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Gene Review

LMNB2  -  lamin B2

Gallus gallus

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Disease relevance of LMNB2


High impact information on LMNB2


Biological context of LMNB2

  • Mitotic reorganization correlates with phosphorylation of the chicken lamin B2 protein by a mitosis-specific yeast lamin kinase with similarities to the mitotic lamin kinase of higher eukaryotes [5].
  • Moreover, phorbol ester treatment of intact cells leads to a substantial reduction of the rate of nuclear import of newly synthesized lamin B2 in vivo [2].
  • Quantitatively, we found that all large endoplasmic reticulum-like membranes present in metaphase cells were decorated with lamin B2-specific antibodies [6].
  • Lamin B2 was expressed in fairly constant amounts in all cell types investigated (except for pachytene-stage germ cells) [7].

Anatomical context of LMNB2


Other interactions of LMNB2

  • Furthermore, we show that in vitro translation of transcripts derived from lamin A and lamin B2 cDNAs yielded polypeptides that were indistinguishable, by two-dimensional gel electrophoresis, from the putative in vivo precursors of lamins A and B2 respectively [8].
  • From these results we conclude that both chicken lamins B1 and B2 may functionally resemble mammalian lamin B. Interestingly, immunolabeling of mitotic cells revealed an association of lamin B2 with extended membrane cisternae that resembled elements of the endoplasmic reticulum [6].
  • At its first level of structural organization, lamin B2 formed "myosin-like" 3.1S dimers consisting of a 52-nm-long tail flanked at one end by two globular heads [1].

Analytical, diagnostic and therapeutic context of LMNB2


  1. Expression of chicken lamin B2 in Escherichia coli: characterization of its structure, assembly, and molecular interactions. Heitlinger, E., Peter, M., Häner, M., Lustig, A., Aebi, U., Nigg, E.A. J. Cell Biol. (1991) [Pubmed]
  2. Phosphorylation on protein kinase C sites inhibits nuclear import of lamin B2. Hennekes, H., Peter, M., Weber, K., Nigg, E.A. J. Cell Biol. (1993) [Pubmed]
  3. Disassembly of in vitro formed lamin head-to-tail polymers by CDC2 kinase. Peter, M., Heitlinger, E., Häner, M., Aebi, U., Nigg, E.A. EMBO J. (1991) [Pubmed]
  4. The CaaX motif is required for isoprenylation, carboxyl methylation, and nuclear membrane association of lamin B2. Kitten, G.T., Nigg, E.A. J. Cell Biol. (1991) [Pubmed]
  5. p34cdc2 acts as a lamin kinase in fission yeast. Enoch, T., Peter, M., Nurse, P., Nigg, E.A. J. Cell Biol. (1991) [Pubmed]
  6. The fates of chicken nuclear lamin proteins during mitosis: evidence for a reversible redistribution of lamin B2 between inner nuclear membrane and elements of the endoplasmic reticulum. Stick, R., Angres, B., Lehner, C.F., Nigg, E.A. J. Cell Biol. (1988) [Pubmed]
  7. Differential expression of nuclear lamin proteins during chicken development. Lehner, C.F., Stick, R., Eppenberger, H.M., Nigg, E.A. J. Cell Biol. (1987) [Pubmed]
  8. A second higher vertebrate B-type lamin. cDNA sequence determination and in vitro processing of chicken lamin B2. Vorburger, K., Lehner, C.F., Kitten, G.T., Eppenberger, H.M., Nigg, E.A. J. Mol. Biol. (1989) [Pubmed]
  9. The single nuclear lamin of Caenorhabditis elegans forms in vitro stable intermediate filaments and paracrystals with a reduced axial periodicity. Karabinos, A., Schünemann, J., Meyer, M., Aebi, U., Weber, K. J. Mol. Biol. (2003) [Pubmed]
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