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Gene Review

ceh-22  -  Protein CEH-22

Caenorhabditis elegans

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High impact information on ceh-22


Biological context of ceh-22


Physical interactions of ceh-22

  • Multimerized de209 enhances transcription similarly to DE3 specifically in the pharyngeal muscles, suggesting it may be an essential site regulating ceh-22. de209 binds the pan-pharyngeal Forkhead factor PHA-4 in vitro and responds to ectopic pha-4 expression in vivo, suggesting that PHA-4 directly initiates ceh-22 expression through de209 [5].

Other interactions of ceh-22

  • We also examine the relationship between ceh-22 and the pharyngeal organ-specific differentiation gene pha-1 [3].
  • We also present evidence that pha-2 regulates itself positively in pm5 cells, that it is a downstream target of the forkhead gene pha-4, and that it may also act in the isthmus as an inhibitor of the ceh-22 gene, an Nkx2.5 homolog [7].


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