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Gene Review

Sox7  -  SRY (sex determining region Y)-box 7

Mus musculus

Synonyms: Sox-7, Transcription factor SOX-7, mSOX7
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High impact information on Sox7

  • Sox7 is therefore required for the induction of Gata-4 and Gata-6, and the interplay among these transcription factors plays a crucial role in parietal endoderm differentiation [1].
  • This enhancer carries Sox protein-binding sequences, and our analysis demonstrated that Sox7 and Sox17, which are highly expressed in the extraembryonic endoderm, were involved in enhancer activity [2].
  • However, only Sox7 expression markedly activated the Fgf-3 promoter in these cells [3].
  • Xenopus Sox17alpha, Sox17beta, Sox3 and mouse Sox7 are reported to be negative regulators of the WNT-beta-catenin-TCF signaling pathway [4].
  • Sox7 mRNA was detected during embryonic development in many tissues, most abundantly in brain, heart, lung, kidney, prostate, colon and spleen, suggesting a role in their respective differentiation and development [5].

Biological context of Sox7

  • This Fgf-3 expression was virtually abolished when Sox7 expression was suppressed by RNA interference [3].
  • This cDNA contains an open reading frame (ORF) coding for 362 amino acids, which encompasses an HMG box and exhibits a strong (90%) identity to that of mouse Sox7; the cDNA was named xSox7 in this study [6].
  • Chromosomal mapping analyses localised mouse Sox7 on band D of mouse chromosome 14, and assigned human SOX7 in a region of shared synteny on human chromosome 8 (8p22) [5].

Other interactions of Sox7


  1. Sox7 plays crucial roles in parietal endoderm differentiation in F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression. Futaki, S., Hayashi, Y., Emoto, T., Weber, C.N., Sekiguchi, K. Mol. Cell. Biol. (2004) [Pubmed]
  2. Identification of an enhancer that controls up-regulation of fibronectin during differentiation of embryonic stem cells into extraembryonic endoderm. Shirai, T., Miyagi, S., Horiuchi, D., Okuda-Katayanagi, T., Nishimoto, M., Muramatsu, M., Sakamoto, Y., Nagata, M., Hagiwara, K., Okuda, A. J. Biol. Chem. (2005) [Pubmed]
  3. SOX7 and GATA-4 are competitive activators of Fgf-3 transcription. Murakami, A., Shen, H., Ishida, S., Dickson, C. J. Biol. Chem. (2004) [Pubmed]
  4. Expression of human SOX18 in normal tissues and tumors. Saitoh, T., Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
  5. SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling. Takash, W., Cañizares, J., Bonneaud, N., Poulat, F., Mattéi, M.G., Jay, P., Berta, P. Nucleic Acids Res. (2001) [Pubmed]
  6. Cloning and characterization of Xenopus laevis xSox7 cDNA. Shiozawa, M., Hiraoka, Y., Komatsu, N., Ogawa, M., Sakai, Y., Aiso, S. Biochim. Biophys. Acta (1996) [Pubmed]
  7. Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. Matsui, T., Kanai-Azuma, M., Hara, K., Matoba, S., Hiramatsu, R., Kawakami, H., Kurohmaru, M., Koopman, P., Kanai, Y. J. Cell. Sci. (2006) [Pubmed]
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