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Gene Review:

Ensa - endosulfine alpha

Rattus norvegicus

Synonyms: ARPP-19e, Alpha-endosulfine

Biederman, J.I. et al., Yee, J. et al., Dulubova, I. et al., Peyrollier, K. et al., Dou, J. et al.

Yee, Cortes, Barnes, Alviani, Biederman, Szamosfalvi,

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High impact information on Ensa

BACKGROUND: Previously, we showed the expression of a unique sulfonylurea receptor (SUR) and its putative endogenous ligand, alpha-endosulfine, in mesangial cells and isolated glomeruli [1].
To investigate the possible role of alpha-endosulfine up-regulation in diabetes, we administered sulfonylureas, the exogenous ligands of SUR, to diabetic animals [1].
We postulate that mesangial alpha-endosulfine up-regulation in the hyperglycemic milieu of insulin-deficient diabetes may retard glomerular extracellular matrix formation and mesangial expansion [1].
This study investigates mesangial cell expression of ENSA, the gene encoding alpha-endosulfine, and its regulation by glucose [2].
A putative endogenous sulfonylurea, alpha-endosulfine, has been demonstrated in diverse tissues and is a member of the cyclic adenosine monophosphate (cAMP)-regulated family of phosphoproteins [2].

Biological context of Ensa

ARPP-19 is highly homologous to alpha-endosulfine and database searches allowed the identification of novel related proteins in D. melanogaster, C. elegans, S. mansoni and yeast genomes [3].
Gene expression of alpha-endosulfine in the rat brain: correlative changes with aging, learning and stress [4].

Analytical, diagnostic and therapeutic context of Ensa

Confocal microscopy revealed a diffusely granular, cytosolic distribution of alpha-endosulfine [2].
Expression of mesangial cell alpha-endosulfine was studied by immunoblotting, immunofluorescence, and confocal microscopy [2].
To determine whether the two proteins are different entities, we developed an RT-PCR strategy for analyzing the main portion of bovine alpha endosulfine [5].

References

Effects of sulfonylureas, alpha-endosulfine counterparts, on glomerulosclerosis in type 1 and type 2 models of diabetes. Biederman, J.I., Vera, E., Rankhaniya, R., Hassett, C., Giannico, G., Yee, J., Cortes, P. Kidney Int. (2005) [Pubmed]
Rat mesangial alpha-endosulfine. Yee, J., Cortes, P., Barnes, J.L., Alviani, R., Biederman, J.I., Szamosfalvi, B. Kidney Int. (2004) [Pubmed]
ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins. Dulubova, I., Horiuchi, A., Snyder, G.L., Girault, J.A., Czernik, A.J., Shao, L., Ramabhadran, R., Greengard, P., Nairn, A.C. J. Neurochem. (2001) [Pubmed]
Gene expression of alpha-endosulfine in the rat brain: correlative changes with aging, learning and stress. Dou, J., Cui, C., Dufour, F., Alkon, D.L., Zhao, W.Q. J. Neurochem. (2003) [Pubmed]
Alpha endosulfine is a novel molecule, structurally related to a family of phosphoproteins. Peyrollier, K., Héron, L., Virsolvy-Vergine, A., Le Cam, A., Bataille, D. Biochem. Biophys. Res. Commun. (1996) [Pubmed]

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ENSA	Bos taurus
ENSA	Canis lupus familiaris
ensab	Danio rerio
ENSA	Gallus gallus
ENSA	Homo sapiens
LOC715857	Macaca mulatta
Ensa	Mus musculus
ENSA	Pan troglodytes
ensa	Xenopus (Silurana) tropicalis

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