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Chemical Compound Review

Release     3-chloro-5-methyl-4-nitro-1H- pyrazole

Synonyms: Pyrazachlor, CMN-Pyrazole, AG-G-60430, SureCN2549734, STOCK3S-05165, ...
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Disease relevance of Release


Psychiatry related information on Release

  • METHODS: Cardiovascular risk and risk reduction were analyzed in five subgroups defined by quintiles (Q) of pretreatment resting HR in the Metoprolol Controlled Release/Extended Release Randomized Intervention Trial in Chronic Heart Failure (MERIT-HF) [6].
  • Despite shorter Release reaction times (RTs) for gender decisions than semantic ones, Release and Hold ERPs diverged 84 ms earlier in the semantic context than in the gender context, indicating faster onset for the processing of meaning [7].
  • Fourteen patients enrolled in rehabilitation and 12 controls were administered the Release from Proactive Inhibition paradigm involving trials of recalling words from the same category followed by a shift to a new category or continued presentation of identical material [8].
  • No precise etiologic basis is yet clearly identifiable; however, this report offers support for a central mechanism explained by the "Release Theory." Additionally, it appears that such hallucinations might be managed safely with psychotropic medications other than antipsychotics [9].
  • All patients were assessed using CAMCOG (Cambridge Cognitive Examination), tests examining frontal lobe function (Behavioural Dyscontrol Scale [BDYS], Trail-Making Tests A and B, Controlled Word Association Test) and a scale for primitive reflexes (Frontal Release Signs Scale) [10].

High impact information on Release


Chemical compound and disease context of Release


Biological context of Release


Anatomical context of Release

  • SAD: A Presynaptic Kinase Associated with Synaptic Vesicles and the Active Zone Cytomatrix that Regulates Neurotransmitter Release [26].
  • CONCLUSIONS: Release of ETs in the intestinal mucosa increased in sensitized animals after EA challenge [27].
  • Clearance of gut-derived endotoxins by the liver. Release and modification of 3H, 14C-lipopolysaccharide by isolated rat Kupffer cells [28].
  • By contrast, only 2 patients and 1 patient, respectively, without side-branch occlusion had slight rises in CKMB and troponin T. Release of the contractile protein troponin T reflects more severe damage to myocytes than simple leakage of CKMB [29].
  • BACKGROUND & AIMS: Release of 5-hydroxytryptamine (5-HT) from mucosal enterochromaffin cells and activation of 5-HT(3) receptors (5-HT(3)Rs) on neurons in the gut wall is important in the response of the gut to the luminal environment [30].

Associations of Release with other chemical compounds


Gene context of Release


Analytical, diagnostic and therapeutic context of Release

  • Studies on the mechanism of natural killer (NK) cell-mediated cytotoxicity (CMC). I. Release of cytotoxic factors specific for NK-sensitive target cells (NKCF) during co-culture of NK effector cells with NK target cells [41].
  • BACKGROUND: Release of endogenous proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha in response to endotoxin is responsible for the production of large amounts of nitric oxide (NO), which may exert detrimental effects on the myocardium in animal models, isolated hearts, and isolated cardiac myocytes [42].
  • Oxygen radical generation induced by postischemic reperfusion can overwhelm endogenous radical scavenging systems, resulting in "oxidative stress." Release of oxidized glutathione (GSSG) upon reflow has been taken as evidence for the occurrence of oxidative stress in postischemic hearts [43].
  • In patients with inferior infarction, neither enzyme release (r = 0.30 to 0.40) nor ejection fraction (r = 0.22 to 0.31) correlated well with the ECG indices of infarct size [44].
  • 3. Release of catecholamines by the ionophore was dependent on the calcium concentration of the perfusion medium [45].


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  14. Functional Maturation of CA1 Synapses Involves Activity-Dependent Loss of Tonic Kainate Receptor-Mediated Inhibition of Glutamate Release. Lauri, S.E., Vesikansa, A., Segerstråle, M., Collingridge, G.L., Isaac, J.T., Taira, T. Neuron (2006) [Pubmed]
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  16. ATP-Sensitive K+ Channels Regulate the Release of GABA in the Ventromedial Hypothalamus During Hypoglycemia. Chan, O., Lawson, M., Zhu, W., Beverly, J.L., Sherwin, R.S. Diabetes (2007) [Pubmed]
  17. Francisella tularensis-Infected Macrophages Release Prostaglandin E2 that Blocks T Cell Proliferation and Promotes a Th2-Like Response. Woolard, M.D., Wilson, J.E., Hensley, L.L., Jania, L.A., Kawula, T.H., Drake, J.R., Frelinger, J.A. J. Immunol. (2007) [Pubmed]
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  19. Induction of Vascular Leakage and Blood Pressure Lowering through Kinin Release by a Serine Proteinase from Aeromonas sobria. Imamura, T., Kobayashi, H., Khan, R., Nitta, H., Okamoto, K. J. Immunol. (2006) [Pubmed]
  20. Rasp21 sequences opposite the nucleotide binding pocket are required for GRF-mediated nucleotide release. Leonardsen, L., DeClue, J.E., Lybaek, H., Lowy, D.R., Willumsen, B.M. Oncogene (1996) [Pubmed]
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  22. Arabidopsis Separase AESP Is Essential for Embryo Development and the Release of Cohesin during Meiosis. Liu, Z., Makaroff, C.A. Plant Cell (2006) [Pubmed]
  23. Cx36-Mediated Coupling Reduces {beta}-Cell Heterogeneity, Confines the Stimulating Glucose Concentration Range, and Affects Insulin Release Kinetics. Speier, S., Gjinovci, A., Charollais, A., Meda, P., Rupnik, M. Diabetes (2007) [Pubmed]
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  25. The active site of antithrombin. Release of the same proteolytically cleaved form of the inhibitor from complexes with factor IXa, factor Xa, and thrombin. Björk, I., Jackson, C.M., Jörnvall, H., Lavine, K.K., Nordling, K., Salsgiver, W.J. J. Biol. Chem. (1982) [Pubmed]
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  29. Side-branch occlusion during percutaneous transluminal coronary angioplasty. Talasz, H., Genser, N., Mair, J., Dworzak, E.A., Friedrich, G., Moes, N., Mühlberger, V., Puschendorf, B. Lancet (1992) [Pubmed]
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  33. Sustained Activity of Calcium Release-activated Calcium Channels Requires Translocation of Mitochondria to the Plasma Membrane. Quintana, A., Schwarz, E.C., Schwindling, C., Lipp, P., Kaestner, L., Hoth, M. J. Biol. Chem. (2006) [Pubmed]
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