Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

ENSA - endosulfine alpha

Homo sapiens

Synonyms: ARPP-19e, Alpha-endosulfine, MGC4319, MGC78563, MGC8394

Kim, S.H. et al., Thameem, F. et al., Héron, L. et al., Wang, H. et al., Heron, L. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ENSA

Decreased alpha-endosulfine, an endogenous regulator of ATP-sensitive potassium channels, in brains from adult Down syndrome patients [1].

Psychiatry related information on ENSA

We examined the expression levels of alpha-endosulfine protein in frontal cortex and cerebellum from patients with Down syndrome (DS) showing Alzheimer's disease (AD) pathology using Western blotting [1].

High impact information on ENSA

Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties [2].
The ENSA gene appears to be a 1.8-kb-long sequence that contains the transcription initiation site located 528 bp upstream of the initiation codon [3].
The ENSA gene is intronless, and a single copy gene seems to be present in the genome [3].
The recombinant alpha-endosulfine inhibits sulfonylurea binding to beta-cell membranes, reduces cloned K(ATP) channel currents, and stimulates insulin secretion from beta-cells [3].
We mapped ENSA in silico to chromosome 1q21 near a confirmed type 2 diabetes susceptibility locus, and derived the genomic structure of four exons and three introns [4].

Biological context of ENSA

We analyzed ENSA in this Native American population and identified seven variants, which fall into three linkage disequilibrium groups [5].

Anatomical context of ENSA

In addition, we did not detect any significant correlation of skeletal muscle ENSA transcript levels with differences in insulin action in 49 non-diabetic subjects [5].

Associations of ENSA with chemical compounds

We conclude that sequence alterations in ENSA are an unlikely cause for the linkage of T2DM with 1q21-q23 in the Pima Indians [5].
Although K(ATP) channels are also present in brain and its regulators have been reported to be involved in the release of neurotransmitters such as acetylcholine that plays an important role in cognitive function, the neurobiological role of alpha-endosulfine has not been studied yet [1].

References

Decreased alpha-endosulfine, an endogenous regulator of ATP-sensitive potassium channels, in brains from adult Down syndrome patients. Kim, S.H., Lubec, G. J. Neural Transm. Suppl. (2001) [Pubmed]
Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties. Heron, L., Virsolvy, A., Peyrollier, K., Gribble, F.M., Le Cam, A., Ashcroft, F.M., Bataille, D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels. Héron, L., Virsolvy, A., Apiou, F., Le Cam, A., Bataille, D. Diabetes (1999) [Pubmed]
Alpha-endosulfine, a positional and functional candidate gene for type 2 diabetes: molecular screening, association studies, and role in reduced insulin secretion. Wang, H., Craig, R.L., Schay, J., Chu, W., Das, S.K., Zhang, Z., Elbein, S.C. Mol. Genet. Metab. (2004) [Pubmed]
The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians. Thameem, F., Farook, V.S., Yang, X., Lee, Y.H., Permana, P.A., Bogardus, C., Prochazka, M. Mol. Genet. Metab. (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

ENSA	Bos taurus
ENSA	Canis lupus familiaris
ensab	Danio rerio
ENSA	Gallus gallus
LOC715857	Macaca mulatta
Ensa	Mus musculus
ENSA	Pan troglodytes
Ensa	Rattus norvegicus
ensa	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.