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Gene Review

Peo1  -  progressive external ophthalmoplegia 1...

Mus musculus

Synonyms: D19Ertd626e, PEO, Progressive external ophthalmoplegia 1 protein homolog, T7 gp4-like protein with intramitochondrial nucleoid localization, T7-like mitochondrial DNA helicase, ...
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Disease relevance of Peo1


High impact information on Peo1

  • Others have used various methods to immobilize nonadhesive PEO-based polymers on surfaces to inhibit protein absorption and cell adhesion [2].
  • In this study, we have investigated a technique for covalently immobilizing fibronectin to the PEO-containing triblock copolymer Pluronic F108 ("F108") [3].
  • Improved calcification resistance and biocompatibility of tissue patch grafted with sulfonated PEO or heparin after glutaraldehyde fixation [4].
  • This method involved the additional grafting of sulfonated PEO (PEO-SO(3)) or heparin after conventional glutaraldehyde (GA) fixation of bovine pericardium (BP) [4].
  • PEO/PPO/PEO triblock copolymers (Pluronic F108) were equipped with terminal pyridyl disulfide functionalities and used to tether RGD containing peptides to polystyrene (PS) [5].

Anatomical context of Peo1

  • The carrier PEO does not affect B-cell responses to DNP-PEO or T-cell response to succinyl concanavalin A [6].
  • Adhesion behavior of cells to the surface of physical hydrogel membranes prepared by water-induced self-organization of precisely synthesized ABA-triblock copolymers comprised of poly(beta-benzyl L-aspartate) (PBLA) as A segment and poly(ethylene oxide) (PEO, molecular weight = 20 000) as the B segment were investigated [7].

Associations of Peo1 with chemical compounds

  • In this study, we report the application of a well-characterized, commercially available, PEO-terminated triblock polymer (Pluronic F108) to create micropatterned nonadhesive domains on a variety of biomaterials that deter cell adhesion for up to 4 weeks in culture [2].

Analytical, diagnostic and therapeutic context of Peo1


  1. Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice. Tyynismaa, H., Mjosund, K.P., Wanrooij, S., Lappalainen, I., Ylikallio, E., Jalanko, A., Spelbrink, J.N., Paetau, A., Suomalainen, A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Engineering protein and cell adhesivity using PEO-terminated triblock polymers. Liu, V.A., Jastromb, W.E., Bhatia, S.N. J. Biomed. Mater. Res. (2002) [Pubmed]
  3. A novel surfactant-based immobilization method for varying substrate-bound fibronectin. Webb, K., Caldwell, K.D., Tresco, P.A. J. Biomed. Mater. Res. (2001) [Pubmed]
  4. Improved calcification resistance and biocompatibility of tissue patch grafted with sulfonated PEO or heparin after glutaraldehyde fixation. Lee, W.K., Park, K.D., Kim, Y.H., Suh, H., Park, J.C., Lee, J.E., Sun, K., Baek, M.J., Kim, H.M., Kim, S.H. J. Biomed. Mater. Res. (2001) [Pubmed]
  5. Surface modification for controlled studies of cell-ligand interactions. Neff, J.A., Tresco, P.A., Caldwell, K.D. Biomaterials (1999) [Pubmed]
  6. Thymus-independent immunogenicity in vitro of the divalent antigen DNP-polyethylene oxide. Peacock, J.S., Bush, J., Krakauer, H., Hiernaux, J., DeLisi, C., Barisas, B.G. Cell. Immunol. (1983) [Pubmed]
  7. Adhesion behavior of peritoneal cells on the surface of self-assembled triblock copolymer hydrogels. Tanaka, S., Ogura, A., Kaneko, T., Murata, Y., Akashi, M. Biomacromolecules (2004) [Pubmed]
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