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Gene Review

KHDRBS3  -  KH domain containing, RNA binding, signal...

Homo sapiens

Synonyms: Etle, KH domain-containing, RNA-binding, signal transduction-associated protein 3, RNA-binding protein T-Star, SALP, SLM-2, ...
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Disease relevance of KHDRBS3


High impact information on KHDRBS3

  • SLM1 had extensive sequence similarity to the snapdragon MADS box gene PLENA, SLM2 to GLOBOSA, SLM3 to DEFICIENS, and both SLM4 and SLM5 were similar to SQUAMOSA [4].
  • Together, our data suggest that Slm1 and Slm2 define a molecular link between phosphoinositide and sphingolipid signaling and thereby regulate actin cytoskeleton organization [5].
  • T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis [6].
  • Furthermore, a mutant SLM1 protein (SLM1(DeltaC14)) lacking a sequence related to the consensus calcineurin docking site (PxIxIT) was insensitive to calcineurin, and SLM1(Delta)(C14) slm2 mutant cells were hypersensitive to oxidative stress [7].
  • SLM-2-dependent VEGF splicing indicates the importance of mRNA splice site selection for glomerular filtration barrier function [1].

Biological context of KHDRBS3


Anatomical context of KHDRBS3

  • Knockdown of SLM-2 by short interfering RNA in podocytes was performed to evaluate its biologic role [1].
  • In addition to its known expression in testis, moderate level of transcripts for T-STAR gene was detected in brain, heart and is highly abundant in skeletal muscle [8].
  • Similar pathways likely operate in germ cells and somatic cells, with RBMY, hnRNPGT and T-STAR proteins providing germ cell-specific components [10].
  • CONCLUSION: The T-STAR gene may participate in regulation of telomerase activity in human colon cancer HCT-116 cells in a parallel fashion [2].
  • Vibration of the dorsal neck muscles in man induces falling reactions, walking and "marche en étoile", probably by muscle afferent activation [11].

Associations of KHDRBS3 with chemical compounds

  • The purpose of this study was to investigate the apparent viscosities and mechanical properties of two experimental light-curing soft lining materials (SLM-1 and SLM-2) based on soft-type urethane oligomers, as well as the shear bond strength and dye penetration between the denture base resin and the polymerized SLMs after storage in water [12].
  • The aim of the present study was to evaluate the accuracy of the new VITEK 2 system (bioMérieux, Marcy l' Etoile, France) for the detection of methicillin resistance in coagulase-negative staphylococci (CoNS) by using AST-P515 and AST-P523 test cards [13].
  • METHODS: Six IOL materials were analyzed: standard poly(methyl methacrylate) (PMMA), heparin-surface-modified (HSM) PMMA, AcrySof, 2 polyHEMAs with different water contents, and a second-generation SLM-2 silicone [14].
  • When administered in combination with cisplatin (DDP), SALP INX-6295 produced a complete tumor regression in approximately 30% of treated mice, which persisted for at least 60 days following the first cycle of treatment [15].
  • Intraperitoneal administration of CCl(4) (2ml/kg) to rats for 4 days resulted in significantly elevated (p<0.05) serum levels of glutamic oxaloacetic transaminase (SGOT), glutamic pyruvate transaminase (SGPT) and alkaline phosphatase (SALP) compared to controls [16].

Other interactions of KHDRBS3

  • In the present communication, we show that T-STAR gene is located within the ECA1 region [8].
  • T-STAR gene: fine mapping in the candidate region for childhood absence epilepsy on 8q24 and mutational analysis in patients [8].

Analytical, diagnostic and therapeutic context of KHDRBS3


  1. Sam68-like mammalian protein 2, identified by digital differential display as expressed by podocytes, is induced in proteinuria and involved in splice site selection of vascular endothelial growth factor. Cohen, C.D., Doran, P.P., Blattner, S.M., Merkle, M., Wang, G.Q., Schmid, H., Mathieson, P.W., Saleem, M.A., Henger, A., Rastaldi, M.P., Kretzler, M. J. Am. Soc. Nephrol. (2005) [Pubmed]
  2. Expression of T-STAR gene is associated with regulation of telomerase activity in human colon cancer cell line HCT-116. Zhang, L., Guo, L., Peng, Y., Chen, B. World J. Gastroenterol. (2006) [Pubmed]
  3. Transient hyperphosphatasemia--where do we stand? Kutílek, S., Bayer, M. Turk. J. Pediatr. (1999) [Pubmed]
  4. Comparison of MADS box gene expression in developing male and female flowers of the dioecious plant white campion. Hardenack, S., Ye, D., Saedler, H., Grant, S. Plant Cell (1994) [Pubmed]
  5. The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Tabuchi, M., Audhya, A., Parsons, A.B., Boone, C., Emr, S.D. Mol. Cell. Biol. (2006) [Pubmed]
  6. T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis. Venables, J.P., Vernet, C., Chew, S.L., Elliott, D.J., Cowmeadow, R.B., Wu, J., Cooke, H.J., Artzt, K., Eperon, I.C. Hum. Mol. Genet. (1999) [Pubmed]
  7. Mutual antagonism of target of rapamycin and calcineurin signaling. Mulet, J.M., Martin, D.E., Loewith, R., Hall, M.N. J. Biol. Chem. (2006) [Pubmed]
  8. T-STAR gene: fine mapping in the candidate region for childhood absence epilepsy on 8q24 and mutational analysis in patients. Sugimoto, Y., Morita, R., Amano, K., Shah, P.U., Pascual-Castroviejo, I., Khan, S., Delgado-Escueta, A.V., Yamakawa, K. Epilepsy Res. (2001) [Pubmed]
  9. Aluminum bioavailability from the approved food additive leavening agent acidic sodium aluminum phosphate, incorporated into a baked good, is lower than from water. Yokel, R.A., Florence, R.L. Toxicology (2006) [Pubmed]
  10. The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis. Elliott, D.J. Int. J. Androl. (2004) [Pubmed]
  11. Postural effects of neck muscle vibration in man. Lund, S. Experientia (1980) [Pubmed]
  12. Mechanical properties of an experimental soft lining material based on urethane oligomer. Kanie, T., Kadokawa, A., Arikawa, H., Fujii, K., Ban, S. Dental materials journal. (2005) [Pubmed]
  13. Rapid detection of methicillin resistance in coagulase-negative Staphylococci with the VITEK 2 system. Horstkotte, M.A., Knobloch, J.K., Rohde, H., Dobinsky, S., Mack, D. J. Clin. Microbiol. (2002) [Pubmed]
  14. Solvent for removing silicone oil from intraocular lenses: experimental study comparing various biomaterials. Dick, H.B., Augustin, A.J. Journal of cataract and refractive surgery. (2000) [Pubmed]
  15. Encapsulation of c-myc antisense oligodeoxynucleotides in lipid particles improves antitumoral efficacy in vivo in a human melanoma line. Leonetti, C., Biroccio, A., Benassi, B., Stringaro, A., Stoppacciaro, A., Semple, S.C., Zupi, G. Cancer Gene Ther. (2001) [Pubmed]
  16. Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl(4)-induced liver injury in rats. Jayakumar, T., Ramesh, E., Geraldine, P. Food Chem. Toxicol. (2006) [Pubmed]
  17. Effect of silicone sound speed and intraocular lens thickness on pseudophakic axial length corrections. Yang, S., Lang, A., Makker, H., Zaleski, E. Journal of cataract and refractive surgery. (1995) [Pubmed]
  18. Expression of the floral B-function gene SLM2 in female flowers of Silene latifolia infected with the smut fungus Microbotryum violaceum. Kazama, Y., Koizumi, A., Uchida, W., Ageez, A., Kawano, S. Plant Cell Physiol. (2005) [Pubmed]
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