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Gene Review

Bsnd  -  barttin CLCNK-type chloride channel...

Rattus norvegicus

Synonyms: Barttin
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Disease relevance of Bsnd

  • Recently, mutations in barttin, a protein not related to any known ion transporter or channel, were described in BSND, a variant of Bartter syndrome associated with sensorineural deafness [1].

High impact information on Bsnd


Biological context of Bsnd


Associations of Bsnd with chemical compounds

  • Microdissection of the inner medullary collecting duct and thin limb of Henle's loop followed by real-time PCR revealed that CLC-K1 and barttin mRNA regulation in inner medulla was limited to the thin limb; mRNA levels in collecting ducts were not affected by furosemide treatment [3].

Other interactions of Bsnd

  • Localisation and regulation of ClC-K1 and barttin mRNA was analysed by RNase protection and in situ hybridisation [3].

Analytical, diagnostic and therapeutic context of Bsnd


  1. Barttin increases surface expression and changes current properties of ClC-K channels. Waldegger, S., Jeck, N., Barth, P., Peters, M., Vitzthum, H., Wolf, K., Kurtz, A., Konrad, M., Seyberth, H.W. Pflugers Arch. (2002) [Pubmed]
  2. Selectively reduced expression of thick ascending limb Tamm-Horsfall protein in hypothyroid kidneys. Schmitt, R., Kahl, T., Mutig, K., Bachmann, S. Histochem. Cell Biol. (2004) [Pubmed]
  3. Parallel down-regulation of chloride channel CLC-K1 and barttin mRNA in the thin ascending limb of the rat nephron by furosemide. Wolf, K., Meier-Meitinger, M., Bergler, T., Castrop, H., Vitzthum, H., Riegger, G.A., Kurtz, A., Krämer, B.K. Pflugers Arch. (2003) [Pubmed]
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