Disease relevance of Vamp8

• In addition, VAMP8-/- mice were partially resistant to supramaximal caerulein-induced pancreatitis [1].
• Tetanus toxin does block the residual release from permeabilized VAMP-8(-/-) platelets, suggesting a secondary role for VAMP-2 and/or -3 [2].

High impact information on Vamp8

• These data imply a ranked redundancy of v-SNARE usage in platelets and suggest that VAMP-8(-/-) mice will be a useful in vivo model to study platelet exocytosis in hemostasis and vascular inflammation [2].
• Endobrevin/VAMP-8 Is the Primary v-SNARE for the Platelet Release Reaction [2].
• We demonstrate that VAMP-8 is required for release from dense core granules, alpha granules, and lysosomes [2].
• The proteins are broadly expressed; however, syntaxin 13 is enriched in brain and VAMP 8 in kidney [3].
• Endobrevin maps to chromosome 2 in human and chromosome 6 in mouse [4].

Biological context of Vamp8

• These results suggest a major physiological role of VAMP8 in regulated exocytosis of pancreatic acinar cells by serving as a v-SNARE of zymogen granules [1].

Regulatory relationships of Vamp8

• In this study, through targeted gene knockout in mice, we establish that VAMP8/endobrevin is a major player in regulated exocytosis of the exocrine pancreas [1].

Other interactions of Vamp8

• VAMP8 null acinar cells contained three times more zymogen granules than control acinar cells [1].
• VAMP8-/- mice developed normally but showed severe defects in the pancreas [1].

References