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Gene Review

TRIM32  -  tripartite motif containing 32

Homo sapiens

Synonyms: 72 kDa Tat-interacting protein, BBS11, E3 ubiquitin-protein ligase TRIM32, HT2A, LGMD2H, ...
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Disease relevance of TRIM32


High impact information on TRIM32


Biological context of TRIM32


Anatomical context of TRIM32

  • We present data further demonstrating that the interaction between the activation domain of HIV-1 Tat and the HT2A protein can be readily detected in the mammalian cell nucleus [3].
  • Trim32 expression increased the transcriptional activity of NFkappaB in epidermal keratinocytes, both under basal treatment and after UVB/TNFalpha treatment [7].
  • Their interaction was induced by treatment with UVB/TNFalpha and involved redistribution of Piasy from the nucleus to the cytoplasm, where it accumulated in cytoplasmic granules that colocalized with Trim32 [7].

Associations of TRIM32 with chemical compounds


Other interactions of TRIM32

  • The remaining two sons (7 and 10 years old), presented with mild decrease in stamina, had normal neuromuscular examinations and were found to be homozygous for the FKRP mutation in addition to the TRIM32 mutation [10].
  • Ubiquitination of Piasy by Trim32 could be reproduced in vitro using purified components [7].


  1. Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene. Frosk, P., Weiler, T., Nylen, E., Sudha, T., Greenberg, C.R., Morgan, K., Fujiwara, T.M., Wrogemann, K. Am. J. Hum. Genet. (2002) [Pubmed]
  2. Commonality of TRIM32 mutation in causing sarcotubular myopathy and LGMD2H. Schoser, B.G., Frosk, P., Engel, A.G., Klutzny, U., Lochmüller, H., Wrogemann, K. Ann. Neurol. (2005) [Pubmed]
  3. Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins. Fridell, R.A., Harding, L.S., Bogerd, H.P., Cullen, B.R. Virology (1995) [Pubmed]
  4. Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11). Chiang, A.P., Beck, J.S., Yen, H.J., Tayeh, M.K., Scheetz, T.E., Swiderski, R.E., Nishimura, D.Y., Braun, T.A., Kim, K.Y., Huang, J., Elbedour, K., Carmi, R., Slusarski, D.C., Casavant, T.L., Stone, E.M., Sheffield, V.C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  5. RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties. Horn, E.J., Albor, A., Liu, Y., El-Hizawi, S., Vanderbeek, G.E., Babcock, M., Bowden, G.T., Hennings, H., Lozano, G., Weinberg, W.C., Kulesz-Martin, M. Carcinogenesis (2004) [Pubmed]
  6. The most common mutation in FKRP causing limb girdle muscular dystrophy type 2I (LGMD2I) may have occurred only once and is present in Hutterites and other populations. Frosk, P., Greenberg, C.R., Tennese, A.A., Lamont, R., Nylen, E., Hirst, C., Frappier, D., Roslin, N.M., Zaik, M., Bushby, K., Straub, V., Zatz, M., de Paula, F., Morgan, K., Fujiwara, T.M., Wrogemann, K. Hum. Mutat. (2005) [Pubmed]
  7. The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB. Albor, A., El-Hizawi, S., Horn, E.J., Laederich, M., Frosk, P., Wrogemann, K., Kulesz-Martin, M. J. Biol. Chem. (2006) [Pubmed]
  8. Brain 5-HT2A receptor occupancy of deramciclane in humans after a single oral administration--a positron emission tomography study. Kanerva, H., Vilkman, H., Någren, K., Kilkku, O., Kuoppamäki, M., Syvälahti, E., Hietala, J. Psychopharmacology (Berl.) (1999) [Pubmed]
  9. A positron emission tomography study of the effects of treatment with valproate on brain 5-HT2A receptors in acute mania. Yatham, L.N., Liddle, P.F., Lam, R.W., Adam, M.J., Solomons, K., Chinnapalli, M., Ruth, T.J. Bipolar disorders. (2005) [Pubmed]
  10. Hutterite brothers both affected with two forms of limb girdle muscular dystrophy: LGMD2H and LGMD2I. Frosk, P., Del Bigio, M.R., Wrogemann, K., Greenberg, C.R. Eur. J. Hum. Genet. (2005) [Pubmed]
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