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Gene Review

KHDRBS2  -  KH domain containing, RNA binding, signal...

Homo sapiens

Synonyms: KH domain-containing, RNA-binding, signal transduction-associated protein 2, MGC26664, SLM-1, SLM1, Sam68-like mammalian protein 1, ...
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High impact information on KHDRBS2

  • Together, our data suggest that Slm1 and Slm2 define a molecular link between phosphoinositide and sphingolipid signaling and thereby regulate actin cytoskeleton organization [1].
  • Furthermore, a mutant SLM1 protein (SLM1(DeltaC14)) lacking a sequence related to the consensus calcineurin docking site (PxIxIT) was insensitive to calcineurin, and SLM1(Delta)(C14) slm2 mutant cells were hypersensitive to oxidative stress [2].
  • We compared the sound speeds of SLM-1/UV (990 M/sec at 35 degrees Celsius [degrees C]), SLM-2/UV (1090 M/sec at 35 degrees C), and Perspex CQ poly(methyl methacrylate)(2658 M/sec at 35 degrees C) [3].
  • A major suppressor of cell death, slm1, modifies the expression of the maize (Zea mays L.) lesion mimic mutation les23 [4].
  • KHDRBS2 has the characteristic Sam68 SH2 and SH3 domain binding sites [5].

Associations of KHDRBS2 with chemical compounds

  • The characterization of KHDRBS2 indicates it may link tyrosine kinase signaling cascades with some aspect of RNA metabolism [5].
  • The purpose of this study was to investigate the apparent viscosities and mechanical properties of two experimental light-curing soft lining materials (SLM-1 and SLM-2) based on soft-type urethane oligomers, as well as the shear bond strength and dye penetration between the denture base resin and the polymerized SLMs after storage in water [6].

Analytical, diagnostic and therapeutic context of KHDRBS2

  • Methods are presented to determine the correction of axial length (CAL) factors for axial length measurements made on pseudophakes with AMO PhacoFlex Si-18, Si-26 (SLM-1/UV), and AMO PhacoFlex II SI-20 or SI-30 (SLM-2/UV) silicone intraocular lenses (IOLs) [3].


  1. The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Tabuchi, M., Audhya, A., Parsons, A.B., Boone, C., Emr, S.D. Mol. Cell. Biol. (2006) [Pubmed]
  2. Mutual antagonism of target of rapamycin and calcineurin signaling. Mulet, J.M., Martin, D.E., Loewith, R., Hall, M.N. J. Biol. Chem. (2006) [Pubmed]
  3. Effect of silicone sound speed and intraocular lens thickness on pseudophakic axial length corrections. Yang, S., Lang, A., Makker, H., Zaleski, E. Journal of cataract and refractive surgery. (1995) [Pubmed]
  4. A major suppressor of cell death, slm1, modifies the expression of the maize (Zea mays L.) lesion mimic mutation les23. Penning, B.W., Johal, G.S., McMullen, M.D. Genome (2004) [Pubmed]
  5. Cloning and characterization of a novel human STAR domain containing cDNA KHDRBS2. Wang, L., Xu, J., Zeng, L., Ye, X., Wu, Q., Dai, J., Ji, C., Gu, S., Zhao, C., Xie, Y., Mao, Y. Mol. Biol. Rep. (2002) [Pubmed]
  6. Mechanical properties of an experimental soft lining material based on urethane oligomer. Kanie, T., Kadokawa, A., Arikawa, H., Fujii, K., Ban, S. Dental materials journal. (2005) [Pubmed]
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