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Gene Review

EPHA7  -  EPH receptor A7

Homo sapiens

Synonyms: EHK-3, EHK3, EK11, EPH homology kinase 3, EPH-like kinase 11, ...
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Disease relevance of EPHA7


High impact information on EPHA7

  • This population was found to harbor transcripts of the Hek8 and Hek11 members of this gene family [2].
  • The developmentally regulated expression of Hek11 during fetal B lymphopoiesis suggests a role for this gene in pre/pro-B cell expansion and/or differentiation and defines a difference in progenitor B cell populations isolated from fetal versus adult human bone marrow [2].
  • In contrast, the Hek11 transcript was exclusively found in fetal bone marrow pro-B cells and pre-B cells, but not in more mature fetal B-lineage cells [2].
  • All adult B-lineage cells, from early pro-B cells to end-stage plasma cells, lacked Hek11 transcripts [2].
  • Because five TCF/LEF-binding sites were identified within the 5'-promoter region of the EPHA7 gene, comparative genomics analyses on EPHA7 orthologs were further performed [1].

Biological context of EPHA7


Regulatory relationships of EPHA7

  • Expression analysis of these genes in prostate cancer specimens showed CA1 to be highly expressed in bone metastasis but not expressed in primary tumor and EPHA7 to be expressed in normal prostate and primary tumor but not bone metastasis [3].


  1. Comparative integromics on Eph family. Katoh, M., Katoh, M. Int. J. Oncol. (2006) [Pubmed]
  2. Regulated expression of the Eph-related receptor tyrosine kinase Hek11 in early human B lymphopoiesis. Aasheim, H.C., Terstappen, L.W., Logtenberg, T. Blood (1997) [Pubmed]
  3. Application of Affymetrix array and Massively Parallel Signature Sequencing for identification of genes involved in prostate cancer progression. Oudes, A.J., Roach, J.C., Walashek, L.S., Eichner, L.J., True, L.D., Vessella, R.L., Liu, A.Y. BMC Cancer (2005) [Pubmed]
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