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Gene Review

CADPS  -  Ca++-dependent secretion activator

Homo sapiens

Synonyms: CADPS1, CAPS, CAPS-1, CAPS1, Calcium-dependent activator protein for secretion 1, ...
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Disease relevance of CADPS

  • The small patchy hyperintense white matter lesions represented myelin pallor associated with vessels showing hypertension and arteriosclerotic changes. 'Caps' also showed myelin pallor with dilated perivascular spaces [1].
  • Homologues to CspA, the major cold-shock protein in E. coli, have been described in various psychrotrophs, but unlike their mesophilic counterparts, they belong to the group of Caps [2].

Psychiatry related information on CADPS

  • Subjects met DSM-III-R criteria for PTSD and criteria for PTSD on the Clinician-Administered PTSD Scale, 1-month version (CAPS-1) [3].

High impact information on CADPS

  • In contrast to CAPS1, which is expressed almost exclusively in brain and neuroendocrine tissues, CAPS2 is also expressed in lung, liver, and testis [4].
  • The primary outcome measures were changes in score from baseline on the CAPS-1 and the Clinician-Administered PTSD Scale, 1-week version (CAPS-2) [3].
  • We also began the effort of differentiating true associated SNPs by selecting a small subset of significant SNPs (N = 26) and genotyped these in an independent sample of approximately 1,900 CAPS1 subjects [5].
  • Deletion mapping localized the D2 receptor binding site to a segment located within the C-terminal region of CAPS1 as well CAPS2 [6].
  • CAPS1 is an evolutionarily conserved calcium binding protein essential for late-stage exocytosis of neurotransmitters from synaptic terminals [6].

Biological context of CADPS

  • We propose that CADPS functions as a calcium sensor in regulated exocytosis, whereas CADPS2 acts as a calcium sensor in constitutive vesicle trafficking and secretion [7].
  • CADPS and CADPS2 were determined to span 475 kb and 561 kb on human chromosomes 3p21.1 and 7q31.3, respectively [7].
  • We also identify a C2 domain, a known protein motif involved in calcium and phospholipid interactions, in both CADPS and CADPS2 [7].
  • These last proteins were also overexpressed in cells growing at 4 degrees C and were considered to be early cold acclimation proteins (Caps) [8].

Anatomical context of CADPS


Associations of CADPS with chemical compounds

  • CAPS1 interaction was confirmed for both the long and short isoforms of the D2 receptor, but not with any other dopamine receptor subtype [6].
  • Linear standard curves were obtained for 1 to 10 micrograms of bovine serum albumin measured in the presence of 50 mM Mes, Mops, Pipes, Caps, Bes, Hepes, Heppso, and Tes zwitterionic buffers using bicinchoninic acid for detection [9].
  • Period analysis revealed that a 300-mg dose of papaverine (Pavabid Plateau Caps) increased EEG alpha activity (8-13 cycles per second) and decreased the beta2 range (27-40 cps) [10].
  • Carotenogenic capacity of the cultivars has been discussed relative to total carotenoid content and the R/Y and Caps/Zeax ratios, the main quality traits for breeding cultivars for production of high-quality paprika [11].

Physical interactions of CADPS

  • We identified CAPS1 (calcium-dependent activator protein for secretion) as a D2 dopamine receptor interacting protein (DRIP) in a yeast two-hybrid screen of a human brain library using the second intracellular domain of the human D2 receptor (D2IC2) [6].

Other interactions of CADPS

  • Interaction between CAPS1 and the D2 receptor was validated using both pulldown and coimmunoprecipitation assays [6].

Analytical, diagnostic and therapeutic context of CADPS

  • Each cavity was filled with one of the four provisional materials selected for the evaluation (Cavit-W, IRM Caps, Guttapercha, Fermit-N), and the interim prostheses were delivered to the patients [12].


  1. Pathologic findings of silent hyperintense white matter lesions on MRI. Takao, M., Koto, A., Tanahashi, N., Fukuuchi, Y., Takagi, M., Morinaga, S. J. Neurol. Sci. (1999) [Pubmed]
  2. Cold shock response and low temperature adaptation in psychrotrophic bacteria. Hébraud, M., Potier, P. J. Mol. Microbiol. Biotechnol. (1999) [Pubmed]
  3. A preliminary study of risperidone in the treatment of posttraumatic stress disorder related to childhood abuse in women. Reich, D.B., Winternitz, S., Hennen, J., Watts, T., Stanculescu, C. The Journal of clinical psychiatry. (2004) [Pubmed]
  4. A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. Speidel, D., Varoqueaux, F., Enk, C., Nojiri, M., Grishanin, R.N., Martin, T.F., Hofmann, K., Brose, N., Reim, K. J. Biol. Chem. (2003) [Pubmed]
  5. A comprehensive association study for genes in inflammation pathway provides support for their roles in prostate cancer risk in the CAPS study. Zheng, S.L., Liu, W., Wiklund, F., Dimitrov, L., Bälter, K., Sun, J., Adami, H.O., Johansson, J.E., Sun, J., Chang, B., Loza, M., Turner, A.R., Bleecker, E.R., Meyers, D.A., Carpten, J.D., Duggan, D., Isaacs, W.B., Xu, J., Grönberg, H. Prostate (2006) [Pubmed]
  6. Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS). Binda, A.V., Kabbani, N., Levenson, R. Biochem. Pharmacol. (2005) [Pubmed]
  7. Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family. Cisternas, F.A., Vincent, J.B., Scherer, S.W., Ray, P.N. Genomics (2003) [Pubmed]
  8. Cold shock and cold acclimation proteins in the psychrotrophic bacterium Arthrobacter globiformis SI55. Berger, F., Morellet, N., Menu, F., Potier, P. J. Bacteriol. (1996) [Pubmed]
  9. Effect of zwitterionic buffers on measurement of small masses of protein with bicinchoninic acid. Kaushal, V., Barnes, L.D. Anal. Biochem. (1986) [Pubmed]
  10. Electroencephalographic and behavioral changes associated with papaverine administration in healthy geriatric subjects. Cole, J.O., Branconnier, R.J., Martin, G.F. Journal of the American Geriatrics Society. (1975) [Pubmed]
  11. Characterization of carotenoid high-producing Capsicum annuum cultivars selected for paprika production. Hornero-Méndez, D., Costa-García, J., Mínguez-Mosquera, M.I. J. Agric. Food Chem. (2002) [Pubmed]
  12. Microleakage of temporary endodontic restorations in overdenture tooth abutments. Scotti, R., Ciocca, L., Baldissara, P. The International journal of prosthodontics. (2002) [Pubmed]
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