Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Trim30a - tripartite motif-containing 30A

Mus musculus

Synonyms: Down regulatory protein of interleukin-2 receptor, Rpt-1, Rpt1, Trim30, Tripartite motif-containing protein 30, ...

Patarca, R. et al., Tissot, C. et al., Patarca, R. et al.

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Disease relevance of Trim30

We suggest that altered expression of Rpt-1 may be associated with HTLV-I-dependent T-cell leukemias [1].

High impact information on Trim30

In the course of these studies we have isolated a human cDNA which codes for a protein sharing homology with the mouse Rpt-1 gene; it will be referred as Staf-50 for Stimulated Trans-Acting Factor of 50 kDa [2].
Definition of T-cell specific DNA-binding factors that interact with a 3'-silencer in the CD4+ T-cell gene Rpt-1 [3].
Analysis of the region 3' to the CD4+ T-cell gene Rpt-1 (encoding regulatory protein T-lymphocyte 1) led to the definition of a silencer element that inhibits heterologous gene expression in certain CD4+ T-cell lines but not in B-cell or non-lymphoid cell lines [3].

References

Structural features of two T-cell-specific genes that suggest a potential role in HTLV-I-associated pathology. Patarca, R., Fletcher, M.A., Cantor, H. AIDS Res. Hum. Retroviruses (1993) [Pubmed]
Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression. Tissot, C., Mechti, N. J. Biol. Chem. (1995) [Pubmed]
Definition of T-cell specific DNA-binding factors that interact with a 3'-silencer in the CD4+ T-cell gene Rpt-1. Patarca, R., Singh, R.P., Durfee, T., Freeman, G., Blattner, F.R., Cantor, H. Gene (1989) [Pubmed]

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