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MeSH Review

Mice, SCID

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Disease relevance of Mice, SCID


High impact information on Mice, SCID


Chemical compound and disease context of Mice, SCID


Biological context of Mice, SCID


Anatomical context of Mice, SCID


Associations of Mice, SCID with chemical compounds


Gene context of Mice, SCID


Analytical, diagnostic and therapeutic context of Mice, SCID


  1. Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. Bargou, R.C., Emmerich, F., Krappmann, D., Bommert, K., Mapara, M.Y., Arnold, W., Royer, H.D., Grinstein, E., Greiner, A., Scheidereit, C., Dörken, B. J. Clin. Invest. (1997) [Pubmed]
  2. Chloroquine induces human mononuclear phagocytes to inhibit and kill Cryptococcus neoformans by a mechanism independent of iron deprivation. Levitz, S.M., Harrison, T.S., Tabuni, A., Liu, X. J. Clin. Invest. (1997) [Pubmed]
  3. A pituitary gene encodes a protein that produces differentiation of breast and prostate cancer cells. Platica, M., Ivan, E., Holland, J.F., Ionescu, A., Chen, S., Mandeli, J., Unger, P.D., Platica, O. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Human immunodeficiency virus infection of human lymph nodes in the SCID-hu mouse. Kaneshima, H., Shih, C.C., Namikawa, R., Rabin, L., Outzen, H., Machado, S.G., McCune, J.M. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  5. Integrin activation controls metastasis in human breast cancer. Felding-Habermann, B., O'Toole, T.E., Smith, J.W., Fransvea, E., Ruggeri, Z.M., Ginsberg, M.H., Hughes, P.E., Pampori, N., Shattil, S.J., Saven, A., Mueller, B.M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  6. The SCID-hu mouse: a small animal model for HIV infection and pathogenesis. McCune, J., Kaneshima, H., Krowka, J., Namikawa, R., Outzen, H., Peault, B., Rabin, L., Shih, C.C., Yee, E., Lieberman, M. Annu. Rev. Immunol. (1991) [Pubmed]
  7. DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus. Jhappan, C., Morse, H.C., Fleischmann, R.D., Gottesman, M.M., Merlino, G. Nat. Genet. (1997) [Pubmed]
  8. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Zhu, C., Bogue, M.A., Lim, D.S., Hasty, P., Roth, D.B. Cell (1996) [Pubmed]
  9. Generation of intestinal T cells from progenitors residing in gut cryptopatches. Saito, H., Kanamori, Y., Takemori, T., Nariuchi, H., Kubota, E., Takahashi-Iwanaga, H., Iwanaga, T., Ishikawa, H. Science (1998) [Pubmed]
  10. Suppression of HIV infection in AZT-treated SCID-hu mice. McCune, J.M., Namikawa, R., Shih, C.C., Rabin, L., Kaneshima, H. Science (1990) [Pubmed]
  11. Inhibition of HT-29 human colon cancer growth under the renal capsule of severe combined immunodeficient mice by an analogue of 1,25-dihydroxyvitamin D3, DD-003. Tanaka, Y., Wu, A.Y., Ikekawa, N., Iseki, K., Kawai, M., Kobayashi, Y. Cancer Res. (1994) [Pubmed]
  12. A disaccharide precursor of sialyl Lewis X inhibits metastatic potential of tumor cells. Fuster, M.M., Brown, J.R., Wang, L., Esko, J.D. Cancer Res. (2003) [Pubmed]
  13. In vivo cytokine gene therapy of human tumor xenografts in SCID mice by liposome-mediated DNA delivery. Egilmez, N.K., Cuenca, R., Yokota, S.J., Sorgi, F., Bankert, R.B. Gene Ther. (1996) [Pubmed]
  14. Nucleotide analogs related to acyclovir and ganciclovir are effective against murine cytomegalovirus infections in BALB/c and severe combined immunodeficient mice. Smee, D.F., Sugiyama, S.T., Reist, E.J. Antimicrob. Agents Chemother. (1994) [Pubmed]
  15. Cocaine enhances human immunodeficiency virus replication in a model of severe combined immunodeficient mice implanted with human peripheral blood leukocytes. Roth, M.D., Tashkin, D.P., Choi, R., Jamieson, B.D., Zack, J.A., Baldwin, G.C. J. Infect. Dis. (2002) [Pubmed]
  16. Preclinical analysis of cytokine therapy in the SCID-hu mouse. Kyoizumi, S., Murray, L.J., Namikawa, R. Blood (1993) [Pubmed]
  17. The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit. Singleton, B.K., Torres-Arzayus, M.I., Rottinghaus, S.T., Taccioli, G.E., Jeggo, P.A. Mol. Cell. Biol. (1999) [Pubmed]
  18. IFN-gamma gene polymorphisms associate with development of EBV+ lymphoproliferative disease in hu PBL-SCID mice. Dierksheide, J.E., Baiocchi, R.A., Ferketich, A.K., Roychowdhury, S., Pelletier, R.P., Eisenbeis, C.F., Caligiuri, M.A., VanBuskirk, A.M. Blood (2005) [Pubmed]
  19. Tumor-targeted apoptosis by a novel spermine analogue, 1,12-diaziridinyl-4,9-diazadodecane, results in therapeutic efficacy and enhanced radiosensitivity of human prostate cancer. Eiseman, J.L., Rogers, F.A., Guo, Y., Kauffman, J., Sentz, D.L., Klinger, M.F., Callery, P.S., Kyprianou, N. Cancer Res. (1998) [Pubmed]
  20. Arrest of human lung tumor xenograft growth in severe combined immunodeficient mice using doxorubicin encapsulated in sterically stabilized liposomes. Williams, S.S., Alosco, T.R., Mayhew, E., Lasic, D.D., Martin, F.J., Bankert, R.B. Cancer Res. (1993) [Pubmed]
  21. Mutations in the p53 and SCID genes cooperate in tumorigenesis. Nacht, M., Strasser, A., Chan, Y.R., Harris, A.W., Schlissel, M., Bronson, R.T., Jacks, T. Genes Dev. (1996) [Pubmed]
  22. Disseminated human immunodeficiency virus 1 (HIV-1) infection in SCID-hu mice after peripheral inoculation with HIV-1. Kollmann, T.R., Pettoello-Mantovani, M., Zhuang, X., Kim, A., Hachamovitch, M., Smarnworawong, P., Rubinstein, A., Goldstein, H. J. Exp. Med. (1994) [Pubmed]
  23. Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. Orange, J.S., Wang, B., Terhorst, C., Biron, C.A. J. Exp. Med. (1995) [Pubmed]
  24. Species-specific metastasis of human tumor cells in the severe combined immunodeficiency mouse engrafted with human tissue. Shtivelman, E., Namikawa, R. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  25. Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells. Salcedo, R., Zhang, X., Young, H.A., Michael, N., Wasserman, K., Ma, W.H., Martins-Green, M., Murphy, W.J., Oppenheim, J.J. Blood (2003) [Pubmed]
  26. Treatment of Philadelphia leukemia in severe combined immunodeficient mice by combination of cyclophosphamide and bcr/abl antisense oligodeoxynucleotides. Skorski, T., Nieborowska-Skorska, M., Wlodarski, P., Perrotti, D., Hoser, G., Kawiak, J., Majewski, M., Christensen, L., Iozzo, R.V., Calabretta, B. J. Natl. Cancer Inst. (1997) [Pubmed]
  27. Antimyeloma efficacy of thalidomide in the SCID-hu model. Yaccoby, S., Johnson, C.L., Mahaffey, S.C., Wezeman, M.J., Barlogie, B., Epstein, J. Blood (2002) [Pubmed]
  28. Growth of human myeloid leukemias in the human marrow environment of SCID-hu mice. Namikawa, R., Ueda, R., Kyoizumi, S. Blood (1993) [Pubmed]
  29. Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy. Hansen-Algenstaedt, N., Stoll, B.R., Padera, T.P., Dolmans, D.E., Hicklin, D.J., Fukumura, D., Jain, R.K. Cancer Res. (2000) [Pubmed]
  30. Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region. Jin, F., Wienecke, R., Xiao, G.H., Maize, J.C., DeClue, J.E., Yeung, R.S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  31. The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells. Zhang, Y., Wang, X.W., Jelovac, D., Nakanishi, T., Yu, M.H., Akinmade, D., Goloubeva, O., Ross, D.D., Brodie, A., Hamburger, A.W. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  32. Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia. Okamoto, M., Kato, S., Oizumi, K., Kinoshita, M., Inoue, Y., Hoshino, K., Akira, S., McKenzie, A.N., Young, H.A., Hoshino, T. Blood (2002) [Pubmed]
  33. Potentiation of the antiangiogenic ability of linomide by androgen ablation involves down-regulation of vascular endothelial growth factor in human androgen-responsive prostatic cancers. Joseph, I.B., Isaacs, J.T. Cancer Res. (1997) [Pubmed]
  34. Effective adoptive immunotherapy by T-LAK cells retargeted with bacterial superantigen-conjugated antibody to MUC1 in xenografted severe combined immunodeficient mice. Shinoda, M., Kudo, T., Suzuki, M., Katayose, Y., Sakurai, N., Saeki, H., Kodama, H., Fukuhara, K., Imai, K., Hinoda, Y., Matsuno, S. Cancer Res. (1998) [Pubmed]
  35. Mullerian inhibiting substance suppresses tumor growth in the C3(1)T antigen transgenic mouse mammary carcinoma model. Gupta, V., Carey, J.L., Kawakubo, H., Muzikansky, A., Green, J.E., Donahoe, P.K., MacLaughlin, D.T., Maheswaran, S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  36. Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells. Hattori, K., Heissig, B., Tashiro, K., Honjo, T., Tateno, M., Shieh, J.H., Hackett, N.R., Quitoriano, M.S., Crystal, R.G., Rafii, S., Moore, M.A. Blood (2001) [Pubmed]
  37. Antibody targeting of doxorubicin-loaded liposomes suppresses the growth and metastatic spread of established human lung tumor xenografts in severe combined immunodeficient mice. Sugano, M., Egilmez, N.K., Yokota, S.J., Chen, F.A., Harding, J., Huang, S.K., Bankert, R.B. Cancer Res. (2000) [Pubmed]
  38. Telomerase- and alternative telomere lengthening-independent telomere stabilization in a metastasis-derived human non-small cell lung cancer cell line: effect of ectopic hTERT. Brachner, A., Sasgary, S., Pirker, C., Rodgarkia, C., Mikula, M., Mikulits, W., Bergmeister, H., Setinek, U., Wieser, M., Chin, S.F., Caldas, C., Micksche, M., Cerni, C., Berger, W. Cancer Res. (2006) [Pubmed]
  39. Regulation of keratin 9 in nonpalmoplantar keratinocytes by palmoplantar fibroblasts through epithelial-mesenchymal interactions. Yamaguchi, Y., Itami, S., Tarutani, M., Hosokawa, K., Miura, H., Yoshikawa, K. J. Invest. Dermatol. (1999) [Pubmed]
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