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Gene Review

Pex2  -  peroxisomal biogenesis factor 2

Mus musculus

Synonyms: D3Ertd138e, PAF-1, PMP35, Paf1, Peroxin-2, ...
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Disease relevance of Pxmp3


High impact information on Pxmp3


Biological context of Pxmp3


Associations of Pxmp3 with chemical compounds

  • The rate of cholesterol biosynthesis in 7- to 9-day-old PEX2(-/-) mice is markedly increased in most tissues, except in the brain and kidneys, where it is reduced [2].
  • It is also shown that the contractility evoked by the addition of SNP was not due to production of PAF, because its antagonist, WEB 2086 (10-30 mumol/L, a concentration that blocked contractions evoked by PAF 1 nmol/L), had no effect on the SNP-evoked contractions [5].

Analytical, diagnostic and therapeutic context of Pxmp3


  1. Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a model for Zellweger syndrome, a human neuronal migration disorder. Faust, P.L., Hatten, M.E. J. Cell Biol. (1997) [Pubmed]
  2. Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse model. Kovacs, W.J., Shackelford, J.E., Tape, K.N., Richards, M.J., Faust, P.L., Fliesler, S.J., Krisans, S.K. Mol. Cell. Biol. (2004) [Pubmed]
  3. Novel testis-specific protein-DNA interactions activate transcription of the mouse protamine 2 gene during spermatogenesis. Yiu, G.K., Hecht, N.B. J. Biol. Chem. (1997) [Pubmed]
  4. Structure and expression of mammalian peroxisome assembly factor-1 (PMP35) genes. Wilson, G.N., Bryant, D.D. Biochem. Med. Metab. Biol. (1994) [Pubmed]
  5. Nitroprusside stimulates contractility and the synthesis of 14C-acetylated PAF-like substances in estrogen primed-mouse uterine horns. Martínez, L., Gimeno, M.F., Villán, L., Villar, M., Rudolph, M.I. Prostaglandins Other Lipid Mediat. (1999) [Pubmed]
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