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Gene Review:

Rb(X.2)2Ad - Robertsonian translocation, Chr X and 2,...

Mus musculus

Tease, C. et al., Tada, T. et al., Speirs, S. et al., Webb, S. et al., Tease, C. et al., et al.

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High impact information on Rb(X.2)2Ad

Two male fertile translocations [Rb(X.2)2Ad and Rb(X.9)6H] and a male sterile translocation [Rb(X.12)7H] were used [1].
To examine the effects of X-chromosome imprinting during early mouse embryogenesis, we attempted to produce XM0, XP0, XMXMY, XMXPY and XMXMXP (where XM and XP stand for the maternally and the paternally derived X chromosome, respectively) making use of mouse strains bearing the translocation Rb(X.2)2Ad and the inversion In(X)1H [2].
(C57BL x CBA)F1 hybrid female mice were mated with hemizygous Rb(X.2)2Ad males to distinguish the paternal X chromosome [3].
Cytogenetic analyses of metaphase II stage oocytes showed elevated rates of hyperhaploidy (n + 1) in Rb heterozygous females over chromosomally normal mice: 4.2% for Rb(X.2)2Ad/+; 2.1% for Rb(X.9)6H/+; 2.2% for Rb(X.12)7H/+ and 1.1% for normal females [4].
Intercrosses of heterozygous females and hemizygous males yielded 5.5% aneuploidy for Rb(X.2)2Ad and 5.4% for Rb(X.9)6H [4].

Biological context of Rb(X.2)2Ad

The influence of these new Rbs on meiotic chromosome segregation was investigated in hemizygous males and heterozygous females and compared to that of Rb(X.2)2Ad [4].
Spontaneously cycling LT/Sv strain female mice were mated to hemizygous Rb(X.2)2Ad males in order to facilitate the distinction of the paternal X chromosome, and the pregnant females were autopsied at about midday on the tenth day of gestation [5].
The influence of the Robertsonian translocation Rb(X.2)2Ad on anaphase I non-disjunction in male laboratory mice [6].
In breeding tests, 5% of the progeny of Rb(X.2)2Ad/Y males were sex chromosome aneuploids compared to 10% of the Rb(X.9)6H/Y offspring [4].

References

Two new X-autosome Robertsonian translocations in the mouse. II. Sex chromosome configurations in spermatocytes of hemizygous males. Tease, C., Fisher, G. Chromosoma (1993) [Pubmed]
Parental imprinting on the mouse X chromosome: effects on the early development of X0, XXY and XXX embryos. Tada, T., Takagi, N., Adler, I.D. Genet. Res. (1993) [Pubmed]
The differential staining pattern of the X chromosome in the embryonic and extraembryonic tissues of postimplantation homozygous tetraploid mouse embryos. Webb, S., de Vries, T.J., Kaufman, M.H. Genet. Res. (1992) [Pubmed]
Two new X-autosome Robertsonian translocations in the mouse. I. Meiotic chromosome segregation in male hemizygotes and female heterozygotes. Tease, C., Fisher, G. Genet. Res. (1991) [Pubmed]
The pattern of X-chromosome inactivation in the embryonic and extra-embryonic tissues of post-implantation digynic triploid LT/Sv strain mouse embryos. Speirs, S., Cross, J.M., Kaufman, M.H. Genet. Res. (1990) [Pubmed]
The influence of the Robertsonian translocation Rb(X.2)2Ad on anaphase I non-disjunction in male laboratory mice. Adler, I.D., Johannisson, R., Winking, H. Genet. Res. (1989) [Pubmed]

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