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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Fam105a  -  family with sequence similarity 105, member A

Mus musculus

Synonyms: BC052328, Inactive ubiquitin thioesterase FAM105A
 
 
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High impact information on BC052328

  • We thus conclude that Trio is essential for late embryonic development, and that Trio functions in fetal skeletal muscle formation and in the organization of neural tissues [1].
  • The proliferation of trio(-/-) secondary myoblasts appeared normal, suggesting that Trio may regulate secondary myoblast alignment or fusion. trio(-/-) embryos also displayed aberrant organization in several regions within the brain, including the hippocampal formation and olfactory bulb [1].
  • The DH-GEF family member Trio is of particular interest because it is a multifunctional protein possessing two GEF domains, as well as a protein serine/threonine kinase domain, and trio-like genes in Caenorhabditis elegans and Drosophila were shown to function in neural migration and axon guidance [1].
  • Solo/Trio8, a membrane-associated short isoform of Trio, modulates endosome dynamics and neurite elongation [2].
 

Anatomical context of BC052328

References

  1. Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos. O'Brien, S.P., Seipel, K., Medley, Q.G., Bronson, R., Segal, R., Streuli, M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Solo/Trio8, a membrane-associated short isoform of Trio, modulates endosome dynamics and neurite elongation. Sun, Y.J., Nishikawa, K., Yuda, H., Wang, Y.L., Osaka, H., Fukazawa, N., Naito, A., Kudo, Y., Wada, K., Aoki, S. Mol. Cell. Biol. (2006) [Pubmed]
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