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Gene Review

EPHB1  -  EPH receptor B1

Homo sapiens

Synonyms: EK6, ELK, EPH tyrosine kinase 2, EPH-like kinase 6, EPHT2, ...
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High impact information on EPHB1

  • Many of these genes are involved in various cancers, including GASC1, shown previously to be amplified in ESCCs, and EPHB1 and PIK3C3 [1].
  • Most interestingly, the plasma membrane insertion of the WT-hNET and hNET double mutant were not affected by beta-PMA [2].
  • In addition, the PKC-induced phosphorylation of hNET double mutant was significantly reduced [2].
  • In the absence of T258A and S259A mutations, alanine substitution of all other potential phosphosites within the hNET did not block PKC-induced phosphorylation and down-regulation [2].
  • Although the WT-hNET showed increased endocytosis and redistribution from caveolin-rich plasma membrane domains following beta-PMA treatment, the hNET double mutant was completely resistant to these PKC-mediated effects [2].

Biological context of EPHB1

  • Individual genetic variations in the gene encoding the human NET (hNET), located at chromosome 16q12.2, may contribute to the pathogenesis of those diseases [3].

Anatomical context of EPHB1


Associations of EPHB1 with chemical compounds

  • Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma [4].

Other interactions of EPHB1

  • BACKGROUND: The EPH family is the largest subfamily of receptor protein-tyrosine kinases, consisting of EPHA and EPHB subgroups [6].


  1. Genome-wide association study in esophageal cancer using GeneChip mapping 10K array. Hu, N., Wang, C., Hu, Y., Yang, H.H., Giffen, C., Tang, Z.Z., Han, X.Y., Goldstein, A.M., Emmert-Buck, M.R., Buetow, K.H., Taylor, P.R., Lee, M.P. Cancer Res. (2005) [Pubmed]
  2. Phosphorylation of the norepinephrine transporter at threonine 258 and serine 259 is linked to protein kinase C-mediated transporter internalization. Jayanthi, L.D., Annamalai, B., Samuvel, D.J., Gether, U., Ramamoorthy, S. J. Biol. Chem. (2006) [Pubmed]
  3. The norepinephrine transporter in physiology and disease. Bönisch, H., Brüss, M. Handbook of experimental pharmacology. (2006) [Pubmed]
  4. Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma. Tang, X.X., Brodeur, G.M., Campling, B.G., Ikegaki, N. Clin. Cancer Res. (1999) [Pubmed]
  5. EPHB receptor signaling in dendritic spine development. Irie, F., Yamaguchi, Y. Front. Biosci. (2004) [Pubmed]
  6. Association among EPHB2, TrkA, and MYCN expression in low-stage neuroblastomas. Tang, X.X., Evans, A.E., Zhao, H., Cnaan, A., Brodeur, G.M., Ikegaki, N. Med. Pediatr. Oncol. (2001) [Pubmed]
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