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Gene Review:

Pigf - phosphatidylinositol glycan anchor...

Mus musculus

Synonyms: PIG-F, Phosphatidylinositol-glycan biosynthesis class F protein

Achen, M.G. et al., Cao, Y. et al., Itokawa, T. et al., Ohishi, K. et al.

Achen, Gad, Stacker, Wilks,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Pigf

The expression of VEGF mRNA and protein is drastically up-regulated by hypoxia in choriocarcinoma cells, whereas expression of PIGF is not affected by the low concentration of oxygen [1].

High impact information on Pigf

The Pigf gene consists of six exons spanning 30 kb and was mapped to chromosome 17 at 17E4-E5 [2].
The secretion of PIGF and VEGF by trophoblastic giant cells is likely to be the signal which initiates and co-ordinates vascularization in the deciduum and placenta during early embryogenesis [3].
Transcripts encoding mouse PIGF were abundant in trophoblastic giant cells associated with the parietal yolk sac at early stages of embryogenesis [3].
The pattern of PIGF gene expression in mouse embryos was studied by in situ hybridization [3].
And angiogenesis induced by PIGF in a Matrigel plug assay was inhibited by administration of SU5416 [4].

Anatomical context of Pigf

VEGF transcripts were also detected in trophoblastic giant cells raising the possibility that these cells may secrete heterodimers consisting of one PIGF subunit and one VEGF subunit [3].

References

In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor. Cao, Y., Linden, P., Shima, D., Browne, F., Folkman, J. J. Clin. Invest. (1996) [Pubmed]
Cloning and characterization of the murine GPI anchor synthesis gene Pigf, a homologue of the human PIGF gene. Ohishi, K., Kurimoto, Y., Inoue, N., Endo, Y., Takeda, J., Kinoshita, T. Genomics (1996) [Pubmed]
Placenta growth factor and vascular endothelial growth factor are co-expressed during early embryonic development. Achen, M.G., Gad, J.M., Stacker, S.A., Wilks, A.F. Growth Factors (1997) [Pubmed]
Antiangiogenic effect by SU5416 is partly attributable to inhibition of Flt-1 receptor signaling. Itokawa, T., Nokihara, H., Nishioka, Y., Sone, S., Iwamoto, Y., Yamada, Y., Cherrington, J., McMahon, G., Shibuya, M., Kuwano, M., Ono, M. Mol. Cancer Ther. (2002) [Pubmed]

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