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Gene Review

Nkx2-6  -  NK2 homeobox 6

Mus musculus

Synonyms: AV044928, Homeobox protein NK-2 homolog F, Homeobox protein Nkx-2.6, Nkx-2.6, Nkx2.6, ...
 
 
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High impact information on Nkx2-6

  • Although expression of Nkx2.6 during murine embryogenesis is strongly suggestive of a role for this gene in heart development, mice homozygous for a targeted mutation of Nkx2.6 are normal [1].
  • However, no abnormalities in the pharynges of embryos with mutations in either Nkx2.5 or Nkx2.6 have been reported [2].
  • Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx [2].
  • Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting [3].
  • Interestingly, Nkx3.1 mapped to the central region of the mouse chromosome 14 and was linked to Nkx2.6, a murine homolog of Drosophila tinman [4].
 

Biological context of Nkx2-6

  • These ectopic expression domains resemble the pattern of the Nkx2.6 gene which is closely linked to Nkx3.1 in the mouse genome and its regulation may therefore be affected by the mutation [5].
 

Anatomical context of Nkx2-6

  • Interestingly, in mutant embryos homozygous for Nkx2.6, Nkx2.5 expression extended to the lateral side of the pharynx, suggesting a compensatory function of Nkx2.5 in the mutant pharyngeal pouches [3].
  • 8. Murine Tix/Nkx2.6 mRNA has been detected in the heart and pharyngeal endoderm (this study) [6].
  • Nkx2.6 expression is transiently and specifically restricted to the branchial region of pharyngeal-stage mouse embryos [7].
 

Other interactions of Nkx2-6

References

  1. Common arterial trunk associated with a homeodomain mutation of NKX2.6. Heathcote, K., Braybrook, C., Abushaban, L., Guy, M., Khetyar, M.E., Patton, M.A., Carter, N.D., Scambler, P.J., Syrris, P. Hum. Mol. Genet. (2005) [Pubmed]
  2. Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx. Tanaka, M., Schinke, M., Liao, H.S., Yamasaki, N., Izumo, S. Mol. Cell. Biol. (2001) [Pubmed]
  3. Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting. Tanaka, M., Yamasaki, N., Izumo, S. Mol. Cell. Biol. (2000) [Pubmed]
  4. Nkx3.1, a murine homolog of Ddrosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands. Tanaka, M., Komuro, I., Inagaki, H., Jenkins, N.A., Copeland, N.G., Izumo, S. Dev. Dyn. (2000) [Pubmed]
  5. Targeted disruption of the Nkx3.1 gene in mice results in morphogenetic defects of minor salivary glands: parallels to glandular duct morphogenesis in prostate. Schneider, A., Brand, T., Zweigerdt, R., Arnold, H. Mech. Dev. (2000) [Pubmed]
  6. Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development. Tanaka, M., Kasahara, H., Bartunkova, S., Schinke, M., Komuro, I., Inagaki, H., Lee, Y., Lyons, G.E., Izumo, S. Dev. Genet. (1998) [Pubmed]
  7. Nkx2.6 expression is transiently and specifically restricted to the branchial region of pharyngeal-stage mouse embryos. Nikolova, M., Chen, X., Lufkin, T. Mech. Dev. (1997) [Pubmed]
  8. The murine homeobox genes Nkx2.3 and Nkx2.6 are located on chromosomes 19 and 14, respectively. Copeland, N.G., Jenkins, N.A., Harvey, R.P. Genomics (1994) [Pubmed]
 
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