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Gene Review

Sult1c1  -  sulfotransferase family, cytosolic, 1C,...

Mus musculus

Synonyms: (PST)G, P-SULT, Phenol sulfotransferase, ST1C1, Stp2, ...
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Disease relevance of Sult1c1

  • Platelets are a rich source of PST and the thrombocytosis observed was probably a compensatory mechanism to raise the levels of PST in the body [1].

High impact information on Sult1c1

  • When several established (phenol-containing) odorants were used as substrates, mouse nasal tissue cytosol showed a significant level of PST activity, as does mouse liver cytosol [2].
  • We have immunolocalized phenol sulfotransferase (PST)G, an isoform of PST in sustentacular cells which reside in the dorso-medial portion of the nasal cavity of the mouse [2].
  • Six amino acid residues of PST have been chosen for mutagenesis studies on the basis of a model of PST and its sequence alignment with those of available cytosolic and membrane-anchored STs [3].
  • In addition to PAPS, phenol sulfotransferase (PST), a member of the ST family, utilizes other nucleotides as substrates with much less catalytic efficiency [Lin, E. S., and Yang, Y. S. (2000) Biochem. Biophys. Res. Commun. 271, 818-822] [3].
  • Rat phenol-preferring sulfotransferase genes (Stp and Stp2): localization to mouse chromosomes 7 and 17 [4].

Biological context of Sult1c1


Other interactions of Sult1c1


  1. Effect of intraperitoneal zinc on the haematological profiles of C57/6J mice. Bay, B.H., Singh, G., Sit, K.H. Singapore medical journal. (1995) [Pubmed]
  2. Zonal distribution of sulfotransferase for phenol in olfactory sustentacular cells. Miyawaki, A., Homma, H., Tamura, H., Matsui, M., Mikoshiba, K. EMBO J. (1996) [Pubmed]
  3. A single mutation converts the nucleotide specificity of phenol sulfotransferase from PAP to AMP. Hsiao, Y.S., Yang, Y.S. Biochemistry (2002) [Pubmed]
  4. Rat phenol-preferring sulfotransferase genes (Stp and Stp2): localization to mouse chromosomes 7 and 17. Khan, A.S., Taylor, B.R., Filie, J.D., Ringer, D.P., Kozak, C.A. Genomics (1995) [Pubmed]
  5. On the nature of rat hepatic and mouse olfactory sulfotransferases. Matsui, M., Tamura, H., Nagai, F., Homma, H., Miyawaki, A., Mikoshiba, K. Chem. Biol. Interact. (1998) [Pubmed]
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