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Gene Review

EPHA1  -  EPH receptor A1

Homo sapiens

Synonyms: EPH, EPH tyrosine kinase, EPH tyrosine kinase 1, EPHT, EPHT1, ...
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Disease relevance of EPHA1


High impact information on EPHA1

  • Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity [6].
  • The EPH-like receptor tyrosine kinase (RTK) HEK (human EPH-like kinase) was identified previously as a membrane antigen on the LK63 human pre-B-cell line and overexpression in leukemic specimens and cell lines suggested a role in oncogenesis [7].
  • HEK is a member of the EPH-like receptor tyrosine kinase family, which appear to have roles in development and oncogenesis [8].
  • The knowledge about intracellular pathways of signal transduction mediated by EPH-related receptors is still limited [9].
  • cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases [10].

Chemical compound and disease context of EPHA1


Biological context of EPHA1


Anatomical context of EPHA1

  • Shunt operations are preferred over direct operative procedures in patients with EPH when mesenteric veins suitable for shunting are available [3].
  • Studies were performed on normal umbilical cord arteries and those taken from newborns of mothers with EPH gestosis [4].
  • METHODS: Contact-inhibited human fibroblasts were incubated in Dulbecco culture medium containing control or EPH umbilical cord serum and supplemented with (14)C-glucosamine or (35)S-sulfate [5].
  • ET concentration in umbilical venous blood serum in 22 cases of EPH gestosis (group Gp) and 20 cases from the control group (Kp) was measured after delivery [19].
  • Different isoenzyme A patterns in homogenates were observed in placentas obtained from normal and prolonged pregnancies and in those complicated by EPH gestosis [20].

Associations of EPHA1 with chemical compounds

  • Genomic structure of the EPHA1 receptor tyrosine kinase gene [16].
  • EPH serum was much more active in stimulation of sulfated GAGs biosynthesis than control serum, whereas the biosynthesis of hyaluronic acid was stimulated by both sera to a similar degree [5].
  • A thermal gradient (temperature range 7-45 degrees C) was used to assess ambient temperature (Ta) preferences of rats following treatment with clonidine (25 microg/kg), norepinephrine (NE, 250 microg/kg), isoproterenol (ISO, 50 microg/kg), and ephedrine (EPH, 10 mg/kg) [21].
  • In contrast to the response of non-pregnant women, healthy pregnant women and women with EPH gestosis showed a significantly smaller increase in ANF secretion induced by WI [22].
  • The present study was undertaken in order to determine the changes in blood levels of lipid peroxide and vitamin E in EPH gestosis [23].

Other interactions of EPHA1

  • Ligands of EPH family receptors are called ephrins, which include ephrin-A and ephrin-B subgroups [24].
  • BACKGROUND: The EPH family is the largest subfamily of receptor protein-tyrosine kinases, consisting of EPHA and EPHB subgroups [24].
  • ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers [25].
  • According to Kaplan-Meier estimates, high EPHA1, and low SMAD1 and MARCO expression were associated with better progression-free survival (PFS) [26].

Analytical, diagnostic and therapeutic context of EPHA1

  • Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk [27].
  • Our findings demonstrate the application of biosensor technology in ligand purification and show that AL-1, as has been found for other ligands of the EPH-like RTK family, binds more than one receptor [7].
  • In this study we have used a more directed approach to identify new members of the EPH/elk-family by PCR of human embryonic cDNA: we utilized oligonucleotide primers specifically designed to a highly conserved N-terminal motif and the kinase region of EPH/elk-PTKs in RNA-PCRs [28].
  • For these mothers, the incidence of EPH gestosis on admission was 42.5%, in contrast to 31.4% for a control group matched for age, parity and nationality [29].
  • It is concluded that dependence on overeating in pregnancy may result in higher rates of EPH gestosis, cesarean section and perinatal mortality [30].


  1. Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. Bennett, B.D., Wang, Z., Kuang, W.J., Wang, A., Groopman, J.E., Goeddel, D.V., Scadden, D.T. J. Biol. Chem. (1994) [Pubmed]
  2. Genetics of hypertension in pregnancy: possible single gene control of pre-eclampsia and eclampsia in the descendants of eclamptic women. Chesley, L.C., Cooper, D.W. British journal of obstetrics and gynaecology. (1986) [Pubmed]
  3. Surgical management of portal hypertension in childhood: long-term results. Fonkalsrud, E.W. Archives of surgery (Chicago, Ill. : 1960) (1980) [Pubmed]
  4. Elastin of the umbilical cord arteries and its alterations in EPH gestosis (preeclampsia). Pawlicka, E., Bańkowski, E., Jaworski, S. Biol. Neonate (1999) [Pubmed]
  5. Stimulation of glycosaminoglycan biosynthesis by umbilical cord serum of newborns delivered by mothers with EPH gestosis (preeclampsia). Romanowicz, L., Bańkowski, E., Jaworski, S. Pathobiology (2000) [Pubmed]
  6. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Davis, S., Gale, N.W., Aldrich, T.H., Maisonpierre, P.C., Lhotak, V., Pawson, T., Goldfarb, M., Yancopoulos, G.D. Science (1994) [Pubmed]
  7. Purification of a ligand for the EPH-like receptor HEK using a biosensor-based affinity detection approach. Lackmann, M., Bucci, T., Mann, R.J., Kravets, L.A., Viney, E., Smith, F., Moritz, R.L., Carter, W., Simpson, R.J., Nicola, N.A., Mackwell, K., Nice, E.C., Wilks, A.F., Boyd, A.W. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  8. Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor. Lackmann, M., Mann, R.J., Kravets, L., Smith, F.M., Bucci, T.A., Maxwell, K.F., Howlett, G.J., Olsson, J.E., Vanden Bos, T., Cerretti, D.P., Boyd, A.W. J. Biol. Chem. (1997) [Pubmed]
  9. Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions. Hock, B., Böhme, B., Karn, T., Feller, S., Rübsamen-Waigmann, H., Strebhardt, K. Oncogene (1998) [Pubmed]
  10. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. Fox, G.M., Holst, P.L., Chute, H.T., Lindberg, R.A., Janssen, A.M., Basu, R., Welcher, A.A. Oncogene (1995) [Pubmed]
  11. Platelet taurine concentration and uptake in gestosis patients with edema, proteinuria and hypertension. Otani, F., Ejiri, K., Kanemori, H., Kudo, T., Sekiba, K. Acta Med. Okayama (1992) [Pubmed]
  12. HPL and estriol serum levels of placental perfusion as indexes of placental function in EPH gestosis and placental insufficiency. Gitsch, E., Janisch, H., Spona, J. Gynecol. Obstet. Invest. (1980) [Pubmed]
  13. Recent aspects of hemostasis, hematology and hemorheology in preeclampsia-eclampsia. Graeff, H., von Hugo, R., Schröck, R. Eur. J. Obstet. Gynecol. Reprod. Biol. (1984) [Pubmed]
  14. Perinatal morbidity and mortality in pregnancy hypertensive disorders: prognostic value of the clinical and laboratory findings. Acién, P., Lloret, G., Lloret, M. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. (1990) [Pubmed]
  15. Primary aldosteronism caused by aldosterone-producing adenoma in pregnancy--complicated by EPH gestosis. Kreze, A., Kothaj, P., Dobáková, M., Rohon, S. Wien. Klin. Wochenschr. (1999) [Pubmed]
  16. Genomic structure of the EPHA1 receptor tyrosine kinase gene. Owshalimpur, D., Kelley, M.J. Mol. Cell. Probes (1999) [Pubmed]
  17. Comparative integromics on Eph family. Katoh, M., Katoh, M. Int. J. Oncol. (2006) [Pubmed]
  18. Maternal plasma concentrations of magnesium, calcium, zinc and copper in normal and pathological pregnancies. Borella, P., Szilagyi, A., Than, G., Csaba, I., Giardino, A., Facchinetti, F. Sci. Total Environ. (1990) [Pubmed]
  19. Serum level of endothelin-1 and -2 in pregnancies complicated by EPH gestosis. Leszczynska-Gorzelak, B., Kaminski, K., Szymula, D., Sawulicka-Oleszczuk, H., Oleszczuk, J. Gynecol. Obstet. Invest. (1997) [Pubmed]
  20. Isoenzymes of N-acetyl-beta-hexosaminidase in complicated pregnancy. Arciuch, L.P., Bielecki, D., Borzym, M., Południewski, G., Arciszewki, K., Rózański, A., Zwierz, K. Acta Biochim. Pol. (1999) [Pubmed]
  21. Thermal preference behavior following clonidine, norepinephrine, isoproterenol, and ephedrine. Carlisle, H.J., Frost, T.S., Stock, M.J. Physiol. Behav. (1999) [Pubmed]
  22. Water immersion-induced endocrine alterations in women with EPH gestosis. Doniec-Ulman, I., Kokot, F., Wambach, G., Drab, M. Clin. Nephrol. (1987) [Pubmed]
  23. Changes in blood level of lipid peroxide and vitamin E during pregnancy: clinical significance and relation to the pathogenesis of EPH gestosis. Iioka, H. Gynecol. Obstet. Invest. (1994) [Pubmed]
  24. Association among EPHB2, TrkA, and MYCN expression in low-stage neuroblastomas. Tang, X.X., Evans, A.E., Zhao, H., Cnaan, A., Brodeur, G.M., Ikegaki, N. Med. Pediatr. Oncol. (2001) [Pubmed]
  25. ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers. Sulman, E.P., Tang, X.X., Allen, C., Biegel, J.A., Pleasure, D.E., Brodeur, G.M., Ikegaki, N. Genomics (1997) [Pubmed]
  26. Differential gene expression in non-malignant tumour microenvironment is associated with outcome in follicular lymphoma patients treated with rituximab and CHOP. Harjunpää, A., Taskinen, M., Nykter, M., Karjalainen-Lindsberg, M.L., Nyman, H., Monni, O., Hemmer, S., Yli-Harja, O., Hautaniemi, S., Meri, S., Leppä, S. Br. J. Haematol. (2006) [Pubmed]
  27. Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk. Bennett, B.D., Zeigler, F.C., Gu, Q., Fendly, B., Goddard, A.D., Gillett, N., Matthews, W. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  28. PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2. Böhme, B., Holtrich, U., Wolf, G., Luzius, H., Grzeschik, K.H., Strebhardt, K., Rübsamen-Waigmann, H. Oncogene (1993) [Pubmed]
  29. Incidence and forms of EPH gestosis in twin pregnancy. Schmid-Tannwald, I., Hauser, G.A. Isr. J. Med. Sci. (1976) [Pubmed]
  30. Maternal overnutrition and pregnancy. Curzik, D., Topolovec, Z., Sijanović, S. Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti. (2002) [Pubmed]
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