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Gene Review

Lmnb2  -  lamin B2

Mus musculus

Synonyms: Lamin-B2, lamin B3
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High impact information on Lmnb2


Biological context of Lmnb2

  • Concomitantly, although nuclear import of the mutant lamin B2 proteins was preserved, their association with the inner nuclear membrane was severely impaired [2].
  • Furthermore, these Ku-deficient cells had a 4.5-, 3.4- and 4.3-fold decrease in nascent strand DNA abundance at the lamin B2, beta-globin and c-myc replication origins, respectively [4].
  • We have previously shown that a cell cycle-dependent nucleoprotein complex assembles in vivo on a 74 bp sequence within the human DNA replication origin associated to the Lamin B2 gene [5].
  • The VNTR is adjacent to exon 8 of the lamin B2 gene which, albeit encoding the nuclear localization signal of the protein, is highly divergent both at amino acid and nucleotide level among species [6].

Anatomical context of Lmnb2

  • RT-PCR experiments carried out on HeLa cell RNA suggest that none of the downstream junctions is used during the processing of the lamin B2 pre-mRNA [6].

Regulatory relationships of Lmnb2

  • Lamin B2 is coexpressed with lamin B1 (formerly termed lamin B) in all somatic cells and mammalian species that we analysed, including a variety of cells currently believed to contain only a single lamin [7].

Analytical, diagnostic and therapeutic context of Lmnb2


  1. cDNA cloning of a germ cell specific lamin B3 from mouse spermatocytes and analysis of its function by ectopic expression in somatic cells. Furukawa, K., Hotta, Y. EMBO J. (1993) [Pubmed]
  2. The CaaX motif is required for isoprenylation, carboxyl methylation, and nuclear membrane association of lamin B2. Kitten, G.T., Nigg, E.A. J. Cell Biol. (1991) [Pubmed]
  3. Identification of lamin B2 as a substrate of protein kinase C in BALB/MK-2 mouse keratinocytes. Kasahara, K., Chida, K., Tsunenaga, M., Kohno, Y., Ikuta, T., Kuroki, T. J. Biol. Chem. (1991) [Pubmed]
  4. Decreased origin usage and initiation of DNA replication in haploinsufficient HCT116 Ku80+/- cells. Sibani, S., Price, G.B., Zannis-Hadjopoulos, M. J. Cell. Sci. (2005) [Pubmed]
  5. Selection of homeotic proteins for binding to a human DNA replication origin. de Stanchina, E., Gabellini, D., Norio, P., Giacca, M., Peverali, F.A., Riva, S., Falaschi, A., Biamonti, G. J. Mol. Biol. (2000) [Pubmed]
  6. A repeated element in the human lamin B2 gene covers most of an intron and reiterates the exon/intron junction. de Stanchina, E., Perini, G., Patrone, G., Suarez-Covarrubias, A., Riva, S., Biamonti, G. Gene (1997) [Pubmed]
  7. Characterization of a second highly conserved B-type lamin present in cells previously thought to contain only a single B-type lamin. Höger, T.H., Zatloukal, K., Waizenegger, I., Krohne, G. Chromosoma (1990) [Pubmed]
  8. Gene structure and chromosomal localization of the murine lamin B2 gene. Zewe, M., Höger, T.H., Fink, T., Lichter, P., Krohne, G., Franke, W.W. Eur. J. Cell Biol. (1991) [Pubmed]
  9. Dynamic properties of germ line-specific lamin B3: the role of the shortened rod domain. Schütz, W., Benavente, R., Alsheimer, M. Eur. J. Cell Biol. (2005) [Pubmed]
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