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EIF4EBP2  -  eukaryotic translation initiation factor...

Homo sapiens

Synonyms: 4E-BP2, 4EBP2, Eukaryotic translation initiation factor 4E-binding protein 2, PHASII, eIF4E-binding protein 2
 
 
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Disease relevance of EIF4EBP2

  • Here we show that early in adenovirus infection, 4E-BP1 and its related protein 4E-BP2 are phosphorylated and hence inactivated [1].
 

High impact information on EIF4EBP2

 

Biological context of EIF4EBP2

  • Phosphorylation of 4E-BP1 and 4E-BP2 is consistent with earlier findings in adenovirus-infected cells on the activation of the protein kinase p70(S6k), whose phosphorylation lies on the same pathway as 4E-BPs, by E1A [1].
  • This indicates that 4E-BP1 down-regulation is associated with granulocytic maturation, whereas post-transcriptional regulation of 4E-BP2 expression is associated with the early action of RA [6].
 

Anatomical context of EIF4EBP2

  • In this study, we further investigated the regulation of 4E-BP1 and 4E-BP2 in the RA-induced differentiation process using the NB4 promyelocytic cell line and the RA maturation-resistant NB4 subclones, NB4-R1 and NB4-R2 [6].
 

Associations of EIF4EBP2 with chemical compounds

  • RA treatment resulted in a decrease in 4E-BP1 protein and mRNA expression and concomitant increase in 4E-BP2 protein expression, in NB4 cells, but not in NB4-R1 and NB4-R2 cells [6].
 

Other interactions of EIF4EBP2

  • 4E-BP3 is homologous to 4E-BP1 and 4E-BP2, exhibiting 57 and 59% identity, respectively [7].
 

Analytical, diagnostic and therapeutic context of EIF4EBP2

References

  1. Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2. Gingras, A.C., Sonenberg, N. Virology (1997) [Pubmed]
  2. A link between protein translation and body weight. Rui, L. J. Clin. Invest. (2007) [Pubmed]
  3. Differential regulation of 4E-BP1 and 4E-BP2, two repressors of translation initiation, during human myeloid cell differentiation. Grolleau, A., Sonenberg, N., Wietzerbin, J., Beretta, L. J. Immunol. (1999) [Pubmed]
  4. Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2. Tsukiyama-Kohara, K., Vidal, S.M., Gingras, A.C., Glover, T.W., Hanash, S.M., Heng, H., Sonenberg, N. Genomics (1996) [Pubmed]
  5. Binding analysis of Xenopus laevis translation initiation factor 4E (eIF4E) in initiation complex formation. Miyoshi, H., Youtani, T., Ide, H., Hori, H., Okamoto, K., Ishikawa, M., Wakiyama, M., Nishino, T., Ishida, T., Miura, K. J. Biochem. (1999) [Pubmed]
  6. Defect in the regulation of 4E-BP1 and 2, two repressors of translation initiation, in the retinoid acid resistant cell lines, NB4-R1 and NB4-R2. Grolleau, A., Wietzerbin, J., Beretta, L. Leukemia (2000) [Pubmed]
  7. 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. Poulin, F., Gingras, A.C., Olsen, H., Chevalier, S., Sonenberg, N. J. Biol. Chem. (1998) [Pubmed]
 
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