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Gene Review

myo-2  -  Protein MYO-2

Caenorhabditis elegans

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High impact information on myo-2


Biological context of myo-2

  • To further characterize the myosin gene promoters and to examine the types of enhancer sequences in the genome, we have initiated a screen of C. elegans genomic DNA for fragments capable of enhancing the myo-2 promoter [6].
  • This expression pattern suggests CEH-22 plays a key role in pharyngeal muscle-specific activity of the myo-2 enhancer [7].
  • To identify mechanisms regulating gene expression in this tissue, we have characterized a pharyngeal muscle-specific enhancer from myo-2, a myosin heavy chain gene expressed exclusively in pharyngeal muscle [7].

Anatomical context of myo-2


Other interactions of myo-2

  • The validity of the method was confirmed through results with control genes whose expression patterns have been reported; glp-1 in very early embryos, myo-2 in pharyngeal muscle and unc-54 in body wall muscle [9].


  1. Molecular analysis of X chromosome dosage compensation in Caenorhabditis elegans. Donahue, L.M., Quarantillo, B.A., Wood, W.B. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  2. Immunological identification of the genes encoding the four myosin heavy chain isoforms of Caenorhabditis elegans. Miller, D.M., Stockdale, F.E., Karn, J. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  3. The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx. Thatcher, J.D., Haun, C., Okkema, P.G. Development (1999) [Pubmed]
  4. pha-4 is Ce-fkh-1, a fork head/HNF-3alpha,beta,gamma homolog that functions in organogenesis of the C. elegans pharynx. Kalb, J.M., Lau, K.K., Goszczynski, B., Fukushige, T., Moons, D., Okkema, P.G., McGhee, J.D. Development (1998) [Pubmed]
  5. The Caenorhabditis elegans NK-2 homeobox gene ceh-22 activates pharyngeal muscle gene expression in combination with pha-1 and is required for normal pharyngeal development. Okkema, P.G., Ha, E., Haun, C., Chen, W., Fire, A. Development (1997) [Pubmed]
  6. Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans. Okkema, P.G., Harrison, S.W., Plunger, V., Aryana, A., Fire, A. Genetics (1993) [Pubmed]
  7. The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle. Okkema, P.G., Fire, A. Development (1994) [Pubmed]
  8. The Caenorhabditis elegans peb-1 gene encodes a novel DNA-binding protein involved in morphogenesis of the pharynx, vulva, and hindgut. Thatcher, J.D., Fernandez, A.P., Beaster-Jones, L., Haun, C., Okkema, P.G. Dev. Biol. (2001) [Pubmed]
  9. A multi-well version of in situ hybridization on whole mount embryos of Caenorhabditis elegans. Tabara, H., Motohashi, T., Kohara, Y. Nucleic Acids Res. (1996) [Pubmed]
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