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Gene Review

spe-26  -  Protein SPE-26

Caenorhabditis elegans

 
 
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Disease relevance of spe-26

 

High impact information on spe-26

  • The functional importance of these repeat motifs is shown by the fact that five of the spe-26 mutations are in the tandem repeats, and one of the most severe mutations is a substitution in a highly conserved glycine [1].
  • The spe-26 gene is expressed throughout the testis in both spermatogonial cells and spermatocytes [1].
  • These results suggest that spe-26 encodes a cytoskeletal protein, perhaps actin binding, which is necessary to segregate the cellular components that form haploid spermatids [1].
  • Long-lived spe-26 and daf-2 mutants also exhibit Itt [2].
  • The mutations in daf-16 did not alter the reduced fertility of spe-26 and interestingly a daf-16 mutant is more fertile than wild type [3].
 

Biological context of spe-26

  • In contrast, a spe-26 mutant had a tenfold lower mortality until approximately 2 weeks of age but ultimately achieved a higher mortality, whereas clk-1 mutants show slightly higher mortality than wild type during the fertile period, early in life, but ultimately level off at lower mortality [4].

References

  1. The Caenorhabditis elegans spe-26 gene is necessary to form spermatids and encodes a protein similar to the actin-associated proteins kelch and scruin. Varkey, J.P., Muhlrad, P.J., Minniti, A.N., Do, B., Ward, S. Genes Dev. (1995) [Pubmed]
  2. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Lithgow, G.J., White, T.M., Melov, S., Johnson, T.E. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Murakami, S., Johnson, T.E. Genetics (1996) [Pubmed]
  4. Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects. Johnson, T.E., Wu, D., Tedesco, P., Dames, S., Vaupel, J.W. J. Gerontol. A Biol. Sci. Med. Sci. (2001) [Pubmed]
 
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