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Gene Review

ENSA  -  endosulfine alpha

Homo sapiens

Synonyms: ARPP-19e, Alpha-endosulfine, MGC4319, MGC78563, MGC8394
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Disease relevance of ENSA


Psychiatry related information on ENSA


High impact information on ENSA


Biological context of ENSA


Anatomical context of ENSA

  • In addition, we did not detect any significant correlation of skeletal muscle ENSA transcript levels with differences in insulin action in 49 non-diabetic subjects [5].

Associations of ENSA with chemical compounds

  • We conclude that sequence alterations in ENSA are an unlikely cause for the linkage of T2DM with 1q21-q23 in the Pima Indians [5].
  • Although K(ATP) channels are also present in brain and its regulators have been reported to be involved in the release of neurotransmitters such as acetylcholine that plays an important role in cognitive function, the neurobiological role of alpha-endosulfine has not been studied yet [1].


  1. Decreased alpha-endosulfine, an endogenous regulator of ATP-sensitive potassium channels, in brains from adult Down syndrome patients. Kim, S.H., Lubec, G. J. Neural Transm. Suppl. (2001) [Pubmed]
  2. Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties. Heron, L., Virsolvy, A., Peyrollier, K., Gribble, F.M., Le Cam, A., Ashcroft, F.M., Bataille, D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels. Héron, L., Virsolvy, A., Apiou, F., Le Cam, A., Bataille, D. Diabetes (1999) [Pubmed]
  4. Alpha-endosulfine, a positional and functional candidate gene for type 2 diabetes: molecular screening, association studies, and role in reduced insulin secretion. Wang, H., Craig, R.L., Schay, J., Chu, W., Das, S.K., Zhang, Z., Elbein, S.C. Mol. Genet. Metab. (2004) [Pubmed]
  5. The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians. Thameem, F., Farook, V.S., Yang, X., Lee, Y.H., Permana, P.A., Bogardus, C., Prochazka, M. Mol. Genet. Metab. (2004) [Pubmed]
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