Disease relevance of KHDRBS3

• Sam68-like mammalian protein 2, identified by digital differential display as expressed by podocytes, is induced in proteinuria and involved in splice site selection of vascular endothelial growth factor [1].
• Expression of T-STAR gene is associated with regulation of telomerase activity in human colon cancer cell line HCT-116 [2].
• There are no signs of metabolic bone disease or hepatopathy corresponding with the increased SALP, nor is there a disease common to all children with THI [3].

High impact information on KHDRBS3

• SLM1 had extensive sequence similarity to the snapdragon MADS box gene PLENA, SLM2 to GLOBOSA, SLM3 to DEFICIENS, and both SLM4 and SLM5 were similar to SQUAMOSA [4].
• Together, our data suggest that Slm1 and Slm2 define a molecular link between phosphoinositide and sphingolipid signaling and thereby regulate actin cytoskeleton organization [5].
• T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis [6].
• Furthermore, a mutant SLM1 protein (SLM1(DeltaC14)) lacking a sequence related to the consensus calcineurin docking site (PxIxIT) was insensitive to calcineurin, and SLM1(Delta)(C14) slm2 mutant cells were hypersensitive to oxidative stress [7].
• SLM-2-dependent VEGF splicing indicates the importance of mRNA splice site selection for glomerular filtration barrier function [1].

Biological context of KHDRBS3

• Comparison of brain and kidney cDNA libraries with those of other organs identified Sam68-like mammalian protein 2 (SLM-2), a member of the STAR family of RNA processing proteins, as expressed by podocytes [1].
• T-STAR is located within the markers D8S2049 and D8S1753 and its complete coding region spans nine exons [8].
• T-STAR is a novel member of STAR (for signal transduction and activation of RNA) family, and is predicted to encode a spermatogenesis related RNA-binding protein [8].
• Oral Al bioavailability was then determined from a biscuit containing 1% or 2% acidic SALP, synthesized to contain (26)Al [9].
• AIM: To investigate the effects on telomerase activity of transfection of human T-STAR gene full-length sense cDNA or partial antisense cDNA into human colon cancer cell line HCT-116 [2].

Anatomical context of KHDRBS3

• Knockdown of SLM-2 by short interfering RNA in podocytes was performed to evaluate its biologic role [1].
• In addition to its known expression in testis, moderate level of transcripts for T-STAR gene was detected in brain, heart and is highly abundant in skeletal muscle [8].
• Similar pathways likely operate in germ cells and somatic cells, with RBMY, hnRNPGT and T-STAR proteins providing germ cell-specific components [10].
• CONCLUSION: The T-STAR gene may participate in regulation of telomerase activity in human colon cancer HCT-116 cells in a parallel fashion [2].
• Vibration of the dorsal neck muscles in man induces falling reactions, walking and "marche en étoile", probably by muscle afferent activation [11].

Associations of KHDRBS3 with chemical compounds

• The purpose of this study was to investigate the apparent viscosities and mechanical properties of two experimental light-curing soft lining materials (SLM-1 and SLM-2) based on soft-type urethane oligomers, as well as the shear bond strength and dye penetration between the denture base resin and the polymerized SLMs after storage in water [12].
• The aim of the present study was to evaluate the accuracy of the new VITEK 2 system (bioMérieux, Marcy l' Etoile, France) for the detection of methicillin resistance in coagulase-negative staphylococci (CoNS) by using AST-P515 and AST-P523 test cards [13].
• METHODS: Six IOL materials were analyzed: standard poly(methyl methacrylate) (PMMA), heparin-surface-modified (HSM) PMMA, AcrySof, 2 polyHEMAs with different water contents, and a second-generation SLM-2 silicone [14].
• When administered in combination with cisplatin (DDP), SALP INX-6295 produced a complete tumor regression in approximately 30% of treated mice, which persisted for at least 60 days following the first cycle of treatment [15].
• Intraperitoneal administration of CCl(4) (2ml/kg) to rats for 4 days resulted in significantly elevated (p<0.05) serum levels of glutamic oxaloacetic transaminase (SGOT), glutamic pyruvate transaminase (SGPT) and alkaline phosphatase (SALP) compared to controls [16].

Other interactions of KHDRBS3

• In the present communication, we show that T-STAR gene is located within the ECA1 region [8].
• T-STAR gene: fine mapping in the candidate region for childhood absence epilepsy on 8q24 and mutational analysis in patients [8].

Analytical, diagnostic and therapeutic context of KHDRBS3

• Methods are presented to determine the correction of axial length (CAL) factors for axial length measurements made on pseudophakes with AMO PhacoFlex Si-18, Si-26 (SLM-1/UV), and AMO PhacoFlex II SI-20 or SI-30 (SLM-2/UV) silicone intraocular lenses (IOLs) [17].
• Expression of the B-function gene SLM2, an ortholog of PISTILLATA (PI) in Arabidopsis, was examined by in situ hybridization [18].
• METHODS: mRNA and protein expression levels of T-STAR gene were determined by RT-PCR and western blot, and telomerase activity was measured by PCR-ELISA, after transfection of T-STAR sense or antisense gene into HCT-116 cells with lipofectamine [2].

References