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Gene Review:

SOX7 - SRY (sex determining region Y)-box 7

Homo sapiens

Synonyms: Transcription factor SOX-7

Katoh, M., Zhang, C. et al., Takash, W. et al.

Katoh,

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Disease relevance of SOX7

SOX7 mRNA was significantly up-regulated in pancreatic cancer cell lines BxPC-3, PSN-1, Hs766T, and in 4 cases out of 8 cases of primary gastric cancer [1].
On the other hand, SOX7 mRNA was significantly down-regulated in 7 out of 18 cases of primary colorectal tumors, in 4 out of 9 cases of primary breast cancer, in 4 out of 14 cases of primary kidney tumors, and also in some cases of primary lung and prostate cancer [1].
SOX7 mRNA was relatively highly expressed in a gastric cancer cell line MKN45, esophageal cancer cell lines TE2, TE3, TE4, TE5, TE7, TE8, TE11, TE12, and TE13 [1].

High impact information on SOX7

Based on the antagonistic effects of SOX7 and SOX3 (Zhang et al., 2004. Dev. Biol. 273, 23) and their common binding sites in the Xnr5 promoter, we propose a model in which competitive interactions between these two proteins are involved in refining the domain of endodermal differentiation [2].
While no casanova orthologs have been identified in tetrapods, the F-type SOX, SOX7, is supplied maternally in Xenopus (Fawcett and Klymkowsky, 2004. GER 4, 29) [2].
We have previously cloned and characterized human SOX17, constituting a subfamily with SOX7 and SOX18 [1].
SOX7 gene might be one of cancer-associated genes on human chromosome 8p22 [1].
SOX7 mRNA was relatively highly expressed in adult lung, trachea, lymph node, placenta, fetal lung, and heart [1].

Biological context of SOX7

SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling [3].

Analytical, diagnostic and therapeutic context of SOX7

Subsequent RT-PCR and section-based in situ hybridization analyses indicate that SOX7 mRNA is localized to the vegetal region of the blastula-stage embryo [2].

References

Expression of human SOX7 in normal tissues and tumors. Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
SOX7 is an immediate-early target of VegT and regulates Nodal-related gene expression in Xenopus. Zhang, C., Basta, T., Fawcett, S.R., Klymkowsky, M.W. Dev. Biol. (2005) [Pubmed]
SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling. Takash, W., Cañizares, J., Bonneaud, N., Poulat, F., Mattéi, M.G., Jay, P., Berta, P. Nucleic Acids Res. (2001) [Pubmed]

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SOX7	Bos taurus
SOX7	Canis lupus familiaris
sox7	Danio rerio
SOX7	Gallus gallus
SOX7	Macaca mulatta
Sox7	Mus musculus
PINX1	Pan troglodytes
Sox7	Rattus norvegicus
sox7	Xenopus (Silurana) tropicalis

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