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Gene Review

Nkx2-3  -  NK2 homeobox 3

Mus musculus

Synonyms: Homeobox protein NK-2 homolog 3, Homeobox protein NK-2 homolog C, Homeobox protein Nkx-2.3, Nkx-2.3, Nkx2-C, ...
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High impact information on Nkx2-3

  • Expression of Nkx2.6 overlaps that of Nkx2.5 in the pharynx and heart and that of Nkx2.3 in the pharynx [1].
  • Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen [2].
  • The homeodomain transcription factor Nkx2-3 is expressed in gut mesenchyme and spleen of embryonic and adult mice [2].
  • Taken together these observations indicate that Nkx2-3 is essential for normal development and functions of the small intestine and spleen [2].
  • Spleens of Nkx2-3 mutants are generally smaller and contain drastically reduced numbers of lymphatic cells [2].

Biological context of Nkx2-3


Anatomical context of Nkx2-3

  • Nkx2-3 was expressed in the pharyngeal floor and pouches, as well as in oral and branchial arch ectoderm [3].
  • Examination of Nkx2-3 null mice revealed defects in maturation and cellular organisation of the sublingual glands [3].
  • Villus formation in the small intestine appears considerably delayed in Nkx2-3(-)/- foetuses due to reduced proliferation of the epithelium, while massively increased growth of crypt cells ensues in surviving adult mutants [2].
  • Architectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responses [5].
  • Furthermore, Nkx2-3(-/-) mice show an excess of conventional B cells in mesenteric lymph node and peritoneal cavity, whereas transitional B cells are rare in spleen but overrepresented in bone marrow [5].

Regulatory relationships of Nkx2-3


Other interactions of Nkx2-3

  • Our data suggest a role for a homeodomain factor in establishing the developmental and positional cues in endothelia that regulate leukocyte homing through local control of cellular adhesion and identify MAdCAM-1 as a candidate target gene of Nkx2-3 [4].
  • The murine homeobox genes Nkx2.3 and Nkx2.6 are located on chromosomes 19 and 14, respectively [6].
  • Collectively, these data indicate a substantial role for Nkx2-3 in the correct association of lymphocytes and splenic stromal elements that is independent of chemokine expression [5].


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