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Gene Review:

Ybey - ybeY metallopeptidase

Mus musculus

Synonyms: 1110068N23Rik, A130042E20Rik, C21orf57, ORF57, ORF66

Schaap, A. et al., Moffat, J.F. et al., Sato, H. et al., Abendroth, A. et al., Ebrahimi, B. et al., et al.

Moffat, Zerboni, Sommer, Heineman, Cohen, Kaneshima, Arvin, Ebrahimi, Dutia, Roberts, Garcia-Ramirez, Dickinson, Stewart, Ghazal, Roy, Nash, Schaap, Fortin, Sommer, Zerboni, Stamatis, Ku, Nolan, Arvin,

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Disease relevance of A130042E20Rik

The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouse [1].
Preventing ORF66 protein expression by stop codon insertion (pOka66S) impaired the growth of the parent Oka (pOka) strain in T cells in SCID-hu T-cell xenografts in vivo and reduced formation of VZV virions [2].
However, preventing ORF66 protein expression only slightly reduced growth in melanoma cells in culture and did not diminish virion formation in these cells [2].
These data indicate that HHV-8 ORF 57 and IE63 possess certain common properties [3].

High impact information on A130042E20Rik

Eliminating ORF66 expression inhibited VZV infectivity for T cells partially but did not impair replication in skin compared with ROka [1].
It also is essential for skin infectivity in vivo, as is glycoprotein C. Expression of ORF66 did not compensate for the absence of the ORF47 protein [1].
T-cell tropism and the role of ORF66 protein in pathogenesis of varicella-zoster virus infection [2].
VZV open reading frame 47 (ORF47) and ORF66 encode protein kinases that phosphorylate several viral proteins, including VZV glycoprotein gE and ORF32, ORF62, and ORF63 proteins [4].
However, cells transfected with a plasmid carrying the early gene ORF66 did result in a significant downregulation of MHC I expression, suggesting that this gene encodes a protein with an immunomodulatory function [5].

Biological context of A130042E20Rik

Using this approach, M4, K3, ORF38, ORF50, ORF57 and ORF73 were designated as immediate-early genes based on cycloheximide treatment [6].

Associations of A130042E20Rik with chemical compounds

The VZV serine/threonine protein kinase encoded by ORF66 is essential for the efficient replication of VZV in T cells [2].

Other interactions of A130042E20Rik

ORF63 transcripts, a hallmark of VZV latency, were also detected in similar numbers of animals infected with the ORF47 and ORF66 mutants and with the parental virus [4].

References

The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouse. Moffat, J.F., Zerboni, L., Sommer, M.H., Heineman, T.C., Cohen, J.I., Kaneshima, H., Arvin, A.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
T-cell tropism and the role of ORF66 protein in pathogenesis of varicella-zoster virus infection. Schaap, A., Fortin, J.F., Sommer, M., Zerboni, L., Stamatis, S., Ku, C.C., Nolan, G.P., Arvin, A.M. J. Virol. (2005) [Pubmed]
The human herpesvirus-8 ORF 57 gene and its properties. Bello, L.J., Davison, A.J., Glenn, M.A., Whitehouse, A., Rethmeier, N., Schulz, T.F., Barklie Clements, J. J. Gen. Virol. (1999) [Pubmed]
Varicella-zoster virus ORF47 protein kinase, which is required for replication in human T cells, and ORF66 protein kinase, which is expressed during latency, are dispensable for establishment of latency. Sato, H., Pesnicak, L., Cohen, J.I. J. Virol. (2003) [Pubmed]
Varicella-zoster virus retains major histocompatibility complex class I proteins in the Golgi compartment of infected cells. Abendroth, A., Lin, I., Slobedman, B., Ploegh, H., Arvin, A.M. J. Virol. (2001) [Pubmed]
Transcriptome profile of murine gammaherpesvirus-68 lytic infection. Ebrahimi, B., Dutia, B.M., Roberts, K.L., Garcia-Ramirez, J.J., Dickinson, P., Stewart, J.P., Ghazal, P., Roy, D.J., Nash, A.A. J. Gen. Virol. (2003) [Pubmed]

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