Gene Review:
MLH3 - mutL homolog 3
Homo sapiens
Synonyms:
DNA mismatch repair protein Mlh3, MutL protein homolog 3
- Little evidence for involvement of MLH3 in colorectal cancer predisposition. Hienonen, T., Laiho, P., Salovaara, R., Mecklin, J.P., Järvinen, H., Sistonen, P., Peltomäki, P., Lehtonen, R., Nupponen, N.N., Launonen, V., Karhu, A., Aaltonen, L.A. Int. J. Cancer (2003)
- Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair. Cannavo, E., Marra, G., Sabates-Bellver, J., Menigatti, M., Lipkin, S.M., Fischer, F., Cejka, P., Jiricny, J. Cancer Res. (2005)
- A role for MLH3 in hereditary nonpolyposis colorectal cancer. Wu, Y., Berends, M.J., Sijmons, R.H., Mensink, R.G., Verlind, E., Kooi, K.A., van der Sluis, T., Kempinga, C., van dDer Zee, A.G., Hollema, H., Buys, C.H., Kleibeuker, J.H., Hofstra, R.M. Nat. Genet. (2001)
- MLH3 mutation in endometrial cancer. Taylor, N.P., Powell, M.A., Gibb, R.K., Rader, J.S., Huettner, P.C., Thibodeau, S.N., Mutch, D.G., Goodfellow, P.J. Cancer Res. (2006)
- Mutation screening of mismatch repair gene Mlh3 in familial esophageal cancer. Liu, H.X., Li, Y., Jiang, X.D., Yin, H.N., Zhang, L., Wang, Y., Yang, J. World J. Gastroenterol. (2006)
- MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability. Lipkin, S.M., Wang, V., Jacoby, R., Banerjee-Basu, S., Baxevanis, A.D., Lynch, H.T., Elliott, R.M., Collins, F.S. Nat. Genet. (2000)
- Mediating mismatch repair. Jiricny, J. Nat. Genet. (2000)
- The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role for this MutL homolog in mammalian meiotic recombination. Santucci-Darmanin, S., Neyton, S., Lespinasse, F., Saunières, A., Gaudray, P., Paquis-Flucklinger, V. Hum. Mol. Genet. (2002)
- Extreme heterogeneity in the molecular events leading to the establishment of chiasmata during meiosis i in human oocytes. Lenzi, M.L., Smith, J., Snowden, T., Kim, M., Fishel, R., Poulos, B.K., Cohen, P.E. Am. J. Hum. Genet. (2005)
- Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: Evidence for somatic mutation in colorectal cancers. Lipkin, S.M., Wang, V., Stoler, D.L., Anderson, G.R., Kirsch, I., Hadley, D., Lynch, H.T., Collins, F.S. Hum. Mutat. (2001)
- The system VO2+ +oxidized glutathione: a potentiometric and spectroscopic study. Pessoa, J.C., Tomaz, I., Kiss, T., Buglyó, P. J. Inorg. Biochem. (2001)
- Germline and somatic mutation analysis of MLH3 in MSI-positive colorectal cancer. Loukola, A., Vilkki, S., Singh, J., Launonen, V., Aaltonen, L.A. Am. J. Pathol. (2000)
- Lynch syndrome genes. Peltomäki, P. Fam. Cancer (2005)
- The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2. Kondo, E., Horii, A., Fukushige, S. Nucleic Acids Res. (2001)
- The role of hMLH3 in familial colorectal cancer. Liu, H.X., Zhou, X.L., Liu, T., Werelius, B., Lindmark, G., Dahl, N., Lindblom, A. Cancer Res. (2003)
- Conditional nuclear localization of hMLH3 suggests a minor activity in mismatch repair and supports its role as a low-risk gene in HNPCC. Korhonen, M.K., Raevaara, T.E., Lohi, H., Nystr??m, M. Oncol. Rep. (2007)