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Gene Review:

Orm3 - orosomucoid 3

Mus musculus

Synonyms: AGP 3, Agp-3, Alpha-1-acid glycoprotein 3, OMD 3, Orm-3, ...

Shirai, T. et al., Chang, C.J. et al., Cheng, T.L. et al., Cheng, T.L. et al., Cheng, T.L. et al., et al.

Cheng, Cheng, Chen, Tsao, Chuang, Hsiao, Lin, Roffler,

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Disease relevance of Orm3

In addition, AGP3 clearance of betaG-sPEG before administration of BHAMG, a glucuronide prodrug of p-hydroxyaniline mustard, prevented toxicity associated with systemic activation of the prodrug based on mouse weight and blood cell numbers [1].

High impact information on Orm3

In (NZB X NZW)F1 mice, a single dominant locus from the NZW strain, Agp-3, intensified the magnitude of gp70 IC formation, and a combined effect of 2 unlinked dominant loci from the NZW strain, Ads-3 and Ads-4, acted to increase the serum titers of anti-dsDNA antibodies [2].
Intravenous administration of AGP3, an IgM mAb against methoxypoly(ethylene glycol), accelerated clearance of conjugate from serum and increased the tumor/blood ratio of B72 [3].
3-betaG-PEG followed 48 h later with AGP3 and a glucuronide prodrug of p-hydroxyaniline mustard significantly (p< or =0.0005) delayed tumor growth with minimal toxicity compared to therapy with a control conjugate or conventional chemotherapy [3].
An IgM monoclonal antibody (AGP3) against polyethylene glycol (PEG) was used to assay PEG-modified proteins by ELISA [4].
The major structural differences between AGP-2 and AGP-3 genes are located in introns 1 and 5 [5].

Biological context of Orm3

This study clearly indicates that the NZW loci Agp-3 and Ads-3 exist in common or are tightly linked on chromosome 17, are closely linked to the H-2 complex, and are associated with the severity of renal disease in (NZB X NZW)F1 hybrids.(ABSTRACT TRUNCATED AT 250 WORDS)[2]
The molecular basis of the low level expression of AGP-3 and the possible classification of AGP-3 as a pseudogene are discussed [5].

Associations of Orm3 with chemical compounds

AGP3 should be generally useful for accelerating the clearance of PEG-modified proteins as well as for improving the tumor/blood ratios of antibody-betaG-PEG conjugates for glucuronide prodrug therapy of cancer [1].

Analytical, diagnostic and therapeutic context of Orm3

The low level of AGP-3 mRNA can be detected by the polymerase chain reaction (PCR) [5].
Here we report the genomic organization of three M. domesticus AGP genes, the sequence analysis of the AGP-3 genomic DNA, and the expression of the AGP-3 gene [5].
A sandwich ELISA in which E11/AGP3 were employed as the capture/detection antibodies was developed to detect PEG-modified proteins at concentrations as low as 1.2 ng/mL [6].

References

Accelerated clearance of polyethylene glycol-modified proteins by anti-polyethylene glycol IgM. Cheng, T.L., Wu, P.Y., Wu, M.F., Chern, J.W., Roffler, S.R. Bioconjug. Chem. (1999) [Pubmed]
Naturally occurring antibody response to DNA is associated with the response to retroviral gp70 in autoimmune New Zealand mice. Shirai, T., Ohta, K., Kohno, A., Furukawa, F., Yoshida, H., Maruyama, N., Hirose, S. Arthritis Rheum. (1986) [Pubmed]
Efficient clearance of poly(ethylene glycol)-modified immunoenzyme with anti-PEG monoclonal antibody for prodrug cancer therapy. Cheng, T.L., Chen, B.M., Chern, J.W., Wu, M.F., Roffler, S.R. Bioconjug. Chem. (2000) [Pubmed]
Sensitive measurement of polyethylene glycol-modified proteins. Tsai, N.M., Cheng, T.L., Roffler, S.R. BioTechniques (2001) [Pubmed]
Structure and expression of mouse alpha 1-acid glycoprotein gene-3 (AGP-3). Chang, C.J., Lai, M.Y., Chen, D.S., Lee, S.C. DNA Cell Biol. (1992) [Pubmed]
Monoclonal antibody-based quantitation of poly(ethylene glycol)-derivatized proteins, liposomes, and nanoparticles. Cheng, T.L., Cheng, C.M., Chen, B.M., Tsao, D.A., Chuang, K.H., Hsiao, S.W., Lin, Y.H., Roffler, S.R. Bioconjug. Chem. (2005) [Pubmed]

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