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Gene Review

Mlh3  -  mutL homolog 3 (E coli)

Mus musculus

Synonyms: AV125803, BB126472
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High impact information on Mlh3


Biological context of Mlh3

  • Our results show that Mlh3 has an essential and distinct role in mammalian meiosis [1].
  • Mlh3 deficiency alone causes microsatellite instability, impaired DNA-damage response, and increased gastrointestinal tumor susceptibility [4].


  1. Meiotic arrest and aneuploidy in MLH3-deficient mice. Lipkin, S.M., Moens, P.B., Wang, V., Lenzi, M., Shanmugarajah, D., Gilgeous, A., Thomas, J., Cheng, J., Touchman, J.W., Green, E.D., Schwartzberg, P., Collins, F.S., Cohen, P.E. Nat. Genet. (2002) [Pubmed]
  2. MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability. Lipkin, S.M., Wang, V., Jacoby, R., Banerjee-Basu, S., Baxevanis, A.D., Lynch, H.T., Elliott, R.M., Collins, F.S. Nat. Genet. (2000) [Pubmed]
  3. A role for Mlh3 in somatic hypermutation. Li, Z., Peled, J.U., Zhao, C., Svetlanov, A., Ronai, D., Cohen, P.E., Scharff, M.D. DNA Repair (Amst.) (2006) [Pubmed]
  4. Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse. Chen, P.C., Dudley, S., Hagen, W., Dizon, D., Paxton, L., Reichow, D., Yoon, S.R., Yang, K., Arnheim, N., Liskay, R.M., Lipkin, S.M. Cancer Res. (2005) [Pubmed]
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