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Chemical Compound Review

Nipride     disodium; iron; oxoazanide; pentacyanide

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Disease relevance of Nipride

  • Lordosis facilitated by P or SNP was blocked by injection of LHRH antiserum into the 3V [1].
  • Hemoglobin pretreatment also blocked the increase in intracellular calcium levels due to SNP (10 nmol/L) or hypoxia [2].
  • In contrast, a single bolus of SNP in the striatal region caused neuronal death and demyelination as early as 1 to 3 days following the infusion with the NO donor [3].
  • SOD overexpression provided less protection against the toxicity of SNAP and SNP than overexpression of GPX but was more effective in protecting against SIN-1 [4].
  • The rise in CVC with low-dose SNP (deltaCVC) was significantly greater in Site B and Site C during hyperthermia compared to normothermia (P < 0.05) [5].

Psychiatry related information on Nipride

  • Both modes of SNP treatment also inhibited expression of maternal behavior [6].
  • Similarly, SNP (1 mg/kg) reversed the decrease in reaction time by L-NAME-codeine to its control values, significantly [7].
  • The time-course and onset of erection was concurrent with the stimulation by exogenous NO (SNP), suggesting that this new pharmacologic mechanism of soluble guanylyl cyclase stimulation could be used in the treatment of erectile dysfunction [8].

High impact information on Nipride

  • Moreover, expressing a constitutively active form of MKK3, a direct activator of p38 MAP kinase promoted Bax translocation and cell death in the absence of SNP [9].
  • Bax-deficient cortical neurons were resistant to SNP, further demonstrating the necessity of Bax in this mode of cell death [9].
  • The addition of SNP or SNAP to VSMC cultures at the time of serum stimulation abrogates the induction of cdk2 activity without suppressing protein levels of cdk2 or cyclin E. These NO donors block serum-stimulated upregulation of cyclin A mRNA and protein and repress the serum induction of cyclin A promoter activity in VSMCs [10].
  • CONCLUSIONS: The addition of the nitric oxide donors SNP or SNAP to mitogen-stimulated VSMCs prevents activation of cdk2, a key regulator of the G1 and S phases of the cell cycle [10].
  • SNP and SNAP also repress the mitogen-stimulated activation of the cyclin A promoter [10].

Chemical compound and disease context of Nipride


Biological context of Nipride


Anatomical context of Nipride

  • A role for p38 MAP kinase was further substantiated by the observation that SB203580 blocked translocation of the cell death activator, Bax, from the cytosol to the mitochondria after treatment with SNP [9].
  • Moreover, the potency of glyceryl trinitrate (n3Gro) and sodium nitroprusside (SNP) as relaxing agents and the ability of SNP to induce increases in cGMP in aortic rings were significantly enhanced in those rings denuded of endothelium or treated with the inhibitors [20].
  • After thrombolysis, coronary artery reocclusion developed in all reperfused dogs in the saline group (30 +/- 8 minutes) and in the L-NNA group (48 +/- 12 minutes), in 3 (of 4) reperfused dogs in the L-arginine group (123 +/- 26 minutes), and in 3 (of 4) reperfused dogs in the SNP group (128 +/- 19 minutes) (P < .01) [21].
  • LBF increased in a dose-dependent fashion in response to the femoral artery infusions of MCh and SNP (P<.001) [22].
  • Significant constriction of the great vessels and ductus arteriosus was observed with L-NIL, whereas both LPS and SNP dilated these vessels [23].

Associations of Nipride with other chemical compounds


Gene context of Nipride


Analytical, diagnostic and therapeutic context of Nipride


  1. Nitric oxide mediates sexual behavior in female rats. Mani, S.K., Allen, J.M., Rettori, V., McCann, S.M., O'Malley, B.W., Clark, J.H. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Nitric oxide-mediated augmentation of polymorphonuclear free radical generation after hypoxia-reoxygenation. Sethi, S., Singh, M.P., Dikshit, M. Blood (1999) [Pubmed]
  3. Effects of TNF-alpha and IFN-gamma on nitric oxide-induced neurotoxicity in the mouse brain. Blais, V., Rivest, S. J. Immunol. (2004) [Pubmed]
  4. Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells. Tiedge, M., Lortz, S., Munday, R., Lenzen, S. Diabetologia (1999) [Pubmed]
  5. Nitric oxide is not permissive for cutaneous active vasodilatation in humans. Wilkins, B.W., Holowatz, L.A., Wong, B.J., Minson, C.T. J. Physiol. (Lond.) (2003) [Pubmed]
  6. Nitric oxide prolongs parturition and inhibits maternal behavior in rats. Okere, C.O., Higuchi, T., Kaba, H., Russell, J.A., Okutani, F., Takahashi, S., Murata, T. Neuroreport (1996) [Pubmed]
  7. Modification by L-NAME of codeine induced analgesia: possible role of nitric oxide. Khattab, M.M., El-Hadiyah, T.M., Al-Shabanah, O.A., Raza, M. Recept. Channels (2004) [Pubmed]
  8. BAY 41-2272: a stimulator of soluble guanylyl cyclase induces nitric oxide-dependent penile erection in vivo. Bischoff, E., Schramm, M., Straub, A., Feurer, A., Stasch, J.P. Urology (2003) [Pubmed]
  9. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. Ghatan, S., Larner, S., Kinoshita, Y., Hetman, M., Patel, L., Xia, Z., Youle, R.J., Morrison, R.S. J. Cell Biol. (2000) [Pubmed]
  10. Nitric oxide-induced downregulation of Cdk2 activity and cyclin A gene transcription in vascular smooth muscle cells. Guo, K., Andrés, V., Walsh, K. Circulation (1998) [Pubmed]
  11. Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons. Bastianetto, S., Zheng, W.H., Quirion, R. Br. J. Pharmacol. (2000) [Pubmed]
  12. Involvement of nitric oxide in cardiorespiratory regulation in the nucleus tractus solitarii. Vitagliano, S., Berrino, L., D'Amico, M., Maione, S., De Novellis, V., Rossi, F. Neuropharmacology (1996) [Pubmed]
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  14. 3', 4'-dihydroxyflavonol enhances nitric oxide bioavailability and improves vascular function after ischemia and reperfusion injury in the rat. Chan, E.C., Drummond, G.R., Woodman, O.L. J. Cardiovasc. Pharmacol. (2003) [Pubmed]
  15. The ability to bind albumin is correlated with nitric oxide sensitivity in Moraxella catarrhalis. Maluszynska, G.M., Krachler, B., Sundqvist, T. FEMS Microbiol. Lett. (1998) [Pubmed]
  16. Nitric oxide/cAMP interactions in the control of rat renal vascular resistance. Sandner, P., Kornfeld, M., Ruan, X., Arendshorst, W.J., Kurtz, A. Circ. Res. (1999) [Pubmed]
  17. Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide. Tamatani, M., Ogawa, S., Nuñez, G., Tohyama, M. Cell Death Differ. (1998) [Pubmed]
  18. Down-regulation of survivin in nitric oxide-induced cell growth inhibition and apoptosis of the human lung carcinoma cells. Chao, J.I., Kuo, P.C., Hsu, T.S. J. Biol. Chem. (2004) [Pubmed]
  19. Induction of nitric oxide synthase mRNA expression. Suppression by exogenous nitric oxide. Colasanti, M., Persichini, T., Menegazzi, M., Mariotto, S., Giordano, E., Caldarera, C.M., Sogos, V., Lauro, G.M., Suzuki, H. J. Biol. Chem. (1995) [Pubmed]
  20. Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Moncada, S., Rees, D.D., Schulz, R., Palmer, R.M. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  21. Endogenous and exogenous nitric oxide protect against intracoronary thrombosis and reocclusion after thrombolysis. Yao, S.K., Akhtar, S., Scott-Burden, T., Ober, J.C., Golino, P., Buja, L.M., Casscells, W., Willerson, J.T. Circulation (1995) [Pubmed]
  22. Endothelial dysfunction is associated with cholesterol levels in the high normal range in humans. Steinberg, H.O., Bayazeed, B., Hook, G., Johnson, A., Cronin, J., Baron, A.D. Circulation (1997) [Pubmed]
  23. Inducible nitric oxide synthase and the regulation of central vessel caliber in the fetal rat. Bustamante, S.A., Pang, Y., Romero, S., Pierce, M.R., Voelker, C.A., Thompson, J.H., Sandoval, M., Liu, X., Miller, M.J. Circulation (1996) [Pubmed]
  24. Differential effects of nitric oxide on erythroid and myeloid colony growth from CD34+ human bone marrow cells. Shami, P.J., Weinberg, J.B. Blood (1996) [Pubmed]
  25. Nitric oxide can increase heart rate by stimulating the hyperpolarization-activated inward current, I(f). Musialek, P., Lei, M., Brown, H.F., Paterson, D.J., Casadei, B. Circ. Res. (1997) [Pubmed]
  26. Overexpression of protein kinase C isoforms protects RAW 264.7 macrophages from nitric oxide-induced apoptosis: involvement of c-Jun N-terminal kinase/stress-activated protein kinase, p38 kinase, and CPP-32 protease pathways. Jun, C.D., Oh, C.D., Kwak, H.J., Pae, H.O., Yoo, J.C., Choi, B.M., Chun, J.S., Park, R.K., Chung, H.T. J. Immunol. (1999) [Pubmed]
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  28. Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kappaB. Chun, K.S., Cha, H.H., Shin, J.W., Na, H.K., Park, K.K., Chung, W.Y., Surh, Y.J. Carcinogenesis (2004) [Pubmed]
  29. Exogenous nitric oxide stimulates cell proliferation via activation of a mitogen-activated protein kinase pathway in ovine fetoplacental artery endothelial cells. Zheng, J., Wen, Y., Austin, J.L., Chen, D.B. Biol. Reprod. (2006) [Pubmed]
  30. Cyclic GMP-independent mechanisms contribute to the inhibition of platelet adhesion by nitric oxide donor: a role for alpha-actinin nitration. Marcondes, S., Cardoso, M.H., Morganti, R.P., Thomazzi, S.M., Lilla, S., Murad, F., De Nucci, G., Antunes, E. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  31. Regulation of p53 by activated protein kinase C-delta during nitric oxide-induced dopaminergic cell death. Lee, S.J., Kim, D.C., Choi, B.H., Ha, H., Kim, K.T. J. Biol. Chem. (2006) [Pubmed]
  32. Modulatory effect of guanosine-3':5' cyclic monophosphate on macrophage susceptibility to Trypanosoma cruzi infection. Wirth, J.J., Kierszenbaum, F. J. Immunol. (1983) [Pubmed]
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