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Gene Review

PIGF  -  phosphatidylinositol glycan anchor...

Homo sapiens

Synonyms: GPI11 homolog, PIG-F, Phosphatidylinositol-glycan biosynthesis class F protein
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Disease relevance of PIGF

  • The presence of the PIGF mRNA in thyroid, placenta, lung, and goiter has indicated the tissues where this factor functions [1].
  • CONCLUSIONS: Decreased serum levels of VEGF and PIGF characterise, and therefore seem to be of importance during (the development of), pre-eclampsia [2].
  • These results suggest that PIGF may contribute to the pathogenesis of brain tumor angiogenesis [3].
  • We conducted hypoxic experiments with cultured U-251MG human glioma cells to determine the mechanism of PIGF gene regulation [3].
  • CONCLUSION: These findings suggest that in the first trimester of pregnancy the level of maternal PIGF was already significantly increased not only in pregnancies complicated by noninsulin dependent diabetes but also in those with gestational diabetes [4].

High impact information on PIGF


Biological context of PIGF


Anatomical context of PIGF

  • Finally, we demonstrate that VEGF up-regulation may occur at the RNA level since no gene amplification is observed; conversely, in in vitro models such as the embryonal stem cell line NTERA-2 and the choricarcinoma JEG-3 cell line, VEGF (but not PIGF) mRNA expression is regulated by hypoxic stress [7].
  • There was a significant increase in the levels of VEGF secreted fromfirst trimester and term cytotrophoblast cells cultured under lowered oxygen conditions compared to the controls while there was a significant decrease in the secreted levels of PIGF in the same cell populations (as measured by ELISA) [11].
  • Placenta-like growth factor (PIGF) expression is increased while trophoblast proliferation is reduced, suggesting "hyperoxia" in the placental villous tree [12].

Associations of PIGF with chemical compounds

  • The placental-derived growth factor (PIGF) is a dimeric glycoprotein showing a high degree of sequence similarity to the vascular endothelial growth factor [1].
  • One of the human GPI synthesis genes, PIGF (phosphatidylinositol glycan complementation class F), which is involved late in the synthesis pathway, has been cloned [13].

Other interactions of PIGF


  1. Placenta growth factor-1 is chemotactic, mitogenic, and angiogenic. Ziche, M., Maglione, D., Ribatti, D., Morbidelli, L., Lago, C.T., Battisti, M., Paoletti, I., Barra, A., Tucci, M., Parise, G., Vincenti, V., Granger, H.J., Viglietto, G., Persico, M.G. Lab. Invest. (1997) [Pubmed]
  2. Selective deficit of angiogenic growth factors characterises pregnancies complicated by pre-eclampsia. Reuvekamp, A., Velsing-Aarts, F.V., Poulina, I.E., Capello, J.J., Duits, A.J. British journal of obstetrics and gynaecology. (1999) [Pubmed]
  3. Placenta growth factor (PlGF) mRNA expression in brain tumors. Nomura, M., Yamagishi, S., Harada, S., Yamashima, T., Yamashita, J., Yamamoto, H. J. Neurooncol. (1998) [Pubmed]
  4. Maternal serum level of placental growth factor in diabetic pregnancies. Ong, C.Y., Lao, T.T., Spencer, K., Nicolaides, K.H. The Journal of reproductive medicine. (2004) [Pubmed]
  5. Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. Hong, Y., Maeda, Y., Watanabe, R., Inoue, N., Ohishi, K., Kinoshita, T. J. Biol. Chem. (2000) [Pubmed]
  6. Glycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p-deficient yeast suggest a branched pathway and implicate gpi13p in phosphoethanolamine transfer to the third mannose. Taron, C.H., Wiedman, J.M., Grimme, S.J., Orlean, P. Mol. Biol. Cell (2000) [Pubmed]
  7. Neovascularization in human germ cell tumors correlates with a marked increase in the expression of the vascular endothelial growth factor but not the placenta-derived growth factor. Viglietto, G., Romano, A., Maglione, D., Rambaldi, M., Paoletti, I., Lago, C.T., Califano, D., Monaco, C., Mineo, A., Santelli, G., Manzo, G., Botti, G., Chiappetta, G., Persico, M.G. Oncogene (1996) [Pubmed]
  8. Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1. Hong, Y., Ohishi, K., Inoue, N., Endo, Y., Fujita, T., Takeda, J., Kinoshita, T. Genomics (1997) [Pubmed]
  9. Structure and chromosomal localization of the GPI-anchor synthesis gene PIGF and its pseudogene psi PIGF. Ohishi, K., Inoue, N., Endo, Y., Fujita, T., Takeda, J., Kinoshita, T. Genomics (1995) [Pubmed]
  10. Expression cloning of genes for GPI-anchor biosynthesis. Kinoshita, T., Takahashi, M., Inoue, N., Miyata, T., Takeda, J. Braz. J. Med. Biol. Res. (1994) [Pubmed]
  11. Vascular endothelial growth factor and placental growth factor release in cultured trophoblast cells under different oxygen tensions. Lash, G.E., Taylor, C.M., Trew, A.J., Cooper, S., Anthony, F.W., Wheeler, T., Baker, P.N. Growth Factors (2002) [Pubmed]
  12. Oxygen and placental vascular development. Kingdom, J.C., Kaufmann, P. Adv. Exp. Med. Biol. (1999) [Pubmed]
  13. Cloning and characterization of the murine GPI anchor synthesis gene Pigf, a homologue of the human PIGF gene. Ohishi, K., Kurimoto, Y., Inoue, N., Endo, Y., Takeda, J., Kinoshita, T. Genomics (1996) [Pubmed]
  14. Isolation and characterization of a new cell line from a renal carcinoma bone metastasis. Avnet, S., Cenni, E., Granchi, D., Perut, F., Amato, I., Battistelli, L., Brandi, M.L., Giunti, A., Baldini, N. Anticancer Res. (2004) [Pubmed]
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