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Gene Review

myo-5  -  Protein MYO-5

Caenorhabditis elegans

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High impact information on myosin

  • Multiple lines of evidence support a model in which UNC-98 links integrin-associated proteins to myosin in thick filaments at M-lines [1].
  • Loss of RHO-1 activity causes defects in the early organization of the myosin cytoskeleton but does not inhibit segregation of myosin to the anterior [2].
  • This phenotype was suppressed by inhibiting muscle contraction by a myosin mutation, but it was enhanced by tetramisole-induced hypercontraction [3].
  • We show that a regulatory myosin light chain normally becomes phosphorylated on the apical side of ingressing cells at a conserved site that can lead to myosin-filament formation and contraction of actomyosin networks and that this phosphorylation depends on Wnt signaling [4].
  • Overall, nematode sperm motility illustrates that cell locomotion can be generated by cytoskeletal dynamics alone without the use of myosin-like motor proteins [5].

Associations of myosin with chemical compounds

  • However, particular regions were detected: - a polyglutamine repeat domain in the N-terminal part of the protein, - four peptide sequences associated with GTP-binding sites, - a sequence with slight homology to the rod tail of Caenorhabditis elegans myosin II, -a sequence with homology to a human kinesin motor domain [6].

Other interactions of myosin

  • However, the myosin mutation showed much weaker suppression of the phenotypes of ADF/cofilin or AIP1 mutants than tropomyosin depletion [7].
  • Sperm of the nematode, Ascaris suum, are amoeboid cells that do not require actin or myosin to crawl over solid substrata [8].


  1. UNC-98 links an integrin-associated complex to thick filaments in Caenorhabditis elegans muscle. Miller, R.K., Qadota, H., Landsverk, M.L., Mercer, K.B., Epstein, H.F., Benian, G.M. J. Cell Biol. (2006) [Pubmed]
  2. CDC-42 and RHO-1 coordinate acto-myosin contractility and PAR protein localization during polarity establishment in C. elegans embryos. Schonegg, S., Hyman, A.A. Development (2006) [Pubmed]
  3. Caenorhabditis elegans kettin, a large immunoglobulin-like repeat protein, binds to filamentous actin and provides mechanical stability to the contractile apparatuses in body wall muscle. Ono, K., Yu, R., Mohri, K., Ono, S. Mol. Biol. Cell (2006) [Pubmed]
  4. Wnt/Frizzled Signaling Controls C. elegans Gastrulation by Activating Actomyosin Contractility. Lee, J.Y., Marston, D.J., Walston, T., Hardin, J., Halberstadt, A., Goldstein, B. Curr. Biol. (2006) [Pubmed]
  5. Cytoskeleton dynamics powers nematode sperm motility. Stewart, M., Roberts, T.M. Adv. Protein Chem. (2005) [Pubmed]
  6. Characterization of p80, a novel nuclear and cytoplasmic protein in dinoflagellates. Ausseil, J., Soyer-Gobillard, M.O., Géraud, M.L., Bhaud, Y., Baines, I., Preston, T., Moreau, H. Protist (1999) [Pubmed]
  7. Dual roles of tropomyosin as an F-actin stabilizer and a regulator of muscle contraction in Caenorhabditis elegans body wall muscle. Yu, R., Ono, S. Cell Motil. Cytoskeleton (2006) [Pubmed]
  8. Supramolecular assemblies of the Ascaris suum major sperm protein (MSP) associated with amoeboid cell motility. King, K.L., Stewart, M., Roberts, T.M. J. Cell. Sci. (1994) [Pubmed]
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