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MeSH Review

Sindbis Virus

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Disease relevance of Sindbis Virus


High impact information on Sindbis Virus


Chemical compound and disease context of Sindbis Virus


Biological context of Sindbis Virus


Anatomical context of Sindbis Virus


Gene context of Sindbis Virus

  • When Sindbis virus is used, these cells show high susceptibility to human IFN-gamma [25].
  • Some of these adaptive mutations (e.g., in hepatitis C virus) increase the ability of RNA replication to resist the antiviral action of alpha/beta interferon (IFN-alpha/beta); others (e.g., in Sindbis virus) may also lead to more efficient IFN production [26].
  • ISG15 expression protected against Sindbis virus-induced lethality and decreased Sindbis virus replication in multiple organs without inhibiting the spread of virus throughout the host [27].
  • Differential regulation of Bcl-2 and Bax expression in cells infected with virulent and nonvirulent strains of sindbis virus [28].
  • The brains of mice infected with SIN/beclin had fewer Sindbis virus RNA-positive cells, fewer apoptotic cells, and lower viral titers than the brains of mice infected with SIN/beclinDeltaBcl-2BD or SIN/beclinstop [29].

Analytical, diagnostic and therapeutic context of Sindbis Virus


  1. Structure of Sindbis virus core protein reveals a chymotrypsin-like serine proteinase and the organization of the virion. Choi, H.K., Tong, L., Minor, W., Dumas, P., Boege, U., Rossmann, M.G., Wengler, G. Nature (1991) [Pubmed]
  2. Molecular strategies for interrupting arthropod-borne virus transmission by mosquitoes. Blair, C.D., Adelman, Z.N., Olson, K.E. Clin. Microbiol. Rev. (2000) [Pubmed]
  3. Glutamate receptor antagonists protect from virus-induced neural degeneration. Nargi-Aizenman, J.L., Havert, M.B., Zhang, M., Irani, D.N., Rothstein, J.D., Griffin, D.E. Ann. Neurol. (2004) [Pubmed]
  4. Effects of chloroquine and cytochalasin B on the infection of cells by Sindbis virus and vesicular stomatitis virus. Coombs, K., Mann, E., Edwards, J., Brown, D.T. J. Virol. (1981) [Pubmed]
  5. A single deletion in the membrane-proximal region of the Sindbis virus glycoprotein E2 endodomain blocks virus assembly. Hernandez, R., Lee, H., Nelson, C., Brown, D.T. J. Virol. (2000) [Pubmed]
  6. Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection. Ritchie, K.J., Hahn, C.S., Kim, K.I., Yan, M., Rosario, D., Li, L., de la Torre, J.C., Zhang, D.E. Nat. Med. (2004) [Pubmed]
  7. Di-and trimethylated congeners of 7-methylguanine in Sindbis virus mRNA. HsuChen, C.C., Dubin, D.T. Nature (1976) [Pubmed]
  8. A Salmonella virulence protein that inhibits cellular trafficking. Uchiya, K., Barbieri, M.A., Funato, K., Shah, A.H., Stahl, P.D., Groisman, E.A. EMBO J. (1999) [Pubmed]
  9. Use of Sindbis virus-mediated RNA interference to demonstrate a conserved role of Broad-Complex in insect metamorphosis. Uhlirova, M., Foy, B.D., Beaty, B.J., Olson, K.E., Riddiford, L.M., Jindra, M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  10. Epstein-Barr virus EBNA2 blocks Nur77- mediated apoptosis. Lee, J.M., Lee, K.H., Weidner, M., Osborne, B.A., Hayward, S.D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  11. Neurovirulent strains of Alphavirus induce apoptosis in bcl-2-expressing cells: role of a single amino acid change in the E2 glycoprotein. Ubol, S., Tucker, P.C., Griffin, D.E., Hardwick, J.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  12. Natural immunity to Sindbis virus is influenced by host tissue sialic acid content. Hirsch, R.L., Griffin, D.E., Winkelstein, J.A. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  13. Engineered defective interfering RNAs of Sindbis virus express bacterial chloramphenicol acetyltransferase in avian cells. Levis, R., Huang, H., Schlesinger, S. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  14. Evidence for covalent attachment of fatty acids to Sindbis virus glycoproteins. Schmidt, M.F., Bracha, M., Schlesinger, M.J. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  15. Isolation, culture and main characteristics of mouse fat-storing cells: interaction with viruses. Chen, W., Gendrault, J.L., Steffan, A.M., Jeandidier, E., Kirn, A. Hepatology (1989) [Pubmed]
  16. A single nucleotide change in the E2 glycoprotein gene of Sindbis virus affects penetration rate in cell culture and virulence in neonatal mice. Davis, N.L., Fuller, F.J., Dougherty, W.G., Olmsted, R.A., Johnston, R.E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  17. Purification of a multipotent antideath activity from bovine liver and its identification as arginase: nitric oxide-independent inhibition of neuronal apoptosis. Esch, F., Lin, K.I., Hills, A., Zaman, K., Baraban, J.M., Chatterjee, S., Rubin, L., Ash, D.E., Ratan, R.R. J. Neurosci. (1998) [Pubmed]
  18. eps15 and eps15R are essential components of the endocytic pathway. Carbone, R., Fré, S., Iannolo, G., Belleudi, F., Mancini, P., Pelicci, P.G., Torrisi, M.R., Di Fiore, P.P. Cancer Res. (1997) [Pubmed]
  19. Host-dependent variation of asparagine-linked oligosaccharides at individual glycosylation sites of Sindbis virus glycoproteins. Hsieh, P., Rosner, M.R., Robbins, P.W. J. Biol. Chem. (1983) [Pubmed]
  20. GLUT4 phosphorylation and inhibition of glucose transport by dibutyryl cAMP. Piper, R.C., James, D.E., Slot, J.W., Puri, C., Lawrence, J.C. J. Biol. Chem. (1993) [Pubmed]
  21. The immune response in viral encephalitis. Griffin, D.E., Levine, B., Tyor, W.R., Irani, D.N. Semin. Immunol. (1992) [Pubmed]
  22. Hexagonal glycoprotein arrays from Sindbis virus membranes. von Bonsdorff, C.H., Harrison, S.C. J. Virol. (1978) [Pubmed]
  23. Envelope antigens of Sindbis virus in cells infected with temperature-sensitive mutants. Bell, J.W., Waite, M.R. J. Virol. (1977) [Pubmed]
  24. Persistent infection promotes cross-species transmissibility of mouse hepatitis virus. Baric, R.S., Sullivan, E., Hensley, L., Yount, B., Chen, W. J. Virol. (1999) [Pubmed]
  25. High resistance of human parainfluenza type 2 virus protein-expressing cells to the antiviral and anti-cell proliferative activities of alpha/beta interferons: cysteine-rich V-specific domain is required for high resistance to the interferons. Nishio, M., Tsurudome, M., Ito, M., Kawano, M., Komada, H., Ito, Y. J. Virol. (2001) [Pubmed]
  26. Analysis of adaptive mutations in Kunjin virus replicon RNA reveals a novel role for the flavivirus nonstructural protein NS2A in inhibition of beta interferon promoter-driven transcription. Liu, W.J., Chen, H.B., Wang, X.J., Huang, H., Khromykh, A.A. J. Virol. (2004) [Pubmed]
  27. Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. Lenschow, D.J., Giannakopoulos, N.V., Gunn, L.J., Johnston, C., O'Guin, A.K., Schmidt, R.E., Levine, B., Virgin, H.W. J. Virol. (2005) [Pubmed]
  28. Differential regulation of Bcl-2 and Bax expression in cells infected with virulent and nonvirulent strains of sindbis virus. Appel, E., Katzoff, A., Ben-Moshe, T., Kazimirsky, G., Kobiler, D., Lustig, S., Brodie, C. Virology (2000) [Pubmed]
  29. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. Liang, X.H., Kleeman, L.K., Jiang, H.H., Gordon, G., Goldman, J.E., Berry, G., Herman, B., Levine, B. J. Virol. (1998) [Pubmed]
  30. Absence of a cleavable signal sequence in Sindbis virus glycoprotein PE2. Bonatti, S., Blobel, G. J. Biol. Chem. (1979) [Pubmed]
  31. Lethality of PE2 incorporation into Sindbis virus can be suppressed by second-site mutations in E3 and E2. Heidner, H.W., McKnight, K.L., Davis, N.L., Johnston, R.E. J. Virol. (1994) [Pubmed]
  32. Persistence of viral RNA in mouse brains after recovery from acute alphavirus encephalitis. Levine, B., Griffin, D.E. J. Virol. (1992) [Pubmed]
  33. Antigenic comparison of Ockelbo virus isolates from Sweden and Russia with Sindbis virus isolates from Europe, Africa, and Australia: further evidence for variation among alphaviruses. Lundstrom, J.O., Vene, S., Saluzzo, J.F., Niklasson, B. Am. J. Trop. Med. Hyg. (1993) [Pubmed]
  34. Chromatographic removal of viruses from plasma derivatives. Burnouf, T. Dev. Biol. Stand. (1993) [Pubmed]
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