The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

VAMP8  -  vesicle-associated membrane protein 8

Homo sapiens

Synonyms: EDB, Endobrevin, VAMP-8, Vesicle-associated membrane protein 8
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of VAMP8


Psychiatry related information on VAMP8

  • We recorded with surface EMG all movements of the muscles said to be involved in PLMs (extensor digitorum brevis, EDB; tibialis anterior, TA; biceps femoris, BF; tensor fasciae latae; TFL) as well as the quadriceps (Q) and soleus (S) muscles in 12 patients with restless legs syndrome combined with PLMD [6].

High impact information on VAMP8


Chemical compound and disease context of VAMP8

  • Acute toxicity of EDB and aldicarb to young of two estuarine fish species [10].
  • We present immunolocalization data on tenascin (Ten), and extradomains A and B (EDA-, EDB-) and oncofetal (Onc-) isoforms of cellular fibronectin (cFn), and alpha 1-6 and alpha v and beta 1-4 integrin subunits on cryosections of normal human breast, the spectrum of fibrocystic disease (FCD), and benign and malignant breast neoplasms [11].

Biological context of VAMP8


Anatomical context of VAMP8


Associations of VAMP8 with chemical compounds

  • Endobrevin overexpression increased the amount of GABA released from MIN6 cells; in contrast, it decreased the glucose-stimulated insulin release from rat islets, MIN6 and INS1-D cells to approximately 50% of the control levels [3].
  • Glutathione-dependent DNA damage by EDB was also demonstrated in human hepatocyte preparations [17].
  • The sensor elements have been prepared by coating the sensor surface with tumor marker EDB-fibronectin by means of SAM technique and carbodiimide chemistry [18].
  • Vinyl bromide, which is a suspected carcinogen, is a minor product in lab studies, but so far there are no reports linking its presence with EDB in the field.(ABSTRACT TRUNCATED AT 400 WORDS)[19]
  • Specific incidents of concern related to pesticides in food including EDB in grain and grain products, aldicarb in watermelon, demeton-methyl in wine, DDT in fish, S,S,S-tributylphosphorotrithioate in chili peppers, and daminozide in apples and processed apple products are described [20].

Other interactions of VAMP8


Analytical, diagnostic and therapeutic context of VAMP8

  • The subcellular localization of GFP-endobrevin was visualized by confocal laser microscopy [3].
  • Western blots of the PTF-CM identified FN containing the EDA but not the EDB domain [22].
  • EXPERIMENTAL DESIGN: Frozen tissue samples from biopsies of acute (n = 14) and chronic (n = 12) human renal allograft rejections were studied to compare distribution of tenascin, the extradomains A and B (EDA, EDB), and oncofetal (Onc) isoforms of cellular fibronectin (cFn) [23].
  • EDB has been shown to be mutagenic in numerous bacterial assays, in fungi, in plants, in insects, and in mammalian cell culture [24].
  • Samples are mixed with water and sparged with nitrogen for 1 h with stirring in a water bath at 100 degrees C. The EDB collected on the adsorbent Tenax TA is eluted with hexane and determined by gas chromatography (GC) with electron capture (EC) and confirmed with Hall electrolytic conductivity (HECD) detection using a second GC column [25].


  1. VAMP5 and VAMP8 are most likely not involved in primary open-angle glaucoma. Brinkman, J.F., Ottenheim, C.P., de Jong, L.A., Zegers, R.H., de Smet, M.D., de Jong, P.T., Bergen, A.A. Mol. Vis. (2005) [Pubmed]
  2. Endobrevin/VAMP-8 Is the Primary v-SNARE for the Platelet Release Reaction. Ren, Q., Barber, H.K., Crawford, G.L., Karim, Z.A., Zhao, C., Choi, W., Wang, C.C., Hong, W., Whiteheart, S.W. Mol. Biol. Cell (2007) [Pubmed]
  3. Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules. Nagamatsu, S., Nakamichi, Y., Watanabe, T., Matsushima, S., Yamaguchi, S., Ni, J., Itagaki, E., Ishida, H. J. Cell. Sci. (2001) [Pubmed]
  4. Promoter architecture modulates CFTR exon 9 skipping. Pagani, F., Stuani, C., Zuccato, E., Kornblihtt, A.R., Baralle, F.E. J. Biol. Chem. (2003) [Pubmed]
  5. Expression of EDA/EDB isoforms of fibronectin in papillary carcinoma of the thyroid. Scarpino, S., Stoppacciaro, A., Pellegrini, C., Marzullo, A., Zardi, L., Tartaglia, F., Viale, G., Ruco, L.P. J. Pathol. (1999) [Pubmed]
  6. Activity patterns of leg muscles in periodic limb movement disorder. de Weerd, A.W., Rijsman, R.M., Brinkley, A. J. Neurol. Neurosurg. Psychiatr. (2004) [Pubmed]
  7. Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion. Polgár, J., Chung, S.H., Reed, G.L. Blood (2002) [Pubmed]
  8. Regulation of fibronectin EDA exon alternative splicing: possible role of RNA secondary structure for enhancer display. Muro, A.F., Caputi, M., Pariyarath, R., Pagani, F., Buratti, E., Baralle, F.E. Mol. Cell. Biol. (1999) [Pubmed]
  9. Bridging the gap between developmental systems theory and evolutionary developmental biology. Robert, J.S., Hall, B.K., Olson, W.M. Bioessays (2001) [Pubmed]
  10. Acute toxicity of EDB and aldicarb to young of two estuarine fish species. Landau, M., Tucker, J.W. Bulletin of environmental contamination and toxicology. (1984) [Pubmed]
  11. Distribution of tenascin, cellular fibronectins and integrins in the normal, hyperplastic and neoplastic breast. Koukoulis, G.K., Howeedy, A.A., Korhonen, M., Virtanen, I., Gould, V.E. J. Submicrosc. Cytol. Pathol. (1993) [Pubmed]
  12. Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment. Paumet, F., Le Mao, J., Martin, S., Galli, T., David, B., Blank, U., Roa, M. J. Immunol. (2000) [Pubmed]
  13. Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis. Zhao, W.M., Seki, A., Fang, G. Mol. Biol. Cell (2006) [Pubmed]
  14. Basal metabolism of obese adolescents: inconsistent diet and exercise effects. Katch, V., Becque, M.D., Marks, C., Moorehead, C., Rocchini, A. Am. J. Clin. Nutr. (1988) [Pubmed]
  15. Identification of the endoplasmic reticulum targeting signal in vesicle-associated membrane proteins. Kim, P.K., Hollerbach, C., Trimble, W.S., Leber, B., Andrews, D.W. J. Biol. Chem. (1999) [Pubmed]
  16. Pancreatic Acinar Cells Express Vesicle-associated Membrane Protein 2- and 8-Specific Populations of Zymogen Granules with Distinct and Overlapping Roles in Secretion. Weng, N., Thomas, D.D., Groblewski, G.E. J. Biol. Chem. (2007) [Pubmed]
  17. Activation of dihaloalkanes by glutathione conjugation and formation of DNA adducts. Guengerich, F.P., Peterson, L.A., Cmarik, J.L., Koga, N., Inskeep, P.B. Environ. Health Perspect. (1987) [Pubmed]
  18. Specific targeting of ultrasound contrast agent (USCA) for diagnostic application: an in vitro feasibility study based on SAW biosensor. Joseph, S., Gronewold, T.M., Schlensog, M.D., Olbrich, C., Quandt, E., Famulok, M., Schirner, M. Biosensors & bioelectronics. (2005) [Pubmed]
  19. Environmental chemistry of ethylene dibromide in soil and ground water. Pignatello, J.J., Cohen, S.Z. Reviews of environmental contamination and toxicology. (1990) [Pubmed]
  20. Pesticides and food safety. Fan, A.M., Jackson, R.J. Regulatory toxicology and pharmacology : RTP. (1989) [Pubmed]
  21. Role of VAMP-2, VAMP-7, and VAMP-8 in constitutive exocytosis from HSY cells. Oishi, Y., Arakawa, T., Tanimura, A., Itakura, M., Takahashi, M., Tajima, Y., Mizoguchi, I., Takuma, T. Histochem. Cell Biol. (2006) [Pubmed]
  22. Soluble fibronectin promotes migration of oral squamous-cell carcinoma cells. Liu, H., Chen, B., Zardi, L., Ramos, D.M. Int. J. Cancer (1998) [Pubmed]
  23. Differential distribution of tenascin and cellular fibronectins in acute and chronic renal allograft rejection. Gould, V.E., Martinez-Lacabe, V., Virtanen, I., Sahlin, K.M., Schwartz, M.M. Lab. Invest. (1992) [Pubmed]
  24. Ethylene dibromide: toxicology and risk assessment. Alexeeff, G.V., Kilgore, W.W., Li, M.Y. Reviews of environmental contamination and toxicology. (1990) [Pubmed]
  25. Purge and trap method for determination of ethylene dibromide in table-ready foods. Heikes, D.L. Journal - Association of Official Analytical Chemists. (1985) [Pubmed]
WikiGenes - Universities