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Gene Review

Stx12  -  syntaxin 12

Mus musculus

Synonyms: AI850350, AU041521, Stx13, Syntaxin-12, syntaxin 13
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High impact information on Stx12


Biological context of Stx12


Anatomical context of Stx12

  • We show that in phagocytic cells syntaxin 13 is localized to the recycling endosome compartment, while syntaxin 7 is found in late endosomes/lysosomes [4].
  • Both proteins are recruited to the phagosome, but syntaxin 13 is acquired earlier and rapidly recycles off the phagosome, while syntaxin 7 is recruited later and continues to accumulate throughout the maturation process [4].
  • Syntaxin 13 is a developmentally regulated SNARE involved in neurite outgrowth and endosomal trafficking [6].
  • Finally, overexpression of full-length syntaxin 13 enhanced neurite outgrowth in NGF-stimulated PC12 cells, whilst it had no effect on regulated secretion [6].
  • While usually restricted to the soma of neurons, we transiently detected syntaxin 13 in dendrites of pyramidal neurons during the first postnatal week [7].

Associations of Stx12 with chemical compounds


Other interactions of Stx12

  • The proteins are broadly expressed; however, syntaxin 13 is enriched in brain and VAMP 8 in kidney [9].
  • The spatial and temporal pattern of sr-PLP and sr-DM20 expression is very similar to that of the endosomal protein, syntaxin 13, consistent with the finding that the sr-PLPs may play a role in vesicular transport in neurons [10].

Analytical, diagnostic and therapeutic context of Stx12


  1. The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency. Huang, L., Kuo, Y.M., Gitschier, J. Nat. Genet. (1999) [Pubmed]
  2. Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. Prekeris, R., Klumperman, J., Chen, Y.A., Scheller, R.H. J. Cell Biol. (1998) [Pubmed]
  3. SNAP25, but not syntaxin 1A, recycles via an ARF6-regulated pathway in neuroendocrine cells. Aikawa, Y., Xia, X., Martin, T.F. Mol. Biol. Cell (2006) [Pubmed]
  4. Syntaxins 13 and 7 function at distinct steps during phagocytosis. Collins, R.F., Schreiber, A.D., Grinstein, S., Trimble, W.S. J. Immunol. (2002) [Pubmed]
  5. Genetic segregation of brain gene expression identifies retinaldehyde binding protein 1 and syntaxin 12 as potential contributors to ethanol preference in mice. Treadwell, J.A., Pagniello, K.B., Singh, S.M. Behav. Genet. (2004) [Pubmed]
  6. Syntaxin 13 is a developmentally regulated SNARE involved in neurite outgrowth and endosomal trafficking. Hirling, H., Steiner, P., Chaperon, C., Marsault, R., Regazzi, R., Catsicas, S. Eur. J. Neurosci. (2000) [Pubmed]
  7. Developmental and spatial expression pattern of syntaxin 13 in the mouse central nervous system. Sarria, J.C., Catsicas, S., Hornung, J.P., Hirling, H. Cell Tissue Res. (2002) [Pubmed]
  8. Interaction of Vesl-1L/Homer 1c with syntaxin 13. Minakami, R., Kato, A., Sugiyama, H. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  9. Seven novel mammalian SNARE proteins localize to distinct membrane compartments. Advani, R.J., Bae, H.R., Bock, J.B., Chao, D.S., Doung, Y.C., Prekeris, R., Yoo, J.S., Scheller, R.H. J. Biol. Chem. (1998) [Pubmed]
  10. Soma-restricted products of the myelin proteolipid gene are expressed primarily in neurons in the developing mouse nervous system. Jacobs, E.C., Bongarzone, E.R., Campagnoni, C.W., Kampf, K., Campagnoni, A.T. Dev. Neurosci. (2003) [Pubmed]
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