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Gene Review

mua-6  -  Protein MUA-6

Caenorhabditis elegans

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High impact information on mua-6

  • Two other cIFs, IFA-2 and IFA-3, are expressed in epidermal cells [1].
  • In contrast, IFA-2 is not required for embryonic morphogenesis [1].
  • It is shown that mua-6 encodes the cytoplasmic intermediate filament (cIF) A2 protein and that a MUA-6/IFA-2::GFP fusion protein that rescues the presumptive mua-6 null allele localizes to hypodermal hemidesmosomes [2].
  • Although MUA-6/IFA-2 is expressed embryonically, and plays an essential postembryonic role in tissue integrity, it is not required for embryonic development of muscle-cuticle linkages nor for the localization of other cIFs or hemidesmosome-associated proteins in the embryo [2].
  • Fifteen mutations proved to be alleles of previously identified muscle attachment/positioning genes, mup-4, mua-1, mua-5, and mua-6 [3].

Anatomical context of mua-6


  1. Intermediate filaments are required for C. elegans epidermal elongation. Woo, W.M., Goncharov, A., Jin, Y., Chisholm, A.D. Dev. Biol. (2004) [Pubmed]
  2. mua-6, a gene required for tissue integrity in Caenorhabditis elegans, encodes a cytoplasmic intermediate filament. Hapiak, V., Hresko, M.C., Schriefer, L.A., Saiyasisongkhram, K., Bercher, M., Plenefisch, J. Dev. Biol. (2003) [Pubmed]
  3. Mutations affecting nerve attachment of Caenorhabditis elegans. Shioi, G., Shoji, M., Nakamura, M., Ishihara, T., Katsura, I., Fujisawa, H., Takagi, S. Genetics (2001) [Pubmed]
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