stromal interactions in HaCaT-Ras xenografts. Tomakidi, P., Mirancea, N., Fusenig, N.E., Herold-Mende, C., Bosch, F.X., Breitkreutz, D. Differentiation (1999) [Pubmed]
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