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Gene Review

LamC  -  Lamin C

Drosophila melanogaster

Synonyms: CG10119, DmC, Dmel\CG10119, G-IF, LAMC, ...
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High impact information on LamC


Biological context of LamC


Anatomical context of LamC

  • The antibodies decorate the nuclear envelope in Drosophila Kc tissue culture cells as well as in salivary and accessory glands demonstrating that pG-IF encodes a nuclear lamin (lamin C) [3].
  • In addition, we analyzed the polymer formation of two Drosophila lamin C mutants and found that a segment in the carboxy-terminal tail domain is required for assembly of lamin C paracrystals at the nuclear lamina [8].

Regulatory relationships of LamC

  • Kc cells contain products of both lamin genes, the lamin Dm0 gene encoding constitutive polypeptides expressed in almost all cell types and the developmentally regulated lamin C gene [9].
  • A null mutation of the dcp-1 gene, one of the two known Drosophila caspase genes, also results in development of melanotic tumors and larval death, suggesting that the ectopically expressed lamin C inhibits apoptosis through competitive inhibition of caspase activity [6].

Other interactions of LamC

  • Expression of Drosophila lamin C is similar to that of vertebrate lamin A (plus C), which loses its CaaX motif during incorporation into the lamina [3].

Analytical, diagnostic and therapeutic context of LamC


  1. Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope. Libotte, T., Zaim, H., Abraham, S., Padmakumar, V.C., Schneider, M., Lu, W., Munck, M., Hutchison, C., Wehnert, M., Fahrenkrog, B., Sauder, U., Aebi, U., Noegel, A.A., Karakesisoglou, I. Mol. Biol. Cell (2005) [Pubmed]
  2. Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C. Lin, F., Worman, H.J. J. Biol. Chem. (1993) [Pubmed]
  3. Expression of Drosophila lamin C is developmentally regulated: analogies with vertebrate A-type lamins. Riemer, D., Stuurman, N., Berrios, M., Hunter, C., Fisher, P.A., Weber, K. J. Cell. Sci. (1995) [Pubmed]
  4. A cDNA from Drosophila melanogaster encodes a lamin C-like intermediate filament protein. Bossie, C.A., Sanders, M.M. J. Cell. Sci. (1993) [Pubmed]
  5. Molecular genetic analysis of the nested Drosophila melanogaster lamin C gene. Schulze, S.R., Curio-Penny, B., Li, Y., Imani, R.A., Rydberg, L., Geyer, P.K., Wallrath, L.L. Genetics (2005) [Pubmed]
  6. Ectopic overexpression of Drosophila lamin C is stage-specific lethal. Stuurman, N., Delbecque, J.P., Callaerts, P., Aebi, U. Exp. Cell Res. (1999) [Pubmed]
  7. The organization of the gene for Drosophila lamin C: limited homology with vertebrate lamin genes and lack of homology versus the Drosophila lamin Dmo gene. Riemer, D., Weber, K. Eur. J. Cell Biol. (1994) [Pubmed]
  8. Assembly of Drosophila lamin Dm0 and C mutant proteins studied with the baculovirus system. Krohne, G., Stuurman, N., Kempf, A. Eur. J. Cell Biol. (1998) [Pubmed]
  9. In vivo phosphorylation of Drosophila melanogaster nuclear lamins during both interphase and mitosis. Rzepecki, R., Fisher, P.A. Cell. Mol. Biol. Lett. (2002) [Pubmed]
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