Disease relevance of PPRC1

• We conclude that overexpression of the PRC pathway is responsible for mitochondrial proliferation in the context of thyroid oncocytoma [1].

Psychiatry related information on PPRC1

High impact information on PPRC1

• These findings suggest that formation of a transformation-specific PRC complex may have a major role in resetting patterns of gene expression by regulating chromatin structure [2].
• The results establish that PRC is an immediate early gene product that can target key transcription factors as an early event in the program of cellular proliferation [3].
• Finally, PRC associates with the cytochrome c promoter in vivo and its occupancy of the promoter is markedly elevated in response to serum induction of quiescent fibroblasts [3].
• PRC is ubiquitously expressed in murine and human tissues and cell lines; but unlike PGC-1, PRC was not dramatically up-regulated during thermogenesis in brown fat [4].

Chemical compound and disease context of PPRC1

Biological context of PPRC1

• PRC also contains a potent transcriptional activation domain in its amino terminus adjacent to an LXXLL motif [4].
• Here, we establish that PRC belongs to the class of immediate early genes that are rapidly induced in the transition from quiescence to proliferative growth [3].
• Surprisingly, we find that the PRC complexes can be localized to discrete binding sites or spread through large regions of the mouse and human genomes [5].

Anatomical context of PPRC1

• However, unlike PGC-1, PRC is not induced significantly during thermogenesis but rather is cell-cycle regulated in cultured cells under conditions where PGC-1 is not expressed [6].

Associations of PPRC1 with chemical compounds

Other interactions of PPRC1

• In particular, environmental signals induce the expression of PGC-1 family coactivators (PGC-1alpha, PGC-1beta, and PRC), which in turn target specific transcription factors (NRF-1, NRF-2, and ERR alpha) in the expression of respiratory genes [7].
• A second, more recently defined class, includes nuclear coactivators typified by PGC-1 and related family members (PRC and PGC-1 beta) [8].

Analytical, diagnostic and therapeutic context of PPRC1

• Moreover, NRF-1 was immunoprecipitated from cell extracts by antibodies directed against PRC, and both proteins were colocalized to the nucleoplasm by confocal laser scanning microscopy [4].

References