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Gene Review

UNC13D  -  unc-13 homolog D (C. elegans)

Homo sapiens

Synonyms: FHL3, HLH3, HPLH3, Munc13-4, Protein unc-13 homolog D
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Disease relevance of UNC13D


High impact information on UNC13D


Associations of UNC13D with chemical compounds


Biological context of UNC13D


Anatomical context of UNC13D


Other interactions of UNC13D

  • Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets [9].
  • We analyzed a large group of 63 unrelated patients with FHL of different geographic origins (Turkey:32; Germany:23; others:8) for mutations in STX11, PRF1, and UNC13D [8].
  • We identified mutations in 38 samples (20 in PRF1, 12 in UNC13D, and six in STX11) [8].
  • Furthermore, we affinity-purified a GTP-Rab27A-binding protein in platelets and identified it as Munc13-4, a homologue of Munc13-1 known as a priming factor for neurotransmitter release [9].
  • Thus, FHL-2, FHL-3, and FHL-4 account for 80% of the HLH cases of Turkish origin, and for 30% of German patients [8].

Analytical, diagnostic and therapeutic context of UNC13D

  • The immunoprecipitation experiments suggest that in the presence of excessive Munc13-4 and SLP-5 proteins, Rab27a interaction with ENaC is diminished [12].


  1. Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3). Feldmann, J., Callebaut, I., Raposo, G., Certain, S., Bacq, D., Dumont, C., Lambert, N., Ouachée-Chardin, M., Chedeville, G., Tamary, H., Minard-Colin, V., Vilmer, E., Blanche, S., Le Deist, F., Fischer, A., de Saint Basile, G. Cell (2003) [Pubmed]
  2. Novel Munc13-4 mutations in children and young adult patients with haemophagocytic lymphohistiocytosis. Santoro, A., Cannella, S., Bossi, G., Gallo, F., Trizzino, A., Pende, D., Dieli, F., Bruno, G., Stinchcombe, J.C., Micalizzi, C., De Fusco, C., Danesino, C., Moretta, L., Notarangelo, L.D., Griffiths, G.M., Aric??, M. J. Med. Genet. (2006) [Pubmed]
  3. Rab27a negatively regulates CFTR chloride channel function in colonic epithelia: involvement of the effector proteins in the regulatory mechanism. Saxena, S.K., Kaur, S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  4. Getting secretory granules ready for prime time. Zhang, B., Ginsburg, D. Cell (2003) [Pubmed]
  5. Cytotoxic T lymphocyte exocytosis: bring on the SNAREs! Hong, W. Trends Cell Biol. (2005) [Pubmed]
  6. Analysis of natural killer-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease. Marcenaro, S., Gallo, F., Martini, S., Santoro, A., Griffiths, G.M., Aricó, M., Moretta, L., Pende, D. Blood (2006) [Pubmed]
  7. Munc13-4 regulates granule secretion in human neutrophils. Pivot-Pajot, C., Varoqueaux, F., de Saint Basile, G., Bourgoin, S.G. J. Immunol. (2008) [Pubmed]
  8. Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A. Zur Stadt, U., Beutel, K., Kolberg, S., Schneppenheim, R., Kabisch, H., Janka, G., Hennies, H.C. Hum. Mutat. (2006) [Pubmed]
  9. Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets. Shirakawa, R., Higashi, T., Tabuchi, A., Yoshioka, A., Nishioka, H., Fukuda, M., Kita, T., Horiuchi, H. J. Biol. Chem. (2004) [Pubmed]
  10. Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11. zur Stadt, U., Schmidt, S., Kasper, B., Beutel, K., Diler, A.S., Henter, J.I., Kabisch, H., Schneppenheim, R., Nürnberg, P., Janka, G., Hennies, H.C. Hum. Mol. Genet. (2005) [Pubmed]
  11. Purification and functional analysis of a Rab27 effector munc 13-4 using a semi-intact platelet dense-granule secretion assay. Shirakawa, R., Higashi, T., Kondo, H., Yoshioka, A., Kita, T., Horiuchi, H. Meth. Enzymol. (2005) [Pubmed]
  12. Rab27a regulates epithelial sodium channel (ENaC) activity through synaptotagmin-like protein (SLP-5) and Munc13-4 effector mechanism. Saxena, S.K., Horiuchi, H., Fukuda, M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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